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Index > Protein center > ACSS1(Gene name) > Human
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  • ACSS1 (Gene name),
  • Acetyl-coenzyme A synthetase 2-like, mitochondrial (Protein name ),  ACS2L_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ACSS1(ACAS2L;KIAA1846);
    Protein name:
    Acetyl-coenzyme A synthetase 2-like, mitochondrial;
    Alternative:
    Acetyl-CoA synthetase 2(AceCS2);Acetate--CoA ligase 2;Acyl-CoA synthetase short-chain family member 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SIRT3.
    Function:
    Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).
    Subcellular Location:
    Mitochondrion matrix
    Protein Attributes:
    Sequence length:
    689
    Sequence:
    50:
    MAARTLGRGV | GRLLGSLRGL | SGQPARPPCG | VSAPRRAASG | PSGSAPAVAA | 
    100:
    AAAQPGSYPA | LSAQAAREPA | AFWGPLARDT | LVWDTPYHTV | WDCDFSTGKI | 
    150:
    GWFLGGQLNV | SVNCLDQHVR | KSPESVALIW | ERDEPGTEVR | ITYRELLETT | 
    200:
    CRLANTLKRH | GVHRGDRVAI | YMPVSPLAVA | AMLACARIGA | VHTVIFAGFS | 
    250:
    AESLAGRIND | AKCKVVITFN | QGLRGGRVVE | LKKIVDEAVK | HCPTVQHVLV | 
    300:
    AHRTDNKVHM | GDLDVPLEQE | MAKEDPVCAP | ESMGSEDMLF | MLYTSGSTGM | 
    350:
    PKGIVHTQAG | YLLYAALTHK | LVFDHQPGDI | FGCVADIGWI | TGHSYVVYGP | 
    400:
    LCNGATSVLF | ESTPVYPNAG | RYWETVERLK | INQFYGAPTA | VRLLLKYGDA | 
    450:
    WVKKYDRSSL | RTLGSVGEPI | NCEAWEWLHR | VVGDSRCTLV | DTWWQTETGG | 
    500:
    ICIAPRPSEE | GAEILPAMAM | RPFFGIVPVL | MDEKGSVVEG | SNVSGALCIS | 
    550:
    QAWPGMARTI | YGDHQRFVDA | YFKAYPGYYF | TGDGAYRTEG | GYYQITGRMD | 
    600:
    DVINISGHRL | GTAEIEDAIA | DHPAVPESAV | IGYPHDIKGE | AAFAFIVVKD | 
    650:
    SAGDSDVVVQ | ELKSMVATKI | AKYAVPDEIL | VVKRLPKTRS | GKVMRRLLRK | 
    689:
    IITSEAQELG | DTTTLEDPSI | IAEILSVYQK | CKDKQAAAK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
    ELISA Kit for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
    CLIA Kit for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
    CLIA Kit for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
    Polyclonal Antibody for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
    Polyclonal Antibody for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
    Monoclonal Antibody for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
    Monoclonal Antibody for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
    Protein for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial
    Protein for Human Acetyl-coenzyme A synthetase 2-like, mitochondrial

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-689 (ISOFORM 1);VARIANT MET-488
      tissue: Placenta.
      tissue: Thalamus.
      tissue: Tongue.
    2. 2.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT MET-488
      tissue: Brain.
      tissue: Testis.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Nakayama M. , Nakajima D. , Kikuno R. , Ohara O.
      DNA Res.8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 336-689 (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
      DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    7. 7.
      "Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2."
      Schwer B. , Bunkenborg J. , Verdin R.O. , Andersen J.S. , Verdin E.
      Proc. Natl. Acad. Sci. U.S.A.103:10224-10229(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-642;MUTAGENESIS OF LYS-642;FUNCTION;ENZYME REGULATION;PROTEIN SEQUENCE OF N-TERMINUS;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
    8. 8.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-396;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Crystal structures of human SIRT3 displaying substrate-induced conformational changes."
      Jin L. , Wei W. , Jiang Y. , Peng H. , Cai J. , Mao C. , Dai H. , Choy W. , Bemis J.E. , Jirousek M.R. , Milne J.C. , Westphal C.H. , Perni R.B.
      J. Biol. Chem.284:24394-24405(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 638-649 IN COMPLEX WITH SIRT3
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