Chrna9 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comChrna9 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Chrna9(Gene name) > Rat

Chrna9 (Gene name),

Neuronal acetylcholine receptor subunit alpha-9 (Protein name ), ACHA9_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Chrna9(Acra9);

Protein name:

Neuronal acetylcholine receptor subunit alpha-9;

Alternative:

Nicotinic acetylcholine receptor subunit alpha-9(NACHR alpha-9);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.

Function:

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.

Subcellular Location:

Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

479

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

479:

VAKVIDRFFM | WIFFAMVFVM | TVLIIARAD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10116.ENSRNOP00000003382

KEGG:

rno:65024

Pfam:

PF02931

String:

P43144

UniGene:

Rn.54463

Uniprot:

P43144

FOR

ELISA Kit for Rat Neuronal acetylcholine receptor subunit alpha-9

CLIA Kit for Rat Neuronal acetylcholine receptor subunit alpha-9

Polyclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-9

Monoclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-9

Protein for Rat Neuronal acetylcholine receptor subunit alpha-9

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Alpha 9: an acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells."
Elgoyhen A.B. , Johnson D.S. , Boulter J. , Vetter D.E. , Heinemann S.F.
Cell79:705-715(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Olfactory epithelium.
2.

Groot-Kormelink P.J.
Submitted (2004-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Brain.
3.

"High calcium permeability and calcium block of the alpha9 nicotinic acetylcholine receptor."
Katz E. , Verbitsky M. , Rothlin C.V. , Vetter D.E. , Heinemann S.F. , Elgoyhen A.B.
Hear. Res.141:117-128(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
4.

"Mixed nicotinic-muscarinic properties of the alpha9 nicotinic cholinergic receptor."
Verbitsky M. , Rothlin C.V. , Katz E. , Elgoyhen A.B.
Neuropharmacology39:2515-2524(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells."
Elgoyhen A.B. , Vetter D.E. , Katz E. , Rothlin C.V. , Heinemann S.F. , Boulter J.
Proc. Natl. Acad. Sci. U.S.A.98:3501-3506(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CHRNA10;SUBUNIT;TISSUE SPECIFICITY;FUNCTION;SUBCELLULAR LOCATION
6.

"The alpha9alpha10 nicotinic acetylcholine receptor is permeable to and is modulated by divalent cations."
Weisstaub N. , Vetter D.E. , Elgoyhen A.B. , Katz E.
Hear. Res.167:122-135(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CHRNA10
7.

"Coexpression of alpha 9 and alpha 10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons."
Lips K.S. , Pfeil U. , Kummer W.
Neuroscience115:1-5(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
8.

"Pharmacological properties of alpha 9 alpha 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras."
Baker E.R. , Zwart R. , Sher E. , Millar N.S.
Mol. Pharmacol.65:453-460(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CHRNA10

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