ACER2 ELISA Kit for Human(Homo sapiens) | EIAab.comACER2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ACER2(Gene name) > Human

ACER2 (Gene name),

Alkaline ceramidase 2 (Protein name ), ACER2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ACER2(PP11646;ASAH3L);

Protein name:

Alkaline ceramidase 2(AlkCDase 2;Alkaline CDase 2;haCER2);

Alternative:

N-acylsphingosine amidohydrolase 3-like;Acylsphingosine deacylase 3-like;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.

Subcellular Location:

Golgi apparatus membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

275

Sequence:

50:

100:

150:

200:

250:

275:

EKWAFIGVPY | VSLLCANKKS | SVKIT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

613492

String:

Q5QJU3

Pfam:

PF05875

UniGene:

Hs.41379

KEGG:

hsa:340485

STRING:

9606.ENSP00000342609

Uniprot:

Q5QJU3

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ELISA Kit for Human AlkCDase 2

Cat.:

E11204h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human AlkCDase 2

Cat.:

E11204m

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MSDS:

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Packing:

96T

CLIA Kit for Human AlkCDase 2

Cat.:

U11204m

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MSDS:

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Packing:

96T

CLIA Kit for Human AlkCDase 2

Cat.:

U11204h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human AlkCDase 2

Cat.:

P11204Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human AlkCDase 2

Cat.:

P11204Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human AlkCDase 2

Protein for Human AlkCDase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P."
Xu R. , Jin J. , Hu W. , Sun W. , Bielawski J. , Szulc Z. , Taha T. , Obeid L.M. , Mao C.
FASEB J.20:1813-1825(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
2.

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
3.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Placenta.
5.

"Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion."
Sun W. , Hu W. , Xu R. , Jin J. , Szulc Z.M. , Zhang G. , Galadari S.H. , Obeid L.M. , Mao C.
FASEB J.23:656-666(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2)."
Sun W. , Jin J. , Xu R. , Hu W. , Szulc Z.M. , Bielawski J. , Obeid L.M. , Mao C.
J. Biol. Chem.285:8995-9007(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;SUBCELLULAR LOCATION;TOPOLOGY

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