Gene name:
ACSL5 (UNQ633/PRO1250;ACS5;FACL5) ;
Protein name:
Long-chain-fatty-acid--CoA ligase 5 ;
Alternative:
Long-chain acyl-CoA synthetase 5 (LACS 5) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Subcellular Location:
Mitochondrion
Endoplasmic reticulum
Mitochondrion outer membrane
Single-pass type III membrane protein
Endoplasmic reticulum membrane
Single-pass type III membrane protein
Protein Attributes:
50:
MLFIFNFLFS | PLPTPALICI | LTFGAAIFLW | LITRPQPVLP | LLDLNNQSVG |
100:
IEGGARKGVS | QKNNDLTSCC | FSDAKTMYEV | FQRGLAVSDN | GPCLGYRKPN |
150:
QPYRWLSYKQ | VSDRAEYLGS | CLLHKGYKSS | PDQFVGIFAQ | NRPEWIISEL |
200:
ACYTYSMVAV | PLYDTLGPEA | IVHIVNKADI | AMVICDTPQK | ALVLIGNVEK |
250:
GFTPSLKVII | LMDPFDDDLK | QRGEKSGIEI | LSLYDAENLG | KEHFRKPVPP |
300:
SPEDLSVICF | TSGTTGDPKG | AMITHQNIVS | NAAAFLKCVE | HAYEPTPDDV |
350:
AISYLPLAHM | FERIVQAVVY | SCGARVGFFQ | GDIRLLADDM | KTLKPTLFPA |
400:
VPRLLNRIYD | KVQNEAKTPL | KKFLLKLAVS | SKFKELQKGI | IRHDSFWDKL |
450:
IFAKIQDSLG | GRVRVIVTGA | APMSTSVMTF | FRAAMGCQVY | EAYGQTECTG |
500:
GCTFTLPGDW | TSGHVGVPLA | CNYVKLEDVA | DMNYFTVNNE | GEVCIKGTNV |
550:
FKGYLKDPEK | TQEALDSDGW | LHTGDIGRWL | PNGTLKIIDR | KKNIFKLAQG |
600:
EYIAPEKIEN | IYNRSQPVLQ | IFVHGESLRS | SLVGVVVPDT | DVLPSFAAKL |
650:
GVKGSFEELC | QNQVVREAIL | EDLQKIGKES | GLKTFEQVKA | IFLHPEPFSI |
683:
ENGLLTPTLK | AKRGELSKYF | RTQIDSLYEH | IQD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Human Long-chain-fatty-acid--CoA ligase 5
ELISA Kit for Human Long-chain-fatty-acid--CoA ligase 5
ELISA Kit for Human Long-chain-fatty-acid--CoA ligase 5
CLIA Kit for Human Long-chain-fatty-acid--CoA ligase 5
CLIA Kit for Human Long-chain-fatty-acid--CoA ligase 5
CLIA Kit for Human Long-chain-fatty-acid--CoA ligase 5
Polyclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
Polyclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
Polyclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
Monoclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
Monoclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
Monoclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
Protein for Human Long-chain-fatty-acid--CoA ligase 5
Protein for Human Long-chain-fatty-acid--CoA ligase 5
Protein for Human Long-chain-fatty-acid--CoA ligase 5
R&D Technical Data
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Precision
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Recovery
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Linearity
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;SUBCELLULAR LOCATION;ALTERNATIVE SPLICING;BIOPHYSICOCHEMICAL PROPERTIES
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Hepatoma .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Liver .
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Colon .
8.
"Human FACL5 (or ACS5)."
Yamashita Y.
Submitted (1999-10) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2)
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] ARG-388 AND ASP-466