TNK2 ELISA Kit for Bovine(Bos taurus) | EIAab.comTNK2 ELISA Kit for Bovine(Bos taurus)

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Index > Protein center > TNK2(Gene name) > Bovine

TNK2 (Gene name),

Activated CDC42 kinase 1 (Protein name ), ACK1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TNK2(ACK1;ACK2);

Protein name:

Activated CDC42 kinase 1(ACK-1);

Alternative:

Tyrosine kinase non-receptor protein 2;Activated CDC42 kinase 2;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with CDC42. Interacts with activated CSPG4 (By similarity). Interacts with AR. Interacts with NPHP1 (By similarity). Interacts with SNX9 (via SH3 domain). Interacts with SRC (via SH2 and SH3 domain). Interacts with EGFR and this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts (via kinase domain) with AKT1. Interacts with NEDD4 (via WW3 domain) and NEDD4L and EGF promotes its association with NEDD4.

Function:

Non-receptor tyrosine kinase that regulates the activity of a number of proteins by tyrosine phosphorylation especially proteins critical for cell survival, cell growth, and proliferation. Activates AKT1 by phosphorylating it on 'Tyr-176' resulting in its activation. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' and promotes its recruitment to the androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.

Subcellular Location:

Cell membrane Nucleus Endosome Cell junction adherens junction Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side The Tyr-284 phosphorylated form is expressed both in the membrane and nucleus. Co-localizes with EGFR on the endosomes.

Protein Attributes:

Sequence length:

1039

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1039:

GLGLRPRGEC | HNVLEMFDWN | LEQAGCHLLG | SCGPAHHKR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF09027

String:

Q17R13

UniGene:

Bt.64988

SMR:

Q17R13

KEGG:

bta:280710

Uniprot:

Q17R13

FOR

ELISA Kit for Bovine ACK-1

CLIA Kit for Bovine ACK-1

Polyclonal Antibody for Bovine ACK-1

Monoclonal Antibody for Bovine ACK-1

Protein for Bovine ACK-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and characterization of a novel Cdc42-associated tyrosine kinase, ACK-2, from bovine brain."
Yang W. , Cerione R.A.
J. Biol. Chem.272:24819-24824(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);CATALYTIC ACTIVITY;INTERACTION WITH CDC42
tissue: Brain.
2.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2006-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: Hereford.
tissue: Hypothalamus.
3.

"The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation."
Lin Q. , Lo C.G. , Cerione R.A. , Yang W.
J. Biol. Chem.277:10134-10138(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SNX9 AND EGFR;IDENTIFICATION IN A COMPLEX WITH SNX9 AND CLATHRIN HEAVY CHAIN;MUTAGENESIS OF LYS-158

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