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Index > Protein center > THEM5(Gene name) > Human
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  • THEM5 (Gene name),
  • Acyl-coenzyme A thioesterase THEM5 (Protein name ),  ACO15_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    THEM5(ACOT15);
    Protein name:
    Acyl-coenzyme A thioesterase THEM5(Acyl-CoA thioesterase THEM5);
    Alternative:
    Thioesterase superfamily member 5;Acyl-coenzyme A thioesterase 15;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function.
    Subcellular Location:
    Mitochondrion matrix
    Protein Attributes:
    Sequence length:
    247
    Sequence:
    50:
    MIRRCFQVAA | RLGHHRGLLE | APRILPRLNP | ASAFGSSTDS | MFSRFLPEKT | 
    100:
    DLKDYALPNA | SWCSDMLSLY | QEFLEKTKSS | GWIKLPSFKS | NRDHIRGLKL | 
    150:
    PSGLAVSSDK | GDCRIFTRCI | QVEGQGFEYV | IFFQPTQKKS | VCLFQPGSYL | 
    200:
    EGPPGFAHGG | SLAAMMDETF | SKTAFLAGEG | LFTLSLNIRF | KNLIPVDSLV | 
    247:
    VMDVELDKIE | DQKLYMSCIA | HSRDQQTVYA | KSSGVFLQLQ | LEEESPQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Acyl-CoA thioesterase THEM5
    ELISA Kit for Human Acyl-CoA thioesterase THEM5
    ELISA Kit for Human Acyl-CoA thioesterase THEM5
    ELISA Kit for Human Acyl-CoA thioesterase THEM5
    CLIA Kit for Human Acyl-CoA thioesterase THEM5
    CLIA Kit for Human Acyl-CoA thioesterase THEM5
    CLIA Kit for Human Acyl-CoA thioesterase THEM5
    CLIA Kit for Human Acyl-CoA thioesterase THEM5
    Polyclonal Antibody for Human Acyl-CoA thioesterase THEM5
    Polyclonal Antibody for Human Acyl-CoA thioesterase THEM5
    Polyclonal Antibody for Human Acyl-CoA thioesterase THEM5
    Polyclonal Antibody for Human Acyl-CoA thioesterase THEM5
    Monoclonal Antibody for Human Acyl-CoA thioesterase THEM5
    Monoclonal Antibody for Human Acyl-CoA thioesterase THEM5
    Monoclonal Antibody for Human Acyl-CoA thioesterase THEM5
    Monoclonal Antibody for Human Acyl-CoA thioesterase THEM5
    Protein for Human Acyl-CoA thioesterase THEM5
    Protein for Human Acyl-CoA thioesterase THEM5
    Protein for Human Acyl-CoA thioesterase THEM5
    Protein for Human Acyl-CoA thioesterase THEM5

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-206
      tissue: Tongue.
    2. 2.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT VAL-206
      tissue: Heart.
      tissue: Lung.
    4. 4.
      "Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development."
      Zhuravleva E. , Gut H. , Hynx D. , Marcellin D. , Bleck C.K. , Genoud C. , Cron P. , Keusch J.J. , Dummler B. , Esposti M.D. , Hemmings B.A.
      Mol. Cell. Biol.32:2685-2697(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 35-247;CATALYTIC ACTIVITY;FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF GLY-160; ASP-167 AND THR-183
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