CHRNB2 ELISA Kit for Human(Homo sapiens) | EIAab.comCHRNB2 ELISA Kit for Human(Homo sapiens)

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CHRNB2 (Gene name),

Neuronal acetylcholine receptor subunit beta-2 (Protein name ), ACHB2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CHRNB2;

Protein name:

Neuronal acetylcholine receptor subunit beta-2;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Location:

Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

502

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

502:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.2306

KEGG:

hsa:1141

Pfam:

PF02931

STRING:

9606.ENSP00000357461

SMR:

P17787

MIM:

118507

String:

P17787

Uniprot:

P17787

FOR

ELISA Kit for Human Neuronal acetylcholine receptor subunit beta-2

CLIA Kit for Human Neuronal acetylcholine receptor subunit beta-2

Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit beta-2

Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit beta-2

Protein for Human Neuronal acetylcholine receptor subunit beta-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Nucleotide sequence of the human nicotinic acetylcholine receptor beta 2 subunit gene."
Anand R. , Lindstrom J.
Nucleic Acids Res.18:4272-4272(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Fetal brain.
2.

"Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
Elliott K.J. , Ellis S.B. , Berckhan K.J. , Urrutia A. , Chavez-Noriega L.E. , Johnson E.C. , Velicelebi G. , Harpold M.M.
J. Mol. Neurosci.7:217-228(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
3.

"Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
Groot Kormelink P.J. , Luyten W.H.M.L.
FEBS Lett.400:309-314(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Frontal cortex.
4.

"The structures of the human neuronal nicotinic acetylcholine receptor beta2- and alpha3-subunit genes (CHRNB2 and CHRNA3)."
Rempel N. , Heyers S. , Engels H. , Sleegers E. , Steinlein O.K.
Hum. Genet.103:645-653(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Genomic organization and mapping of the human and mouse neuronal beta2-nicotinic acetylcholine receptor genes."
Lueders K.K. , Elliott R.W. , Marenholz I. , Mischke D. , DuPree M. , Hamer D.
Mamm. Genome10:900-905(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
7.

"RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
Lansdell S.J. , Gee V.J. , Harkness P.C. , Doward A.I. , Baker E.R. , Gibb A.J. , Millar N.S.
Mol. Pharmacol.68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIC3
8.

"NMR structure of the transmembrane domain of the n-acetylcholine receptor beta2 subunit."
Bondarenko V. , Tillman T. , Xu Y. , Tang P.
Biochim. Biophys. Acta1798:1608-1614(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 231-486
9.

"NMR structures of the transmembrane domains of the alpha4beta2 nAChR."
Bondarenko V. , Mowrey D. , Tillman T. , Cui T. , Liu L.T. , Xu Y. , Tang P.
Biochim. Biophys. Acta1818:1261-1268(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 234-484;SUBUNIT;FUNCTION
10.

"The nicotinic receptor beta-2 subunit is mutant in nocturnal frontal lobe epilepsy."
De Fusco M. , Becchetti A. , Patrignani A. , Annesi G. , Gambardella A. , Quattrone A. , Ballabio A. , Wanke E. , Casari G.
Nat. Genet.26:275-276(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ENFL3 LEU-287
11.

"CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy."
Phillips H.A. , Favre I. , Kirkpatrick M. , Zuberi S.M. , Goudie D. , Heron S.E. , Scheffer I.E. , Sutherland G.R. , Berkovic S.F. , Bertrand D. , Mulley J.C.
Am. J. Hum. Genet.68:225-231(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ENFL3 MET-287
12.

"Genetic and functional analysis of single nucleotide polymorphisms in the beta2-neuronal nicotinic acetylcholine receptor gene (CHRNB2)."
Lueders K.K. , Hu S. , McHugh L. , Myakishev M.V. , Sirota L.A. , Hamer D.H.
Nicotine Tob. Res.4:115-125(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-397

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