Accn2 ELISA Kit for Mouse(Mus musculus) | EIAab.comAccn2 ELISA Kit for Mouse(Mus musculus)

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Accn2 (Gene name),

Amiloride-sensitive cation channel 2, neuronal (Protein name ), ACCN2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Accn2(Asic;Asic1;Bnac2);

Protein name:

Amiloride-sensitive cation channel 2, neuronal;

Alternative:

Acid-sensing ion channel 1;Acid-sensing ion channel;Brain sodium channel 2(BNaC2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with PRKCABP and ACCN1 (By similarity). Interacts with STOM.

Function:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

Subcellular Location:

Cell membrane Multi-pass membrane protein Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4.

Protein Attributes:

Sequence length:

526

Sequence:

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