Abi1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAbi1 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Abi1(Gene name) > Rat

Abi1 (Gene name),

Abl interactor 1 (Protein name ), ABI1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Abi1;

Protein name:

Abl interactor 1;

Alternative:

Eps8 SH3 domain-binding protein(Eps8-binding protein);Abelson interactor 1(Abi-1);e3B1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with ABL1, ENAH, STX1A, SNAP25, VAMP2, EPS8, SOS1, SOS2, GRB2, SPTA1, NCKAP1/NAP1, the first SH3 domain of NCK1 and through its N-terminus with WASF1. Part of a complex consisting of ABI1, STX1A and SNAP25. Part of a complex consisting of ABI1, EPS8 and SOS1. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2.

Function:

May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level.

Subcellular Location:

Cytoplasm Nucleus Cell projection lamellipodium Cell projection filopodium Cell projection growth cone Cell junction synapse synaptosome Cytoplasm cytoskeleton Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes.

Protein Attributes:

Sequence length:

476

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

476:

WFEGVCNRVT | GLFPGNYVES | IMHYTD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9QZM5

UniGene:

Rn.43675

Pfam:

PF07815

String:

Q9QZM5

Uniprot:

Q9QZM5

FOR

ELISA Kit for Rat Abl interactor 1

CLIA Kit for Rat Abl interactor 1

Polyclonal Antibody for Rat Abl interactor 1

Monoclonal Antibody for Rat Abl interactor 1

Protein for Rat Abl interactor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"cDNA sequence of the rat eps8 binding protein (e3B1)."
Nicolas G. , Galand C. , Lecomte M.C.
Submitted (1999-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
2.

"Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system."
Courtney K.D. , Grove M. , Vandongen H. , Vandongen A. , LaMantia A.-S. , Pendergast A.M.
Mol. Cell. Neurosci.16:244-257(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
3.

"Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation."
Proepper C. , Johannsen S. , Liebau S. , Dahl J. , Vaida B. , Bockmann J. , Kreutz M.R. , Gundelfinger E.D. , Boeckers T.M.
EMBO J.26:1397-1409(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEUROGENESIS;INTERACTION WITH EPS8; MYC; MAX; SHANK2; SHANK3 AND WASF1;PHOSPHORYLATION AT TYR-53;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;MUTAGENESIS OF TYR-53

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