Actl6b ELISA Kit for Mouse(Mus musculus) | EIAab.comActl6b ELISA Kit for Mouse(Mus musculus)

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Actl6b (Gene name),

Actin-like protein 6B (Protein name ), ACL6B_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Actl6b(Actl6;Arpna;Baf53b);

Protein name:

Actin-like protein 6B;

Alternative:

Actin-related protein Baf53b;53 kDa BRG1-associated factor B;BRG1-associated factor 53B(BAF53B);ArpN-alpha(ArpNa);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of the bBAF complex, which includes at least actin (ACTB), ARID1A/BAF250, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCC2/BAF170, SMARCD2/BAF60B and SMARCE1/BAF57. Note that the bBAF complex is polymorphic in regard to the ATPase, SMARCA2 and SMARCA4 occupying mutually exclusive positions. PBRM1 does not belong to bBAF complex. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.

Function:

Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

426

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

426:

GTFQQMWISK | QEYEEGGKQC | VERKCP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q99MR0

Pfam:

PF00022

UniGene:

Mm.31646

KEGG:

mmu:83766

String:

Q99MR0

Uniprot:

Q99MR0

FOR

ELISA Kit for Mouse Actin-like protein 6B

CLIA Kit for Mouse Actin-like protein 6B

Polyclonal Antibody for Mouse Actin-like protein 6B

Monoclonal Antibody for Mouse Actin-like protein 6B

Protein for Mouse Actin-like protein 6B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex."
Kuroda Y. , Oma Y. , Nishimori K. , Ohta T. , Harata M.
Biochem. Biophys. Res. Commun.299:328-334(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH SMARCA2;INDUCTION
tissue: Embryonic carcinoma.
2.

"Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
Wilson M.D. , Riemer C. , Martindale D.W. , Schnupf P. , Boright A.P. , Cheung T.L. , Hardy D.M. , Schwartz S. , Scherer S.W. , Tsui L.-C. , Miller W. , Koop B.F.
Nucleic Acids Res.29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: 129/Sv.
3.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
5.

"Identification of a polymorphic, neuron-specific chromatin remodeling complex."
Olave I. , Wang W. , Xue Y. , Kuo A. , Crabtree G.R.
Genes Dev.16:2509-2517(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE BRAIN BAF53 COMPLEX WITH ACTB; ARID1A; SMARCA2; SMARCA4; SMARCB1; SMARCC1; SMARCC2; SMARCD2 AND SMARCE1;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
6.

"An essential switch in subunit composition of a chromatin remodeling complex during neural development."
Lessard J. , Wu J.I. , Ranish J.A. , Wan M. , Winslow M.M. , Staahl B.T. , Wu H. , Aebersold R. , Graef I.A. , Crabtree G.R.
Neuron55:201-215(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE NBAF AND NPBAF COMPLEXES;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE NBAF COMPLEX;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
7.

"Regulation of dendritic development by neuron-specific chromatin remodeling complexes."
Wu J.I. , Lessard J. , Olave I.A. , Qiu Z. , Ghosh A. , Graef I.A. , Crabtree G.R.
Neuron56:94-108(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;IDENTIFICATION IN THE NBAF COMPLEX

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