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Index > Protein center > ACSL4(Gene name) > Human
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  • ACSL4 (Gene name),
  • Long-chain-fatty-acid--CoA ligase 4 (Protein name ),  ACSL4_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    ACSL4(ACS4;FACL4;LACS4);
    Protein name:
    Long-chain-fatty-acid--CoA ligase 4;
    Alternative:
    Long-chain acyl-CoA synthetase 4(LACS 4);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
    Subcellular Location:
    Mitochondrion outer membrane Single-pass type III membrane protein Peroxisome membrane Single-pass type III membrane protein Microsome membrane Single-pass type III membrane protein Endoplasmic reticulum membrane Single-pass type III membrane protein
    Protein Attributes:
    Sequence length:
    711
    Sequence:
    50:
    MKLKLNVLTI | ILLPVHLLIT | IYSALIFIPW | YFLTNAKKKN | AMAKRIKAKP | 
    100:
    TSDKPGSPYR | SVTHFDSLAV | IDIPGADTLD | KLFDHAVSKF | GKKDSLGTRE | 
    150:
    ILSEENEMQP | NGKVFKKLIL | GNYKWMNYLE | VNRRVNNFGS | GLTALGLKPK | 
    200:
    NTIAIFCETR | AEWMIAAQTC | FKYNFPLVTL | YATLGKEAVV | HGLNESEASY | 
    250:
    LITSVELLES | KLKTALLDIS | CVKHIIYVDN | KAINKAEYPE | GFEIHSMQSV | 
    300:
    EELGSNPENL | GIPPSRPTPS | DMAIVMYTSG | STGRPKGVMM | HHSNLIAGMT | 
    350:
    GQCERIPGLG | PKDTYIGYLP | LAHVLELTAE | ISCFTYGCRI | GYSSPLTLSD | 
    400:
    QSSKIKKGSK | GDCTVLKPTL | MAAVPEIMDR | IYKNVMSKVQ | EMNYIQKTLF | 
    450:
    KIGYDYKLEQ | IKKGYDAPLC | NLLLFKKVKA | LLGGNVRMML | SGGAPLSPQT | 
    500:
    HRFMNVCFCC | PIGQGYGLTE | SCGAGTVTEV | TDYTTGRVGA | PLICCEIKLK | 
    550:
    DWQEGGYTIN | DKPNPRGEIV | IGGQNISMGY | FKNEEKTAED | YSVDENGQRW | 
    600:
    FCTGDIGEFH | PDGCLQIIDR | KKDLVKLQAG | EYVSLGKVEA | ALKNCPLIDN | 
    650:
    ICAFAKSDQS | YVISFVVPNQ | KRLTLLAQQK | GVEGTWVDIC | NNPAMEAEIL | 
    700:
    KEIREAANAM | KLERFEIPIK | VRLSPEPWTP | ETGLVTDAFK | LKRKELRNHY | 
    711:
    LKDIERMYGG | K
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Long-chain-fatty-acid--CoA ligase 4
    ELISA Kit for Human Long-chain-fatty-acid--CoA ligase 4
    ELISA Kit for Human Long-chain-fatty-acid--CoA ligase 4
    CLIA Kit for Human Long-chain-fatty-acid--CoA ligase 4
    CLIA Kit for Human Long-chain-fatty-acid--CoA ligase 4
    CLIA Kit for Human Long-chain-fatty-acid--CoA ligase 4
    Polyclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 4
    Polyclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 4
    Polyclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 4
    Monoclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 4
    Monoclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 4
    Monoclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 4
    Protein for Human Long-chain-fatty-acid--CoA ligase 4
    Protein for Human Long-chain-fatty-acid--CoA ligase 4
    Protein for Human Long-chain-fatty-acid--CoA ligase 4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4)."
      Cao Y. , Traer E. , Zimmerman G.A. , McIntyre T.M. , Prescott S.M.
      Genomics49:327-330(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
    2. 2.
      "FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation."
      Piccini M. , Vitelli F. , Bruttini M. , Pober B.R. , Jonsson J.J. , Villanova M. , Zollo M. , Borsani G. , Ballabio A. , Renieri A.
      Genomics47:350-358(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT)
      tissue: Placenta.
      tissue: Retina.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT)
      tissue: Stomach.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT)
      tissue: Testis.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation."
      Meloni I. , Muscettola M. , Raynaud M. , Longo I. , Bruttini M. , Moizard M.-P. , Gomot M. , Chelly J. , des Portes V. , Fryns J.-P. , Ropers H.-H. , Magi B. , Bellan C. , Volpi N. , Yntema H.G. , Lewis S.E. , Schaffer J.E. , Renieri A.
      Nat. Genet.30:436-440(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MRX63 SER-570
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] CYS-133
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