ACKR4 ELISA Kit for Human(Homo sapiens) | EIAab.comACKR4 ELISA Kit for Human(Homo sapiens) | EIAab.com

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ACKR4 (Gene name),

Atypical chemokine receptor 4 (Protein name ), ACKR4_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

ACKR4(CCBP2;CCR11;CCRL1;VSHK1);

Protein name:

Atypical chemokine receptor 4;

Alternative:

CC chemokine receptor-like 1(CCRL1);C-C chemokine receptor type 11(C-C CKR-11);CCX CKR;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms heteromers with CXCR3. Interacts with ARRB1 and ARRB2.

Function:

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.

Subcellular Location:

Early endosome Recycling endosome Cell membrane Multi-pass membrane protein Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.

Protein Attributes:

Sequence length:

350

Sequence:

50:

MALEQNQSTD | YYYEENEMNG | TYDYSQYELI | CIKEDVREFA | KVFLPVFLTI |

100:

VFVIGLAGNS | MVVAIYAYYK | KQRTKTDVYI | LNLAVADLLL | LFTLPFWAVN |

150:

AVHGWVLGKI | MCKITSALYT | LNFVSGMQFL | ACISIDRYVA | VTKVPSQSGV |

200:

GKPCWIICFC | VWMAAILLSI | PQLVFYTVND | NARCIPIFPR | YLGTSMKALI |

250:

QMLEICIGFV | VPFLIMGVCY | FITARTLMKM | PNIKISRPLK | VLLTVVIVFI |

300:

VTQLPYNIVK | FCRAIDIIYS | LITSCNMSKR | MDIAIQVTES | IALFHSCLNP |

350:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

MIM:

Pfam:

KEGG:

SMR:

STRING:

9606.ENSP00000249887

Uniprot:

FOR

ELISA Kit for Human Atypical chemokine receptor 4

ELISA Kit for Human Atypical chemokine receptor 4

ELISA Kit for Human Atypical chemokine receptor 4

CLIA Kit for Human Atypical chemokine receptor 4

CLIA Kit for Human Atypical chemokine receptor 4

CLIA Kit for Human Atypical chemokine receptor 4

Polyclonal Antibody for Human Atypical chemokine receptor 4

Polyclonal Antibody for Human Atypical chemokine receptor 4

Polyclonal Antibody for Human Atypical chemokine receptor 4

Monoclonal Antibody for Human Atypical chemokine receptor 4

Monoclonal Antibody for Human Atypical chemokine receptor 4

Monoclonal Antibody for Human Atypical chemokine receptor 4

Protein for Human Atypical chemokine receptor 4

Protein for Human Atypical chemokine receptor 4

Protein for Human Atypical chemokine receptor 4

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart."
Khoja H. , Wang G. , Ng C.-T.L. , Tucker J. , Brown T. , Shyamala V.
Gene246:229-238(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
2.

"CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines."
Schweickart V.L. , Epp A. , Raport C.J. , Gray P.W.
J. Biol. Chem.275:9550-9556(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
3.

"Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK."
Gosling J. , Dairaghi D.J. , Wang Y. , Hanley M. , Talbot D. , Miao Z. , Schall T.J.
J. Immunol.164:2851-2856(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION IN CHEMOKINES BINDING
4.

"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A. , Aronstam R.S. , Sharma S.V.
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR."
Townson J.R. , Nibbs R.J.
Eur. J. Immunol.32:1230-1241(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
8.

"Chemokine decoy receptors: structure-function and biological properties."
Bonecchi R. , Savino B. , Borroni E.M. , Mantovani A. , Locati M.
Curr. Top. Microbiol. Immunol.341:15-36(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
9.

"The biochemistry and biology of the atypical chemokine receptors."
Graham G.J. , Locati M. , Mantovani A. , Rot A. , Thelen M.
Immunol. Lett.145:30-38(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
10.

"Atypical chemokine receptors: from silence to sound."
Cancellieri C. , Vacchini A. , Locati M. , Bonecchi R. , Borroni E.M.
Biochem. Soc. Trans.41:231-236(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
11.

"Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR."
Vinet J. , van Zwam M. , Dijkstra I.M. , Brouwer N. , van Weering H.R. , Watts A. , Meijer M. , Fokkens M.R. , Kannan V. , Verzijl D. , Vischer H.F. , Smit M.J. , Leurs R. , Biber K. , Boddeke H.W.
Br. J. Pharmacol.168:1375-1387(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
12.

"Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR."
Watts A.O. , Verkaar F. , van der Lee M.M. , Timmerman C.A. , Kuijer M. , van Offenbeek J. , van Lith L.H. , Smit M.J. , Leurs R. , Zaman G.J. , Vischer H.F.
J. Biol. Chem.288:7169-7181(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH ARRB1 AND ARRB2

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