Gene name:
ACD (PIP1;PTOP;TINT1;TPP1) ;
Protein name:
Adrenocortical dysplasia protein homolog ;
Alternative:
POT1 and TIN2-interacting protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1/OBFC1 and TINF2.
Function:
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.
Subcellular Location:
Nucleus
Chromosome
telomere
Protein Attributes:
50:
MPGRCQSDAA | MRVNGPASRA | PAGWTSGSLH | TGPRAGRPRA | QARGVRGRGL |
100:
LLRPRPAKEL | PLPRKGGAWA | PAGNPGPLHP | LGVAVGMAGS | GRLVLRPWIR |
150:
ELILGSETPS | SPRAGQLLEV | LQDAEAAVAG | PSHAPDTSDV | GATLLVSDGT |
200:
HSVRCLVTRE | ALDTSDWEEK | EFGFRGTEGR | LLLLQDCGVH | VQVAEGGAPA |
250:
EFYLQVDRFS | LLPTEQPRLR | VPGCNQDLDV | QKKLYDCLEE | HLSESTSSNA |
300:
GLSLSQLLDE | MREDQEHQGA | LVCLAESCLT | LEGPCTAPPV | THWAASRCKA |
350:
TGEAVYTVPS | SMLCISENDQ | LILSSLGPCQ | RTQGPELPPP | DPALQDLSLT |
400:
LIASPPSSPS | SSGTPALPGH | MSSEESGTSI | SLLPALSLAA | PDPGQRSSSQ |
450:
PSPAICSAPA | TLTPRSPHAS | RTPSSPLQSC | TPSLSPRSHV | PSPHQALVTR |
500:
PQKPSLEFKE | FVGLPCKNRP | PFPRTGATRG | AQEPCSVWEP | PKRHRDGSAF |
544:
QYEYEPPCTS | LCARVQAVRL | PPQLMAWALH | FLMDAQPGSE | PTPM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Adrenocortical dysplasia protein homolog
ELISA Kit for Human Adrenocortical dysplasia protein homolog
ELISA Kit for Human Adrenocortical dysplasia protein homolog
CLIA Kit for Human Adrenocortical dysplasia protein homolog
CLIA Kit for Human Adrenocortical dysplasia protein homolog
CLIA Kit for Human Adrenocortical dysplasia protein homolog
Polyclonal Antibody for Human Adrenocortical dysplasia protein homolog
Polyclonal Antibody for Human Adrenocortical dysplasia protein homolog
Polyclonal Antibody for Human Adrenocortical dysplasia protein homolog
Monoclonal Antibody for Human Adrenocortical dysplasia protein homolog
Monoclonal Antibody for Human Adrenocortical dysplasia protein homolog
Monoclonal Antibody for Human Adrenocortical dysplasia protein homolog
Protein for Human Adrenocortical dysplasia protein homolog
Protein for Human Adrenocortical dysplasia protein homolog
Protein for Human Adrenocortical dysplasia protein homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Placenta .
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-518
tissue :
Duodenum .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 65-544;ALTERNATIVE SPLICING (ISOFORM 1)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH POT1 AND TINF2;IDENTIFICATION BY MASS SPECTROMETRY
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE SHELTERIN COMPLEX
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE SHELTERIN COMPLEX
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH OBFC1
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MOTIF;SUBCELLULAR LOCATION;INTERACTION WITH POT1 AND TINF2;FUNCTION;VARIANT ALA-518
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 90-250;FUNCTION;SUBUNIT;IDENTIFICATION IN A COMPLEX WITH POT1 AND SINGLE-STRANDED TELOMERIC DNA