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Index > Protein center > Ackr3(Gene name) > Mouse
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  • Ackr3 (Gene name),
  • Atypical chemokine receptor 3 (Protein name ),  ACKR3_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Ackr3(Cmkor1;Cxcr7;Rdc1);
    Protein name:
    Atypical chemokine receptor 3;
    Alternative:
    Chemokine orphan receptor 1;C-X-C chemokine receptor type 7(CXC-R7);G-protein coupled receptor RDC1 homolog(RDC-1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity (By similarity).Interacts with ARRB1 and ARRB2.
    Function:
    Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Cytoplasm Perinuclear region Early endosome Recycling endosome Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin -dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
    Protein Attributes:
    Sequence length:
    362
    Sequence:
    50:
    MDVHLFDYAE | PGNYSDINWP | CNSSDCIVVD | TVQCPTMPNK | NVLLYTLSFI | 
    100:
    YIFIFVIGMI | ANSVVVWVNI | QAKTTGYDTH | CYILNLAIAD | LWVVITIPVW | 
    150:
    VVSLVQHNQW | PMGELTCKIT | HLIFSINLFG | SIFFLACMSV | DRYLSITYFT | 
    200:
    GTSSYKKKMV | RRVVCILVWL | LAFFVSLPDT | YYLKTVTSAS | NNETYCRSFY | 
    250:
    PEHSIKEWLI | GMELVSVILG | FAVPFTIIAI | FYFLLARAMS | ASGDQEKHSS | 
    300:
    RKIIFSYVVV | FLVCWLPYHF | VVLLDIFSIL | HYIPFTCQLE | NVLFTALHVT | 
    350:
    QCLSLVHCCV | NPVLYSFINR | NYRYELMKAF | IFKYSAKTGL | TKLIDASRVS | 
    362:
    ETEYSALEQN | TK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Atypical chemokine receptor 3
    ELISA Kit for Mouse Atypical chemokine receptor 3
    ELISA Kit for Mouse Atypical chemokine receptor 3
    ELISA Kit for Mouse Atypical chemokine receptor 3
    CLIA Kit for Mouse Atypical chemokine receptor 3
    CLIA Kit for Mouse Atypical chemokine receptor 3
    CLIA Kit for Mouse Atypical chemokine receptor 3
    CLIA Kit for Mouse Atypical chemokine receptor 3
    Polyclonal Antibody for Mouse Atypical chemokine receptor 3
    Polyclonal Antibody for Mouse Atypical chemokine receptor 3
    Polyclonal Antibody for Mouse Atypical chemokine receptor 3
    Polyclonal Antibody for Mouse Atypical chemokine receptor 3
    Monoclonal Antibody for Mouse Atypical chemokine receptor 3
    Monoclonal Antibody for Mouse Atypical chemokine receptor 3
    Monoclonal Antibody for Mouse Atypical chemokine receptor 3
    Monoclonal Antibody for Mouse Atypical chemokine receptor 3
    Protein for Mouse Atypical chemokine receptor 3
    Protein for Mouse Atypical chemokine receptor 3
    Protein for Mouse Atypical chemokine receptor 3
    Protein for Mouse Atypical chemokine receptor 3

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1."
      Heesen M. , Berman M.A. , Charest A. , Housman D. , Gerard C. , Dorf M.E.
      Immunogenetics47:364-370(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      strain: 129/SvJ.
      tissue: Peritoneal exudate.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Forelimb.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
    4. 4.
      "A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development."
      Burns J.M. , Summers B.C. , Wang Y. , Melikian A. , Berahovich R. , Miao Z. , Penfold M.E. , Sunshine M.J. , Littman D.R. , Kuo C.J. , Wei K. , McMaster B.E. , Wright K. , Howard M.C. , Schall T.J.
      J. Exp. Med.203:2201-2213(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    5. 5.
      "Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7."
      Sierro F. , Biben C. , Martinez-Munoz L. , Mellado M. , Ransohoff R.M. , Li M. , Woehl B. , Leung H. , Groom J. , Batten M. , Harvey R.P. , Martinez-A C. , Mackay C.R. , Mackay F.
      Proc. Natl. Acad. Sci. U.S.A.104:14759-14764(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    7. 7.
      "Expression and function of CXCR7 in the mouse forebrain."
      Tiveron M.C. , Boutin C. , Daou P. , Moepps B. , Cremer H.
      J. Neuroimmunol.224:72-79(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling."
      Yu S. , Crawford D. , Tsuchihashi T. , Behrens T.W. , Srivastava D.
      Dev. Dyn.240:384-393(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
    10. 10.
      "Cxcr7 controls neuronal migration by regulating chemokine responsiveness."
      Sanchez-Alcaniz J.A. , Haege S. , Mueller W. , Pla R. , Mackay F. , Schulz S. , Lopez-Bendito G. , Stumm R. , Marin O.
      Neuron69:77-90(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
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