CHRNA1 ELISA Kit for Human(Homo sapiens) | EIAab.comCHRNA1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CHRNA1(Gene name) > Human

CHRNA1 (Gene name),

Acetylcholine receptor subunit alpha (Protein name ), ACHA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CHRNA1(ACHRA;CHNRA);

Protein name:

Acetylcholine receptor subunit alpha;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Location:

Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

482

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

482:

MDHILLGVFM | LVCIIGTLAV | FAGRLIELNQ | QG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000261007

UniGene:

Hs.434479

SMR:

P02708

MIM:

100690

Pfam:

PF02931

KEGG:

hsa:1134

String:

P02708

Uniprot:

P02708

FOR

ELISA Kit for Human Acetylcholine receptor subunit alpha

CLIA Kit for Human Acetylcholine receptor subunit alpha

Polyclonal Antibody for Human Acetylcholine receptor subunit alpha

Monoclonal Antibody for Human Acetylcholine receptor subunit alpha

Protein for Human Acetylcholine receptor subunit alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor."
Noda M. , Furutani Y. , Takahashi H. , Toyosato M. , Tanabe T. , Shimizu S. , Kikyotani S. , Kayano T. , Hirose T. , Inayama S. , Numa S.
Nature305:818-823(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"The human medulloblastoma cell line TE671 expresses a muscle-like acetylcholine receptor. Cloning of the alpha-subunit cDNA."
Schoepfer R. , Luther M. , Lindstrom J.M.
FEBS Lett.226:235-240(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"The human muscle nicotinic acetylcholine receptor alpha-subunit exist as two isoforms: a novel exon."
Beeson D. , Morris A. , Vincent A. , Newsom-Davis J.
EMBO J.9:2101-2106(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 2)
tissue: Muscle.
4.

"Cloning of a cDNA coding for the acetylcholine receptor alpha-subunit from a thymoma associated with myasthenia gravis."
Gattenloehner S. , Brabletz T. , Schultz A. , Marx A. , Mueller-Hermelink H.-K. , Kirchner T.
Thymus23:103-113(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Thymus.
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Tongue.
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"Amphipathic segment of the nicotinic receptor alpha subunit contains epitopes recognized by T lymphocytes in myasthenia gravis."
Hohlfeld R. , Toyka K.V. , Miner L.L. , Walgrave S.L. , Conti-Tronconi B.M.
J. Clin. Invest.81:657-660(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-482 (ISOFORM 1)
8.

"Differential expression of human nicotinic acetylcholine receptor alpha subunit variants in muscle and non-muscle tissues."
Talib S. , Okarma T.B. , Lebkowski J.S.
Nucleic Acids Res.21:233-237(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 78-113
9.

"Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity."
Sine S.M. , Ohno K. , Bouzat C. , Auerbach A. , Milone M. , Pruitt J.N. II , Engel A.G.
Neuron15:229-239(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SCCMS SER-198
10.

"New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome."
Engel A.G. , Ohno K. , Milone M. , Wang H.-L. , Nakano S. , Bouzat C. , Pruitt J.N. II , Hutchinson D.O. , Brengman J.M. , Bren N. , Sieb J.P. , Sine S.M.
Hum. Mol. Genet.5:1217-1227(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SCCMS LYS-262
11.

"Mutations in different functional domains of the human muscle acetylcholine receptor alpha subunit in patients with the slow-channel congenital myasthenic syndrome."
Croxen R. , Newland C. , Beeson D. , Oosterhuis H. , Chauplannaz G. , Vincent A. , Newsom-Davis J.
Hum. Mol. Genet.6:767-774(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SCCMS SER-198; MET-201; ILE-299 AND ILE-314
12.

"Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit."
Milone M. , Wang H.-L. , Ohno K. , Fukudome T. , Pruitt J.N. II , Bren N. , Sine S.M. , Engel A.G.
J. Neurosci.17:5651-5665(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SCCMS PHE-294;CHARACTERIZATION OF VARIANT SCCMS PHE-294
13.

"Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating."
Wang H.-L. , Milone M. , Ohno K. , Shen X.-M. , Tsujino A. , Batocchi A.-P. , Tonali P. , Brengman J. , Engel A.G. , Sine S.M.
Nat. Neurosci.2:226-233(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FCCMS VAL-278 AND ILE-330;CHARACTERIZATION OF VARIANTS FCCMS VAL-278 AND ILE-330
14.

Wang H.-L. , Milone M. , Ohno K. , Shen X.-M. , Tsujino A. , Batocchi A.-P. , Tonali P. , Brengman J. , Engel A.G. , Sine S.M.
Nat. Neurosci.2:485-485(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
15.

"Mutation causing severe myasthenia reveals functional asymmetry of AChR signature cystine loops in agonist binding and gating."
Shen X.-M. , Ohno K. , Tsujino A. , Brengman J.M. , Gingold M. , Sine S.M. , Engel A.G.
J. Clin. Invest.111:497-505(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FCCMS LEU-177;CHARACTERIZATION OF VARIANT FCCMS LEU-177
16.

"Mutation in the AChR ion channel gate underlies a fast channel congenital myasthenic syndrome."
Webster R. , Brydson M. , Croxen R. , Newsom-Davis J. , Vincent A. , Beeson D.
Neurology62:1090-1096(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FCCMS LEU-301;CHARACTERIZATION OF VARIANT FCCMS LEU-301
17.

"Slow-channel mutation in acetylcholine receptor alphaM4 domain and its efficient knockdown."
Shen X.-M. , Deymeer F. , Sine S.M. , Engel A.G.
Ann. Neurol.60:128-136(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SCCMS TRP-463;CHARACTERIZATION OF VARIANT SCCMS TRP-463
18.

"Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders."
Michalk A. , Stricker S. , Becker J. , Rupps R. , Pantzar T. , Miertus J. , Botta G. , Naretto V.G. , Janetzki C. , Yaqoob N. , Ott C.-E. , Seelow D. , Wieczorek D. , Fiebig B. , Wirth B. , Hoopmann M. , Walther M. , Koerber F. , more...
Am. J. Hum. Genet.82:464-476(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LMPS LEU-254

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