ACCN3 ELISA Kit for Human(Homo sapiens) | EIAab.comACCN3 ELISA Kit for Human(Homo sapiens)

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ACCN3 (Gene name),

Amiloride-sensitive cation channel 3 (Protein name ), ACCN3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

ACCN3(ASIC3;SLNAC1;TNAC1);

Protein name:

Amiloride-sensitive cation channel 3;

Alternative:

Neuronal amiloride-sensitive cation channel 3;Acid-sensing ion channel 3(ASIC3;hASIC3);Testis sodium channel 1(hTNaC1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM and DLG4 (By similarity). Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ACCN1.

Function:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cytoplasm Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells.

Protein Attributes:

Sequence length:

531

Sequence:

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