Gene name:
ACSS1 (ACAS2L;KIAA1846) ;
Protein name:
Acetyl-coenzyme A synthetase 2-like, mitochondrial ;
Alternative:
Acetyl-CoA synthetase 2 (AceCS2) ;Acetate--CoA ligase 2 ;Acyl-CoA synthetase short-chain family member 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with SIRT3.
Function:
Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
Subcellular Location:
Mitochondrion matrix
Protein Attributes:
50:
MAARTLGRGV | GRLLGSLRGL | SGQPARPPCG | VSAPRRAASG | PSGSAPAVAA |
100:
AAAQPGSYPA | LSAQAAREPA | AFWGPLARDT | LVWDTPYHTV | WDCDFSTGKI |
150:
GWFLGGQLNV | SVNCLDQHVR | KSPESVALIW | ERDEPGTEVR | ITYRELLETT |
200:
CRLANTLKRH | GVHRGDRVAI | YMPVSPLAVA | AMLACARIGA | VHTVIFAGFS |
250:
AESLAGRIND | AKCKVVITFN | QGLRGGRVVE | LKKIVDEAVK | HCPTVQHVLV |
300:
AHRTDNKVHM | GDLDVPLEQE | MAKEDPVCAP | ESMGSEDMLF | MLYTSGSTGM |
350:
PKGIVHTQAG | YLLYAALTHK | LVFDHQPGDI | FGCVADIGWI | TGHSYVVYGP |
400:
LCNGATSVLF | ESTPVYPNAG | RYWETVERLK | INQFYGAPTA | VRLLLKYGDA |
450:
WVKKYDRSSL | RTLGSVGEPI | NCEAWEWLHR | VVGDSRCTLV | DTWWQTETGG |
500:
ICIAPRPSEE | GAEILPAMAM | RPFFGIVPVL | MDEKGSVVEG | SNVSGALCIS |
550:
QAWPGMARTI | YGDHQRFVDA | YFKAYPGYYF | TGDGAYRTEG | GYYQITGRMD |
600:
DVINISGHRL | GTAEIEDAIA | DHPAVPESAV | IGYPHDIKGE | AAFAFIVVKD |
650:
SAGDSDVVVQ | ELKSMVATKI | AKYAVPDEIL | VVKRLPKTRS | GKVMRRLLRK |
689:
IITSEAQELG | DTTTLEDPSI | IAEILSVYQK | CKDKQAAAK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
ELISA Kit for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
CLIA Kit for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
CLIA Kit for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
Polyclonal Antibody for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
Polyclonal Antibody for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
Monoclonal Antibody for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
Monoclonal Antibody for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
Protein for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
Protein for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
R&D Technical Data
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Precision
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Recovery
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Linearity
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Nat. Genet.36:40-45(2004)
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[
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-689 (ISOFORM 1);VARIANT MET-488
tissue :
Placenta .
tissue :
Thalamus .
tissue :
Tongue .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT MET-488
tissue :
Brain .
tissue :
Testis .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 336-689 (ISOFORM 1)
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION AT LYS-642;MUTAGENESIS OF LYS-642;FUNCTION;ENZYME REGULATION;PROTEIN SEQUENCE OF N-TERMINUS;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-396;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Westphal C.H.
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Perni R.B.
J. Biol. Chem.284:24394-24405(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 638-649 IN COMPLEX WITH SIRT3