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Index > Protein center > Tnk2(Gene name) > Mouse
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  • Tnk2 (Gene name),
  • Activated CDC42 kinase 1 (Protein name ),  ACK1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Tnk2(Ack1);
    Protein name:
    Activated CDC42 kinase 1(ACK-1);
    Alternative:
    Tyrosine kinase non-receptor protein 2;Non-receptor protein tyrosine kinase Ack;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer (By similarity). Interacts with CDC42. Interacts with activated CSPG4 (By similarity). Interacts with SNX9 (via SH3 domain). Interacts with AR (By similarity). Interacts with WWOX (By similarity). Interacts with MERTK (activated); stimulates autophosphorylation (By similarity). May interact (phosphorylated) with HSP90AB1; maintains kinase activity. Interacts with NPHP1 (By similarity). Interacts with SRC (via SH2 and SH3 domain) (By similarity). Interacts with EGFR and this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts (via kinase domain) with AKT1. Interacts with NEDD4 (via WW3 domain) and NEDD4L and EGF promotes its association with NEDD4.
    Function:
    Non-receptor tyrosine kinase that regulates the activity of a number of proteins by tyrosine phosphorylation especially proteins critical for cell survival, cell growth, and proliferation. Activates AKT1 by phosphorylating it on 'Tyr-176' resulting in its activation. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' and promotes its recruitment to the androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.
    Subcellular Location:
    Cell membrane Nucleus Endosome Cell junction adherens junction Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side The Tyr-284 phosphorylated form is expressed both in the membrane and nucleus. Co-localizes with EGFR on the endosomes.
    Protein Attributes:
    Sequence length:
    1055
    Sequence:
    50:
    MQPEEGTGWL | LELLSEVQLQ | QYFLRLRDDL | NITRLSHFEY | VKNEDLEKIG | 
    100:
    MGRPGQRRLW | EAVKRRKAMC | KRKSWMSKVF | SGKRLEAEFP | SQHSQSTFRK | 
    150:
    PSPTPGSLPG | EGTLQSLTCL | IGEKDLRLLE | KLGDGSFGVV | RRGEWDAPAG | 
    200:
    KTVSVAVKCL | KPDVLSQPEA | MDDFIREVNA | MHSLDHRNLI | RLYGVVLTLP | 
    250:
    MKMVTELAPL | GSLLDRLRKH | QGHFLLGTLS | RYAVQVAEGM | AYLESKRFIH | 
    300:
    RDLAARNLLL | ATRDLVKIGD | FGLMRALPQN | DDHYVMQEHR | KVPFAWCAPE | 
    350:
    SLKTRTFSHA | SDTWMFGVTL | WEMFTYGQEP | WIGLNGSQIL | HKIDKEGERL | 
    400:
    PRPEDCPQDI | YNVMVQCWAH | KPEDRPTFVA | LRDFLLEAQP | TDMRALQDFE | 
    450:
    EPDKLHIQMN | DVITVIEGRA | ENYWWRGQNT | RTLCVGPFPR | NVVTSVAGLS | 
    500:
    AQDISQPLQN | SFIHTGHGDS | DPRHCWGFPD | RIDELYLGNP | MDPPDLLSVE | 
    550:
    LSTSRPTQHL | GRVKREPPPR | PPQPAIFTQK | TTYDPVSEDP | DPLSSDFKRL | 
    600:
    GLRKPALPRG | LWLAKPSARV | PGTKADRSSG | GEVTLIDFGE | EPVVPTPRPC | 
    650:
    APSLAQLAMD | ACSLLDKTPP | QSPTRALPRP | LHPTPVVDWD | ARPLPPPPAY | 
    700:
    DDVAQDEDDF | EVCSINSTLV | GAGLPAGPSQ | GETNYAFVPE | QAQMPPALED | 
    750:
    NLFLPPQGGG | KPPSSVQTAE | IFQALQQECM | RQLQVPTGQL | TPSPTPGGDD | 
    800:
    KPQVPPRVPI | PPRPTRPRVE | LSPAPSGEEE | TSRWPGPASP | PRVPPREPLS | 
    850:
    PQGSRTPSPL | VPPGSSPLPH | RLSSSPGKTM | PTTQSFASDP | KYATPQVIQA | 
    900:
    PGPRAGPCIL | PIVRDGRKVS | STHYYLLPER | PPYLERYQRF | LREAQSPEEP | 
    950:
    AALPVPPLLP | PPSTPAPAAP | TATVRPMPQA | APDPKANFST | NNSNPGARPP | 
    1000:
    SLRAAARLPQ | RGCPGDGQEA | ARPADKVQML | QAMVHGVTTE | ECQAALQSHS | 
    1050:
    WSVQRAAQYL | KVEQLFGLGL | RPRVECHKVL | EMFDWNLEQA | GCHLLGSCGP | 
    1055:
    AHHKR
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse ACK-1
    ELISA Kit for Mouse ACK-1
    ELISA Kit for Mouse ACK-1
    ELISA Kit for Mouse ACK-1
    CLIA Kit for Mouse ACK-1
    CLIA Kit for Mouse ACK-1
    CLIA Kit for Mouse ACK-1
    CLIA Kit for Mouse ACK-1
    Polyclonal Antibody for Mouse ACK-1
    Polyclonal Antibody for Mouse ACK-1
    Polyclonal Antibody for Mouse ACK-1
    Polyclonal Antibody for Mouse ACK-1
    Monoclonal Antibody for Mouse ACK-1
    Monoclonal Antibody for Mouse ACK-1
    Monoclonal Antibody for Mouse ACK-1
    Monoclonal Antibody for Mouse ACK-1
    Protein for Mouse ACK-1
    Protein for Mouse ACK-1
    Protein for Mouse ACK-1
    Protein for Mouse ACK-1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Activation of the nonreceptor protein tyrosine kinase Ack by multiple extracellular stimuli."
      Galisteo M.L. , Yang Y. , Urena J. , Schlessinger J.
      Proc. Natl. Acad. Sci. U.S.A.103:9796-9801(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-158; TRP-424 AND HIS-464
    2. 2.
      "The protein tyrosine kinase Ack is associated with and activated in vivo by CDC42Hs."
      Her J.-H. , Bolen J.B.
      Submitted (1997-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      strain: C57BL/6.
      tissue: Brain.
      tissue: Colon.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 121-1055 (ISOFORM 3)
      strain: NOD.
      tissue: Thymus.
    5. 5.
      "Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain."
      Urena J.M. , La Torre A. , Martinez A. , Lowenstein E. , Franco N. , Winsky-Sommerer R. , Fontana X. , Casaroli-Marano R. , Ibanez-Sabio M.A. , Pascual M. , Del Rio J.A. , de Lecea L. , Soriano E.
      J. Comp. Neurol.490:119-132(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDC42;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    6. 6.
      "Expression pattern of ACK1 tyrosine kinase during brain development in the mouse."
      La Torre A. , del Rio J.A. , Soriano E. , Urena J.M.
      Gene Expr. Patterns6:886-892(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    7. 7.
      "Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation."
      Shen F. , Lin Q. , Gu Y. , Childress C. , Yang W.
      Mol. Biol. Cell18:732-742(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EGFR;SUBCELLULAR LOCATION;DOMAIN EBD AND UBA;MUTAGENESIS OF TYR-650
    8. 8.
      "Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct."
      Eley L. , Moochhala S.H. , Simms R. , Hildebrandt F. , Sayer J.A.
      Biochem. Biophys. Res. Commun.371:877-882(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-518 (ISOFORMS 2 AND 3);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    10. 10.
      "HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK."
      Lin Q. , Wang J. , Childress C. , Sudol M. , Carey D.J. , Yang W.
      Mol. Cell. Biol.30:1541-1554(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEDD4 AND NEDD4L;UBIQUITINATION;INDUCTION;DOMAIN SAM-LIKE AND UBA
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AKT1;SUBCELLULAR LOCATION
    12. 12.
      "Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin."
      Shen H. , Ferguson S.M. , Dephoure N. , Park R. , Yang Y. , Volpicelli-Daley L. , Gygi S. , Schlessinger J. , De Camilli P.
      Mol. Biol. Cell22:493-502(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT TYR-284 AND TYR-533
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