ACKR3 ELISA Kit for Dog(Canis familiaris) | EIAab.comACKR3 ELISA Kit for Dog(Canis familiaris)

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ACKR3 (Gene name),

Atypical chemokine receptor 3 (Protein name ), ACKR3_CANFA from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ACKR3(CMKOR1;CXCR7;RDC1);

Protein name:

Atypical chemokine receptor 3;

Alternative:

Chemokine orphan receptor 1;C-X-C chemokine receptor type 7(CXC-R7);G-protein coupled receptor RDC1(RDC-1);

Organism:

Dog (Canis familiarisCanis lupus familiaris).

General Annotation

Sub Unit:

Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity (By similarity). Interacts with ARRB1 and ARRB2.

Function:

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cytoplasm Perinuclear region Early endosome Recycling endosome Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin-dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.

Protein Attributes:

Sequence length:

362

Sequence:

50:

100:

150:

200:

250:

300:

350:

362:

ETEYSALEQN | AK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

cfa:403964

UniGene:

Cfa.3822

Pfam:

PF00001

STRING:

9615.ENSCAFP00000017975

Uniprot:

P11613

FOR

ELISA Kit for Dog Atypical chemokine receptor 3

CLIA Kit for Dog Atypical chemokine receptor 3

Polyclonal Antibody for Dog Atypical chemokine receptor 3

Monoclonal Antibody for Dog Atypical chemokine receptor 3

Protein for Dog Atypical chemokine receptor 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Selective amplification and cloning of four new members of the G protein-coupled receptor family."
Libert F. , Parmentier M. , Lefort A. , Dinsart C. , van Sande J. , Maenhaut C. , Simons M.-J. , Dumont J.E. , Vassart G.
Science244:569-572(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Thyroid.
2.

"Complete nucleotide sequence of a putative G protein coupled receptor: RDC1."
Libert F. , Parmentier M. , Lefort A. , Dumont J.E. , Vassart G.
Nucleic Acids Res.18:1917-1917(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Thyroid.
3.

"Characterization of the RDC1 gene which encodes the canine homolog of a proposed human VIP receptor. Expression does not correlate with an increase in VIP binding sites."
Cook J.S. , Wolsing D.H. , Lameh J. , Olson C.A. , Correa P.E. , Sadee W. , Blumnthal E.M. , Rosenbaum J.S.
FEBS Lett.300:149-152(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SHOWS THAT RDC1 IS NOT A VIP RECEPTOR

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