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Index > Protein center > CHRNA7(Gene name) > Human
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  • CHRNA7 (Gene name),
  • Neuronal acetylcholine receptor subunit alpha-7 (Protein name ),  ACHA7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CHRNA7(NACHRA7);
    Protein name:
    Neuronal acetylcholine receptor subunit alpha-7;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.
    Function:
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
    Subcellular Location:
    Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    502
    Sequence:
    50:
    MRCSPGGVWL | ALAASLLHVS | LQGEFQRKLY | KELVKNYNPL | ERPVANDSQP | 
    100:
    LTVYFSLSLL | QIMDVDEKNQ | VLTTNIWLQM | SWTDHYLQWN | VSEYPGVKTV | 
    150:
    RFPDGQIWKP | DILLYNSADE | RFDATFHTNV | LVNSSGHCQY | LPPGIFKSSC | 
    200:
    YIDVRWFPFD | VQHCKLKFGS | WSYGGWSLDL | QMQEADISGY | IPNGEWDLVG | 
    250:
    IPGKRSERFY | ECCKEPYPDV | TFTVTMRRRT | LYYGLNLLIP | CVLISALALL | 
    300:
    VFLLPADSGE | KISLGITVLL | SLTVFMLLVA | EIMPATSDSV | PLIAQYFAST | 
    350:
    MIIVGLSVVV | TVIVLQYHHH | DPDGGKMPKW | TRVILLNWCA | WFLRMKRPGE | 
    400:
    DKVRPACQHK | QRRCSLASVE | MSAVAPPPAS | NGNLLYIGFR | GLDGVHCVPT | 
    450:
    PDSGVVCGRM | ACSPTHDEHL | LHGGQPPEGD | PDLAKILEEV | RYIANRFRCQ | 
    500:
    DESEAVCSEW | KFAACVVDRL | CLMAFSVFTI | ICTIGILMSA | PNFVEAVSKD | 
    502:
    FA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    MIM:
    SMR:
    UniGene:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
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    ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-7
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    CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-7
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    CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-7
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    Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-7
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    Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-7
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    Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-7
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    Packing:
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    Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-7
    Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-7
    Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-7
    Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-7
    Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-7
    Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-7
    Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-7
    Protein for Human Neuronal acetylcholine receptor subunit alpha-7
    Protein for Human Neuronal acetylcholine receptor subunit alpha-7
    Protein for Human Neuronal acetylcholine receptor subunit alpha-7
    Protein for Human Neuronal acetylcholine receptor subunit alpha-7
    Protein for Human Neuronal acetylcholine receptor subunit alpha-7

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    Precision
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    Linearity
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    References
    1. 1.
      "Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes."
      Peng X. , Katz M. , Gerzanich V. , Anand R. , Lindstrom J.
      Mol. Pharmacol.45:546-554(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Nucleotide sequence and transcript size of the alpha-7 neuronal nicotinic acetylcholine receptor in human postmortem brain."
      Logel J. , Drebing C. , Barnhart M. , Antle C. , Leonard S.
      Submitted (1995-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Hippocampus.
    3. 3.
      "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
      Elliott K.J. , Ellis S.B. , Berckhan K.J. , Urrutia A. , Chavez-Noriega L.E. , Johnson E.C. , Velicelebi G. , Harpold M.M.
      J. Mol. Neurosci.7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
      Groot Kormelink P.J. , Luyten W.H.M.L.
      FEBS Lett.400:309-314(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      Groot Kormelink P.J. , Luyten W.H.M.L.
      Submitted (1998-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    6. 6.
      "Cloning cholinergic receptors in human keratinocytes."
      Arredondo J. , Grando S.A.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Keratinocyte.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Amygdala.
      tissue: Stomach.
    8. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
    9. 10.
      "Cloning and sequence of the human alpha-7 nicotinic acetylcholine receptor."
      Doucette-Stamm L. , Monteggia L.M. , Donnelly-Roberts D. , Wang M.T. , Lee J. , Tian J. , Giordano T.
      Drug Dev. Res.30:252-256(1993)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-502 (ISOFORM 1)
      tissue: Brain.
    10. 11.
      "Molecular cloning and chromosomal localization of the human alpha 7-nicotinic receptor subunit gene (CHRNA7)."
      Chini B. , Raimondi E. , Elgoyhen A.B. , Moralli D. , Balzaretti M. , Heinemann S.F.
      Genomics19:379-381(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-502 (ISOFORM 1)
      tissue: Retina.
    11. 12.
      "A 3-Mb map of a large segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14."
      Riley B. , Williamson M. , Collier D. , Wilkie H. , Makoff A.
      Genomics79:197-209(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 118-129
    12. 13.
      "Cluster analysis of an extensive human breast cancer cell line protein expression map database."
      Harris R.A. , Yang A. , Stein R.C. , Lucy K. , Brusten L. , Herath A. , Parekh R. , Waterfield M.D. , O'Hare M.J. , Neville M.A. , Page M.J. , Zvelebil M.J.
      Proteomics2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MASS SPECTROMETRY
      tissue: Mammary cancer.
    13. 14.
      "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells."
      Williams M.E. , Burton B. , Urrutia A. , Shcherbatko A. , Chavez-Noriega L.E. , Cohen C.J. , Aiyar J.
      J. Biol. Chem.280:1257-1263(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIC3
    14. 15.
      "RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
      Lansdell S.J. , Gee V.J. , Harkness P.C. , Doward A.I. , Baker E.R. , Gibb A.J. , Millar N.S.
      Mol. Pharmacol.68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIC3
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