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Index > Protein center > ACD(Gene name) > Human
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  • ACD (Gene name),
  • Adrenocortical dysplasia protein homolog (Protein name ),  ACD_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ACD(PIP1;PTOP;TINT1;TPP1);
    Protein name:
    Adrenocortical dysplasia protein homolog;
    Alternative:
    POT1 and TIN2-interacting protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1/OBFC1 and TINF2.
    Function:
    Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.
    Subcellular Location:
    Nucleus Chromosome telomere
    Protein Attributes:
    Sequence length:
    544
    Sequence:
    50:
    MPGRCQSDAA | MRVNGPASRA | PAGWTSGSLH | TGPRAGRPRA | QARGVRGRGL | 
    100:
    LLRPRPAKEL | PLPRKGGAWA | PAGNPGPLHP | LGVAVGMAGS | GRLVLRPWIR | 
    150:
    ELILGSETPS | SPRAGQLLEV | LQDAEAAVAG | PSHAPDTSDV | GATLLVSDGT | 
    200:
    HSVRCLVTRE | ALDTSDWEEK | EFGFRGTEGR | LLLLQDCGVH | VQVAEGGAPA | 
    250:
    EFYLQVDRFS | LLPTEQPRLR | VPGCNQDLDV | QKKLYDCLEE | HLSESTSSNA | 
    300:
    GLSLSQLLDE | MREDQEHQGA | LVCLAESCLT | LEGPCTAPPV | THWAASRCKA | 
    350:
    TGEAVYTVPS | SMLCISENDQ | LILSSLGPCQ | RTQGPELPPP | DPALQDLSLT | 
    400:
    LIASPPSSPS | SSGTPALPGH | MSSEESGTSI | SLLPALSLAA | PDPGQRSSSQ | 
    450:
    PSPAICSAPA | TLTPRSPHAS | RTPSSPLQSC | TPSLSPRSHV | PSPHQALVTR | 
    500:
    PQKPSLEFKE | FVGLPCKNRP | PFPRTGATRG | AQEPCSVWEP | PKRHRDGSAF | 
    544:
    QYEYEPPCTS | LCARVQAVRL | PPQLMAWALH | FLMDAQPGSE | PTPM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    UniGene:
    MIM:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Adrenocortical dysplasia protein homolog
    ELISA Kit for Human Adrenocortical dysplasia protein homolog
    ELISA Kit for Human Adrenocortical dysplasia protein homolog
    CLIA Kit for Human Adrenocortical dysplasia protein homolog
    CLIA Kit for Human Adrenocortical dysplasia protein homolog
    CLIA Kit for Human Adrenocortical dysplasia protein homolog
    Polyclonal Antibody for Human Adrenocortical dysplasia protein homolog
    Polyclonal Antibody for Human Adrenocortical dysplasia protein homolog
    Polyclonal Antibody for Human Adrenocortical dysplasia protein homolog
    Monoclonal Antibody for Human Adrenocortical dysplasia protein homolog
    Monoclonal Antibody for Human Adrenocortical dysplasia protein homolog
    Monoclonal Antibody for Human Adrenocortical dysplasia protein homolog
    Protein for Human Adrenocortical dysplasia protein homolog
    Protein for Human Adrenocortical dysplasia protein homolog
    Protein for Human Adrenocortical dysplasia protein homolog

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Placenta.
    2. 2.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-518
      tissue: Duodenum.
    4. 4.
      "Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator."
      Keegan C.E. , Hutz J.E. , Else T. , Adamska M. , Shah S.P. , Kent A.E. , Howes J.M. , Beamer W.G. , Hammer G.D.
      Hum. Mol. Genet.14:113-123(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 65-544;ALTERNATIVE SPLICING (ISOFORM 1)
    5. 5.
      "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex."
      Ye J.Z.-S. , Hockemeyer D. , Krutchinsky A.N. , Loayza D. , Hooper S.M. , Chait B.T. , de Lange T.
      Genes Dev.18:1649-1654(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH POT1 AND TINF2;IDENTIFICATION BY MASS SPECTROMETRY
    6. 6.
      "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres."
      Ye J.Z.-S. , Donigian J.R. , van Overbeek M. , Loayza D. , Luo Y. , Krutchinsky A.N. , Chait B.T. , de Lange T.
      J. Biol. Chem.279:47264-47271(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE SHELTERIN COMPLEX
    7. 7.
      "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins."
      Liu D. , O'Connor M.S. , Qin J. , Songyang Z.
      J. Biol. Chem.279:51338-51342(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE SHELTERIN COMPLEX
    8. 8.
      "Shelterin: the protein complex that shapes and safeguards human telomeres."
      de Lange T.
      Genes Dev.19:2100-2110(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE SHELTERIN COMPLEX
    9. 9.
      "A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly."
      O'Connor M.S. , Safari A. , Xin H. , Liu D. , Songyang Z.
      Proc. Natl. Acad. Sci. U.S.A.103:11874-11879(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SHELTERIN COMPLEX ASSEMBLY
    10. 10.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation."
      Wan M. , Qin J. , Songyang Z. , Liu D.
      J. Biol. Chem.284:26725-26731(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH OBFC1
    14. 14.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    15. 15.
      "Functional interaction between telomere protein TPP1 and telomerase."
      Zaug A.J. , Podell E.R. , Nandakumar J. , Cech T.R.
      Genes Dev.24:613-622(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 16.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      "PTOP interacts with POT1 and regulates its localization to telomeres."
      Liu D. , Safari A. , O'Connor M.S. , Chan D.W. , Laegeler A. , Qin J. , Songyang Z.
      Nat. Cell Biol.6:673-680(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MOTIF;SUBCELLULAR LOCATION;INTERACTION WITH POT1 AND TINF2;FUNCTION;VARIANT ALA-518
    18. 18.
      "The POT1-TPP1 telomere complex is a telomerase processivity factor."
      Wang F. , Podell E.R. , Zaug A.J. , Yang Y. , Baciu P. , Cech T.R. , Lei M.
      Nature445:506-510(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 90-250;FUNCTION;SUBUNIT;IDENTIFICATION IN A COMPLEX WITH POT1 AND SINGLE-STRANDED TELOMERIC DNA
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