Protein name:
Activated CDC42 kinase 1 (ACK-1) ;
Alternative:
Tyrosine kinase non-receptor protein 2 ;Non-receptor protein tyrosine kinase Ack ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer (By similarity). Interacts with CDC42. Interacts with activated CSPG4 (By similarity). Interacts with SNX9 (via SH3 domain). Interacts with AR (By similarity). Interacts with WWOX (By similarity). Interacts with MERTK (activated); stimulates autophosphorylation (By similarity). May interact (phosphorylated) with HSP90AB1; maintains kinase activity. Interacts with NPHP1 (By similarity). Interacts with SRC (via SH2 and SH3 domain) (By similarity). Interacts with EGFR and this interaction is dependent on EGF stimulation and kinase activity of EGFR. Interacts (via kinase domain) with AKT1. Interacts with NEDD4 (via WW3 domain) and NEDD4L and EGF promotes its association with NEDD4.
Function:
Non-receptor tyrosine kinase that regulates the activity of a number of proteins by tyrosine phosphorylation especially proteins critical for cell survival, cell growth, and proliferation. Activates AKT1 by phosphorylating it on 'Tyr-176' resulting in its activation. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' and promotes its recruitment to the androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development.
Subcellular Location:
Cell membrane
Nucleus
Endosome
Cell junction
adherens junction
Cytoplasmic vesicle membrane
Peripheral membrane protein
Cytoplasmic side
The Tyr-284 phosphorylated form is expressed both in the membrane and nucleus. Co-localizes with EGFR on the endosomes.
Protein Attributes:
50:
MQPEEGTGWL | LELLSEVQLQ | QYFLRLRDDL | NITRLSHFEY | VKNEDLEKIG |
100:
MGRPGQRRLW | EAVKRRKAMC | KRKSWMSKVF | SGKRLEAEFP | SQHSQSTFRK |
150:
PSPTPGSLPG | EGTLQSLTCL | IGEKDLRLLE | KLGDGSFGVV | RRGEWDAPAG |
200:
KTVSVAVKCL | KPDVLSQPEA | MDDFIREVNA | MHSLDHRNLI | RLYGVVLTLP |
250:
MKMVTELAPL | GSLLDRLRKH | QGHFLLGTLS | RYAVQVAEGM | AYLESKRFIH |
300:
RDLAARNLLL | ATRDLVKIGD | FGLMRALPQN | DDHYVMQEHR | KVPFAWCAPE |
350:
SLKTRTFSHA | SDTWMFGVTL | WEMFTYGQEP | WIGLNGSQIL | HKIDKEGERL |
400:
PRPEDCPQDI | YNVMVQCWAH | KPEDRPTFVA | LRDFLLEAQP | TDMRALQDFE |
450:
EPDKLHIQMN | DVITVIEGRA | ENYWWRGQNT | RTLCVGPFPR | NVVTSVAGLS |
500:
AQDISQPLQN | SFIHTGHGDS | DPRHCWGFPD | RIDELYLGNP | MDPPDLLSVE |
550:
LSTSRPTQHL | GRVKREPPPR | PPQPAIFTQK | TTYDPVSEDP | DPLSSDFKRL |
600:
GLRKPALPRG | LWLAKPSARV | PGTKADRSSG | GEVTLIDFGE | EPVVPTPRPC |
650:
APSLAQLAMD | ACSLLDKTPP | QSPTRALPRP | LHPTPVVDWD | ARPLPPPPAY |
700:
DDVAQDEDDF | EVCSINSTLV | GAGLPAGPSQ | GETNYAFVPE | QAQMPPALED |
750:
NLFLPPQGGG | KPPSSVQTAE | IFQALQQECM | RQLQVPTGQL | TPSPTPGGDD |
800:
KPQVPPRVPI | PPRPTRPRVE | LSPAPSGEEE | TSRWPGPASP | PRVPPREPLS |
850:
PQGSRTPSPL | VPPGSSPLPH | RLSSSPGKTM | PTTQSFASDP | KYATPQVIQA |
900:
PGPRAGPCIL | PIVRDGRKVS | STHYYLLPER | PPYLERYQRF | LREAQSPEEP |
950:
AALPVPPLLP | PPSTPAPAAP | TATVRPMPQA | APDPKANFST | NNSNPGARPP |
1000:
SLRAAARLPQ | RGCPGDGQEA | ARPADKVQML | QAMVHGVTTE | ECQAALQSHS |
1050:
WSVQRAAQYL | KVEQLFGLGL | RPRVECHKVL | EMFDWNLEQA | GCHLLGSCGP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
ELISA Kit for Mouse ACK-1
ELISA Kit for Mouse ACK-1
ELISA Kit for Mouse ACK-1
ELISA Kit for Mouse ACK-1
Polyclonal Antibody for Mouse ACK-1
Polyclonal Antibody for Mouse ACK-1
Polyclonal Antibody for Mouse ACK-1
Polyclonal Antibody for Mouse ACK-1
Monoclonal Antibody for Mouse ACK-1
Monoclonal Antibody for Mouse ACK-1
Monoclonal Antibody for Mouse ACK-1
Monoclonal Antibody for Mouse ACK-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-158; TRP-424 AND HIS-464
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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more...
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 121-1055 (ISOFORM 3)
strain :
NOD .
tissue :
Thymus .
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[
Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CDC42;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-518 (ISOFORMS 2 AND 3);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NEDD4 AND NEDD4L;UBIQUITINATION;INDUCTION;DOMAIN SAM-LIKE AND UBA
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PLoS ONE5:E9646-E9646(2010)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH AKT1;SUBCELLULAR LOCATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;PHOSPHORYLATION AT TYR-284 AND TYR-533