Gene name:
ACCN1 (ACCN;BNAC1;MDEG) ;
Protein name:
Amiloride-sensitive cation channel 1, neuronal ;
Alternative:
Amiloride-sensitive brain sodium channel ;Acid-sensing ion channel 2 (ASIC2) ;Brain sodium channel 1 (BNC1;BNaC1) ;Amiloride-sensitive cation channel neuronal 1 ;Mammalian degenerin homolog ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM (By similarity). Interacts with PRKCABP and ACCN3.
Function:
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes.
Protein Attributes:
50:
MDLKESPSEG | SLQPSSIQIF | ANTSTLHGIR | HIFVYGPLTI | RRVLWAVAFV |
100:
GSLGLLLVES | SERVSYYFSY | QHVTKVDEVV | AQSLVFPAVT | LCNLNGFRFS |
150:
RLTTNDLYHA | GELLALLDVN | LQIPDPHLAD | PSVLEALRQK | ANFKHYKPKQ |
200:
FSMLEFLHRV | GHDLKDMMLY | CKFKGQECGH | QDFTTVFTKY | GKCYMFNSGE |
250:
DGKPLLTTVK | GGTGNGLEIM | LDIQQDEYLP | IWGETEETTF | EAGVKVQIHS |
300:
QSEPPFIQEL | GFGVAPGFQT | FVATQEQRLT | YLPPPWGECR | SSEMGLDFFP |
350:
VYSITACRID | CETRYIVENC | NCRMVHMPGD | APFCTPEQHK | ECAEPALGLL |
400:
AEKDSNYCLC | RTPCNLTRYN | KELSMVKIPS | KTSAKYLEKK | FNKSEKYISE |
450:
NILVLDIFFE | ALNYETIEQK | KAYEVAALLG | DIGGQMGLFI | GASILTILEL |
500:
FDYIYELIKE | KLLDLLGKEE | DEGSHDENVS | TCDTMPNHSE | TISHTVNVPL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Human Amiloride-sensitive cation channel 1, neuronal
ELISA Kit for Human Amiloride-sensitive cation channel 1, neuronal
ELISA Kit for Human Amiloride-sensitive cation channel 1, neuronal
CLIA Kit for Human Amiloride-sensitive cation channel 1, neuronal
CLIA Kit for Human Amiloride-sensitive cation channel 1, neuronal
CLIA Kit for Human Amiloride-sensitive cation channel 1, neuronal
Polyclonal Antibody for Human Amiloride-sensitive cation channel 1, neuronal
Polyclonal Antibody for Human Amiloride-sensitive cation channel 1, neuronal
Polyclonal Antibody for Human Amiloride-sensitive cation channel 1, neuronal
Monoclonal Antibody for Human Amiloride-sensitive cation channel 1, neuronal
Monoclonal Antibody for Human Amiloride-sensitive cation channel 1, neuronal
Monoclonal Antibody for Human Amiloride-sensitive cation channel 1, neuronal
Protein for Human Amiloride-sensitive cation channel 1, neuronal
Protein for Human Amiloride-sensitive cation channel 1, neuronal
Protein for Human Amiloride-sensitive cation channel 1, neuronal
R&D Technical Data
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Precision
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Recovery
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Linearity
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