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Index > Protein center > DARC(Gene name) > Human
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  • DARC (Gene name),
  • Duffy antigen/chemokine receptor (Protein name ),  ACKR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    DARC(ACKR1;FY;GPD);
    Protein name:
    Duffy antigen/chemokine receptor;
    Alternative:
    Fy glycoprotein(GpFy);Atypical chemokine receptor 1;Plasmodium vivax receptor;Glycoprotein D;
    CD:
    CD234;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
    Subcellular Location:
    Early endosome Recycling endosome Membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
    Protein Attributes:
    Sequence length:
    336
    Sequence:
    50:
    MGNCLHRAEL | SPSTENSSQL | DFEDVWNSSY | GVNDSFPDGD | YGANLEAAAP | 
    100:
    CHSCNLLDDS | ALPFFILTSV | LGILASSTVL | FMLFRPLFRW | QLCPGWPVLA | 
    150:
    QLAVGSALFS | IVVPVLAPGL | GSTRSSALCS | LGYCVWYGSA | FAQALLLGCH | 
    200:
    ASLGHRLGAG | QVPGLTLGLT | VGIWGVAALL | TLPVTLASGA | SGGLCTLIYS | 
    250:
    TELKALQATH | TVACLAIFVL | LPLGLFGAKG | LKKALGMGPG | PWMNILWAWF | 
    300:
    IFWWPHGVVL | GLDFLVRSKL | LLLSTCLAQQ | ALDLLLNLAE | ALAILHCVAT | 
    336:
    PLLLALFCHQ | ATRTLLPSLP | LPEGWSSHLD | TLGSKS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Duffy antigen/chemokine receptor
    ELISA Kit for Human Duffy antigen/chemokine receptor
    ELISA Kit for Human Duffy antigen/chemokine receptor
    ELISA Kit for Human Duffy antigen/chemokine receptor
    ELISA Kit for Human Duffy antigen/chemokine receptor
    ELISA Kit for Human Duffy antigen/chemokine receptor
    CLIA Kit for Human Duffy antigen/chemokine receptor
    CLIA Kit for Human Duffy antigen/chemokine receptor
    CLIA Kit for Human Duffy antigen/chemokine receptor
    CLIA Kit for Human Duffy antigen/chemokine receptor
    CLIA Kit for Human Duffy antigen/chemokine receptor
    CLIA Kit for Human Duffy antigen/chemokine receptor
    Polyclonal Antibody for Human Duffy antigen/chemokine receptor
    Polyclonal Antibody for Human Duffy antigen/chemokine receptor
    Polyclonal Antibody for Human Duffy antigen/chemokine receptor
    Polyclonal Antibody for Human Duffy antigen/chemokine receptor
    Polyclonal Antibody for Human Duffy antigen/chemokine receptor
    Polyclonal Antibody for Human Duffy antigen/chemokine receptor
    Monoclonal Antibody for Human Duffy antigen/chemokine receptor
    Monoclonal Antibody for Human Duffy antigen/chemokine receptor
    Monoclonal Antibody for Human Duffy antigen/chemokine receptor
    Monoclonal Antibody for Human Duffy antigen/chemokine receptor
    Monoclonal Antibody for Human Duffy antigen/chemokine receptor
    Monoclonal Antibody for Human Duffy antigen/chemokine receptor
    Protein for Human Duffy antigen/chemokine receptor
    Protein for Human Duffy antigen/chemokine receptor
    Protein for Human Duffy antigen/chemokine receptor
    Protein for Human Duffy antigen/chemokine receptor
    Protein for Human Duffy antigen/chemokine receptor
    Protein for Human Duffy antigen/chemokine receptor

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    References
    1. 1.
      "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite."
      Chaudhuri A. , Polyakova J. , Zbrzezna V. , Williams K. , Gulati S. , Pogo A.
      Proc. Natl. Acad. Sci. U.S.A.90:10793-10797(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;VARIANT ASP-42
      tissue: Bone marrow.
    2. 2.
      "Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals."
      Tournamille C. , Colin Y. , Cartron J.-P. , Le van Kim C.
      Nat. Genet.10:224-228(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ASP-42
      tissue: Blood.
    3. 3.
      "Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue."
      Iwamoto S. , Omi T. , Kajii E. , Ikemoto S.
      Blood85:622-626(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Blood.
    4. 4.
      "Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals."
      Tournamille C. , Le Van Kim C. , Gane P. , Le Pennec P.Y. , Roubinet F. , Babinet J. , Cartron J.-P. , Colin Y.
      Blood92:2147-2156(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2);VARIANTS ASP-42; CYS-89 AND THR-100
      tissue: Blood.
    5. 5.
      "The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein."
      Olsson M.L. , Smythe J.S. , Hansson C. , Poole J. , Mallinson G. , Jones J. , Avent N.D. , Daniels G.
      Br. J. Haematol.103:1184-1191(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ASP-42; CYS-89 AND THR-100
    6. 6.
      "New polymorphisms in DARC."
      Doescher A.
      Submitted (2007-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PHE-326
      tissue: Peripheral blood.
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT PHE-326
      tissue: Lung.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-117 (ISOFORMS 1 AND 2)
    10. 10.
      "Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites."
      Tournamille C. , Filipe A. , Wasniowska K. , Gane P. , Lisowska E. , Cartron J.-P. , Colin Y. , Le Van Kim C.
      Br. J. Haematol.122:1014-1023(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS;GLYCOSYLATION AT ASN-16
    11. 11.
      "Reduced Plasmodium vivax erythrocyte infection in PNG Duffy-negative heterozygotes."
      Kasehagen L.J. , Mueller I. , Kiniboro B. , Bockarie M.J. , Reeder J.C. , Kazura J.W. , Kastens W. , McNamara D.T. , King C.H. , Whalen C.C. , Zimmerman P.A.
      PLoS ONE2:E336-E336(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN RESISTANCE TO MALARIA
    12. 12.
      "Chemokine decoy receptors: structure-function and biological properties."
      Bonecchi R. , Savino B. , Borroni E.M. , Mantovani A. , Locati M.
      Curr. Top. Microbiol. Immunol.341:15-36(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    13. 13.
      "Duffy antigen receptor for chemokines and its involvement in patterning and control of inflammatory chemokines."
      Novitzky-Basso I. , Rot A.
      Front. Immunol.3:266-266(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    14. 14.
      "The biochemistry and biology of the atypical chemokine receptors."
      Graham G.J. , Locati M. , Mantovani A. , Rot A. , Thelen M.
      Immunol. Lett.145:30-38(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    16. 16.
      "Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism."
      Tournamille C. , Le van Kim C. , Gane P. , Cartron J.-P. , Colin Y.
      Hum. Genet.95:407-410(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASP-42
      tissue: Peripheral blood.
    17. 17.
      "A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype."
      Parasol N. , Reid M. , Rios M. , Castilho L. , Harari I. , Kosower N.S.
      Blood92:2237-2243(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYS-89
    18. 18.
      "Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart Studies."
      Nalls M.A. , Wilson J.G. , Patterson N.J. , Tandon A. , Zmuda J.M. , Huntsman S. , Garcia M. , Hu D. , Li R. , Beamer B.A. , Patel K.V. , Akylbekova E.L. , Files J.C. , Hardy C.L. , Buxbaum S.G. , Taylor H.A. , Reich D. , Harris T.B. , more...
      Am. J. Hum. Genet.82:81-87(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN WBCQ1
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
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