Abl interactor 2 (Protein name
), ABI2_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
ABI2(ARGBPIA);
Protein name:
Abl interactor 2;
Alternative:
Abl-binding protein 3(AblBP3);Abelson interactor 2(Abi-2);Arg-binding protein 1(ArgBP1);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Interacts with ABL1 and ABL2.
Function:
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.
Subcellular Location:
Isoform 1
Cell projection
lamellipodium
Cell projection
filopodium
Cytoplasm
cytoskeleton
Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3);FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION;INTERACTION WITH ABL1
2.
"Cloning of a binding substrate of the Abl protein tyrosine kinase." Ren R.
Submitted (1995-07) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH ABL2
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227 AND SER-368;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS) OF 1-164;SUBUNIT
Vaild Sequence:
