CHRNA9 ELISA Kit for Human(Homo sapiens) | EIAab.comCHRNA9 ELISA Kit for Human(Homo sapiens) | EIAab.com

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CHRNA9 (Gene name),

Neuronal acetylcholine receptor subunit alpha-9 (Protein name ), ACHA9_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

CHRNA9(NACHRA9);

Protein name:

Neuronal acetylcholine receptor subunit alpha-9;

Alternative:

Nicotinic acetylcholine receptor subunit alpha-9(NACHR alpha-9);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.

Function:

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.

Subcellular Location:

Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

479

Sequence:

50:

MNWSHSCISF | CWIYFAASRL | RAAETADGKY | AQKLFNDLFE | DYSNALRPVE |

100:

DTDKVLNVTL | QITLSQIKDM | DERNQILTAY | LWIRQIWHDA | YLTWDRDQYD |

150:

GLDSIRIPSD | LVWRPDIVLY | NKADDESSEP | VNTNVVLRYD | GLITWDAPAI |

200:

TKSSCVVDVT | YFPFDNQQCN | LTFGSWTYNG | NQVDIFNALD | SGDLSDFIED |

250:

VEWEVHGMPA | VKNVISYGCC | SEPYPDVTFT | LLLKRRSSFY | IVNLLIPCVL |

300:

ISFLAPLSFY | LPAASGEKVS | LGVTILLAMT | VFQLMVAEIM | PASENVPLIG |

350:

KYYIATMALI | TASTALTIMV | MNIHFCGAEA | RPVPHWARVV | ILKYMSRVLF |

400:

VYDVGESCLS | PHHSRERDHL | TKVYSKLPES | NLKAARNKDL | SRKKDMNKRL |

450:

KNDLGCQGKN | PQEAESYCAQ | YKVLTRNIEY | IAKCLKDHKA | TNSKGSEWKK |

479:

VAKVIDRFFM | WIFFIMVFVM | TILIIARAD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

SMR:

UniGene:

Pfam:

String:

STRING:

9606.ENSP00000312663

MIM:

Uniprot:

FOR

ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-9

ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-9

ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-9

CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-9

CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-9

CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-9

Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-9

Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-9

Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-9

Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-9

Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-9

Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-9

Protein for Human Neuronal acetylcholine receptor subunit alpha-9

Protein for Human Neuronal acetylcholine receptor subunit alpha-9

Protein for Human Neuronal acetylcholine receptor subunit alpha-9

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit."
Sgard F. , Charpantier E. , Bertrand S. , Walker N. , Caput D. , Graham D. , Bertrand D. , Besnard F.
Mol. Pharmacol.61:150-159(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH CHRNA10;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANT SER-442
tissue: Embryo.
2.

"Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene."
Lustig L.R. , Peng H.
Cytogenet. Genome Res.98:154-159(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-442
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT SER-442
5.

"Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity."
Nguyen V.T. , Ndoye A. , Grando S.A.
Am. J. Pathol.157:1377-1391(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-476;FUNCTION;TISSUE SPECIFICITY
6.

"Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes."
Peng H. , Ferris R.L. , Matthews T. , Hiel H. , Lopez-Albaitero A. , Lustig L.R.
Life Sci.76:263-280(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
7.

"Crystal structures of free and antagonist-bound states of human alpha9 nicotinic receptor extracellular domain."
Zouridakis M. , Giastas P. , Zarkadas E. , Chroni-Tzartou D. , Bregestovski P. , Tzartos S.J.
Nat. Struct. Mol. Biol.0:0-0(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.71 ANGSTROMS) OF 26-237;FUNCTION;SUBCELLULAR LOCATION;DISULFIDE BOND;GLYCOSYLATION

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