Accn3 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAccn3 ELISA Kit for Rat(Rattus norvegicus)

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Accn3 (Gene name),

Amiloride-sensitive cation channel 3 (Protein name ), ACCN3_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Accn3(Asic3;Drasic);

Protein name:

Amiloride-sensitive cation channel 3;

Alternative:

Dorsal root ASIC(DRASIC);Acid-sensing ion channel 3(ASIC3);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with STOM, LIN7B, MAGI1 and GOPC (By similarity). Interacts with DLG4 and ACCN1.

Function:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Subcellular Location:

Cytoplasm Cell membrane Multi-pass membrane protein In part cytoplasmic in cochlea cells (By similarity). Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4.

Protein Attributes:

Sequence length:

533

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