Gene name:
DARC (ACKR1;FY;GPD) ;
Protein name:
Duffy antigen/chemokine receptor ;
Alternative:
Fy glycoprotein (GpFy) ;Atypical chemokine receptor 1 ;Plasmodium vivax receptor ;Glycoprotein D ;
CD:
CD234 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
Subcellular Location:
Early endosome
Recycling endosome
Membrane
Multi-pass membrane protein
Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
Protein Attributes:
50:
MGNCLHRAEL | SPSTENSSQL | DFEDVWNSSY | GVNDSFPDGD | YGANLEAAAP |
100:
CHSCNLLDDS | ALPFFILTSV | LGILASSTVL | FMLFRPLFRW | QLCPGWPVLA |
150:
QLAVGSALFS | IVVPVLAPGL | GSTRSSALCS | LGYCVWYGSA | FAQALLLGCH |
200:
ASLGHRLGAG | QVPGLTLGLT | VGIWGVAALL | TLPVTLASGA | SGGLCTLIYS |
250:
TELKALQATH | TVACLAIFVL | LPLGLFGAKG | LKKALGMGPG | PWMNILWAWF |
300:
IFWWPHGVVL | GLDFLVRSKL | LLLSTCLAQQ | ALDLLLNLAE | ALAILHCVAT |
336:
PLLLALFCHQ | ATRTLLPSLP | LPEGWSSHLD | TLGSKS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Bovine
Mouse
Bovine
Mouse
Human
ELISA Kit for Human Duffy antigen/chemokine receptor
ELISA Kit for Human Duffy antigen/chemokine receptor
ELISA Kit for Human Duffy antigen/chemokine receptor
ELISA Kit for Human Duffy antigen/chemokine receptor
ELISA Kit for Human Duffy antigen/chemokine receptor
ELISA Kit for Human Duffy antigen/chemokine receptor
CLIA Kit for Human Duffy antigen/chemokine receptor
CLIA Kit for Human Duffy antigen/chemokine receptor
CLIA Kit for Human Duffy antigen/chemokine receptor
CLIA Kit for Human Duffy antigen/chemokine receptor
CLIA Kit for Human Duffy antigen/chemokine receptor
CLIA Kit for Human Duffy antigen/chemokine receptor
Polyclonal Antibody for Human Duffy antigen/chemokine receptor
Polyclonal Antibody for Human Duffy antigen/chemokine receptor
Polyclonal Antibody for Human Duffy antigen/chemokine receptor
Polyclonal Antibody for Human Duffy antigen/chemokine receptor
Polyclonal Antibody for Human Duffy antigen/chemokine receptor
Polyclonal Antibody for Human Duffy antigen/chemokine receptor
Monoclonal Antibody for Human Duffy antigen/chemokine receptor
Monoclonal Antibody for Human Duffy antigen/chemokine receptor
Monoclonal Antibody for Human Duffy antigen/chemokine receptor
Monoclonal Antibody for Human Duffy antigen/chemokine receptor
Monoclonal Antibody for Human Duffy antigen/chemokine receptor
Monoclonal Antibody for Human Duffy antigen/chemokine receptor
Protein for Human Duffy antigen/chemokine receptor
Protein for Human Duffy antigen/chemokine receptor
Protein for Human Duffy antigen/chemokine receptor
Protein for Human Duffy antigen/chemokine receptor
Protein for Human Duffy antigen/chemokine receptor
Protein for Human Duffy antigen/chemokine receptor
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Am. J. Hum. Genet.82:532-532(2008)
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Cited for : ERRATUM