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Index > Protein center > Acin1(Gene name) > Mouse
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  • Acin1 (Gene name),
  • Apoptotic chromatin condensation inducer in the nucleus (Protein name ),  ACINU_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Acin1(Acinus);
    Protein name:
    Apoptotic chromatin condensation inducer in the nucleus(Acinus);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Found in a mRNA splicing-dependent exon junction complex (EJC), at least composed of ACIN1, CASC3, EIF4A3, MAGOH, PNN, RBM8A, RNPS1, SAP18 and THOC4. Forms heterodimers with RNPS1. Found in a heterotrimeric complex with ACIN1, RNPS1 and SAP18. Interacts with API5.
    Function:
    Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1338
    Sequence:
    50:
    MWGRKRPNSS | GETRGILSGN | RGVDYGSGRG | QSGPFEGRWR | KLPKMPEAVG | 
    100:
    TDPSTSRKMA | ELEEVTLDGK | PLQALRVTDL | KAALEQRGLA | KSGQKSALVK | 
    150:
    RLKGALMLEN | LQKHSTPHAA | FQPNSQIGEE | MSQNSFIKQY | LEKQQELLRQ | 
    200:
    RLEREAREAA | ELEEASAESE | DEMTHPEGVA | SLLPPDFQSS | LNRPELELST | 
    250:
    HSPRKSSSFS | EEKGESDDEK | PRKGERRSSR | VRQAKSKLPE | YSQTAEEEED | 
    300:
    QETPSRNLRV | RADRNLKIEE | EEEEEEEEED | DDDEEEEEVD | EAQKSREAEA | 
    350:
    PTLKQFEDEE | GEERTRAKPE | KVVDEKPLNI | RSQEKGELEK | GGRVTRSQEE | 
    400:
    ARRSHLARQQ | QEKETQIVSL | PQEENEVKSS | QSLEEKSQSP | SPPPLPEDLE | 
    450:
    KAPVVLQPEQ | IVSEEETPPP | LLTKEASSPP | THIQLQEEME | PVEGPAPPVL | 
    500:
    IQLSPPNTDA | GAREPLASPH | PAQLLRSLSP | LSGTTDTKAE | SPAGRVSDES | 
    550:
    VLPLAQKSSL | PECSTQKGVE | SEREKSAPLP | LTVEEFAPAK | GITEEPMKKQ | 
    600:
    SLEQKEGRRA | SHALFPEHSG | KQSADSSSSR | SSSPSSSSSP | SRSPSPDSVA | 
    650:
    SRPQSSPGSK | QRDGAQARVH | ANPHERPKMG | SRSTSESRSR | SRSRSRSASS | 
    700:
    SSRKSLSPGV | SRDSNTSYTE | TKDPSCGQEA | AAPSGPQLQV | LEPKEKAPTF | 
    750:
    SASVRGRHLS | HPEPEQQHVI | QRLQPEQGSP | KKCEAEEAEP | PAATQPQTSE | 
    800:
    TQISHLLESE | RTHHTVEEKE | EVTMDTSENR | PENEVPEPPL | PVADQVSNDE | 
    850:
    RPEGGAEEEE | KKESSMPKSF | KRKISVVSAT | KGVQAGNSDT | EGGQPGRKRR | 
    900:
    WGASTAATQK | KPSISITTES | LKSLIPDIKP | LAGQEAVVDL | HADDSRISED | 
    950:
    ETERNGDDGT | HDKGLKICRT | VTQVVPAEGQ | ENGQREEEEE | KEPEAELPAP | 
    1000:
    PQVSVEVALP | PPVEHEVKKV | TLGDTLTRRS | ISQQKSGVSI | TIDDPVRTAQ | 
    1050:
    VPSPPRGKIS | NIVHISNLVR | PFTLGQLKEL | LGRTGTLVEE | AFWIDKIKSH | 
    1100:
    CFVTYSTVEE | AVATRTALHG | VKWPQSNPKF | LCADYAEQDE | LDYHRGLLVD | 
    1150:
    RPSETKAEEQ | GAPRPLHPPP | PPPVQPPPHP | RAEQREQERA | VREQWAERER | 
    1200:
    EMERRERTRS | EREWDRDKVR | EGPRSRSRSR | DRRRKERAKS | KEKKSEKKEK | 
    1250:
    AQEEPPAKLL | DDLFRKTKAA | PCIYWLPLTE | SQIVQKEAEQ | AERAKEREKR | 
    1300:
    RKEREEEEQK | EREKEAERER | NRQLEREKRR | EHSRERERDR | ERERDRGDRE | 
    1338:
    RERERDRDRG | RERDRRDTKR | HSRSRSRSTP | VRDRGGRR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    UniGene:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Acinus
    ELISA Kit for Mouse Acinus
    CLIA Kit for Mouse Acinus
    CLIA Kit for Mouse Acinus
    Polyclonal Antibody for Mouse Acinus
    Polyclonal Antibody for Mouse Acinus
    Monoclonal Antibody for Mouse Acinus
    Monoclonal Antibody for Mouse Acinus
    Protein for Mouse Acinus
    Protein for Mouse Acinus

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation."
      Sahara S. , Aoto M. , Eguchi Y. , Imamoto N. , Yoneda Y. , Tsujimoto Y.
      Nature401:168-173(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3)
    2. 2.
      "Molecular cloning of murine acinusL, a gene for apoptotic chromatin condensation."
      Mamoru A. , Setsuko S. , Yoshihide T.
      Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-284 (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1190 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-806 (ISOFORM 4)
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Pancreatic islet.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295; SER-391; SER-479; SER-491 AND SER-710;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    6. 6.
      "Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1."
      Jang S.W. , Yang S.J. , Ehlen A. , Dong S. , Khoury H. , Chen J. , Persson J.L. , Ye K.
      Cancer Res.68:4559-4570(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRPK2
    7. 7.
      "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
      J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1003;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    8. 8.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216 AND SER-710;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479; SER-491 AND SER-1003;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    10. 10.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-861;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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