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Index > Protein center > CHRM1(Gene name) > Human
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  • CHRM1 (Gene name),
  • Muscarinic acetylcholine receptor M1 (Protein name ),  ACM1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CHRM1;
    Protein name:
    Muscarinic acetylcholine receptor M1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with GPRASP2.
    Function:
    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    460
    Sequence:
    50:
    MNTSAPPAVS | PNITVLAPGK | GPWQVAFIGI | TTGLLSLATV | TGNLLVLISF | 
    100:
    KVNTELKTVN | NYFLLSLACA | DLIIGTFSMN | LYTTYLLMGH | WALGTLACDL | 
    150:
    WLALDYVASN | ASVMNLLLIS | FDRYFSVTRP | LSYRAKRTPR | RAALMIGLAW | 
    200:
    LVSFVLWAPA | ILFWQYLVGE | RTVLAGQCYI | QFLSQPIITF | GTAMAAFYLP | 
    250:
    VTVMCTLYWR | IYRETENRAR | ELAALQGSET | PGKGGGSSSS | SERSQPGAEG | 
    300:
    SPETPPGRCC | RCCRAPRLLQ | AYSWKEEEEE | DEGSMESLTS | SEGEEPGSEV | 
    350:
    VIKMPMVDPE | AQAPTKQPPR | SSPNTVKRPT | KKGRDRAGKG | QKPRGKEQLA | 
    400:
    KRKTFSLVKE | KKAARTLSAI | LLAFILTWTP | YNIMVLVSTF | CKDCVPETLW | 
    450:
    ELGYWLCYVN | STINPMCYAL | CNKAFRDTFR | LLLLCRWDKR | RWRKIPKRPG | 
    460:
    SVHRTPSRQC | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    String:
    MIM:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Muscarinic acetylcholine receptor M1
    ELISA Kit for Human Muscarinic acetylcholine receptor M1
    ELISA Kit for Human Muscarinic acetylcholine receptor M1
    ELISA Kit for Human Muscarinic acetylcholine receptor M1
    CLIA Kit for Human Muscarinic acetylcholine receptor M1
    CLIA Kit for Human Muscarinic acetylcholine receptor M1
    CLIA Kit for Human Muscarinic acetylcholine receptor M1
    CLIA Kit for Human Muscarinic acetylcholine receptor M1
    Polyclonal Antibody for Human Muscarinic acetylcholine receptor M1
    Polyclonal Antibody for Human Muscarinic acetylcholine receptor M1
    Polyclonal Antibody for Human Muscarinic acetylcholine receptor M1
    Polyclonal Antibody for Human Muscarinic acetylcholine receptor M1
    Monoclonal Antibody for Human Muscarinic acetylcholine receptor M1
    Monoclonal Antibody for Human Muscarinic acetylcholine receptor M1
    Monoclonal Antibody for Human Muscarinic acetylcholine receptor M1
    Monoclonal Antibody for Human Muscarinic acetylcholine receptor M1
    Protein for Human Muscarinic acetylcholine receptor M1
    Protein for Human Muscarinic acetylcholine receptor M1
    Protein for Human Muscarinic acetylcholine receptor M1
    Protein for Human Muscarinic acetylcholine receptor M1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor."
      Allard W.J. , Sigal I.S. , Dixon R.A.F.
      Nucleic Acids Res.15:10604-10604(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification."
      Chapman C.G. , Browne M.J.
      Nucleic Acids Res.18:2191-2191(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors."
      Peralta E.G. , Ashkenazi A. , Winslow J.W. , Smith D.H. , Ramachandran J. , Capon D.J.
      EMBO J.6:3923-3929(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Cloning Cholinergic Receptors in Human Keratinocytes."
      Arredondo J. , Grando S.A.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    5. 5.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    8. 8.
      "Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor."
      Arden J.R. , Nagata O. , Shockley M.S. , Philip M. , Lameh J. , Sadee W.
      Biochem. Biophys. Res. Commun.188:1111-1115(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
    9. 9.
      "Identification of a novel family of G protein-coupled receptor associated sorting proteins."
      Simonin F. , Karcher P. , Boeuf J.J.-M. , Matifas A. , Kieffer B.L.
      J. Neurochem.89:766-775(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GPRASP2
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