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Index > Protein center > ACSL5(Gene name) > Human
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  • ACSL5 (Gene name),
  • Long-chain-fatty-acid--CoA ligase 5 (Protein name ),  ACSL5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ACSL5(UNQ633/PRO1250;ACS5;FACL5);
    Protein name:
    Long-chain-fatty-acid--CoA ligase 5;
    Alternative:
    Long-chain acyl-CoA synthetase 5(LACS 5);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
    Subcellular Location:
    Mitochondrion Endoplasmic reticulum Mitochondrion outer membrane Single-pass type III membrane protein Endoplasmic reticulum membrane Single-pass type III membrane protein
    Protein Attributes:
    Sequence length:
    683
    Sequence:
    50:
    MLFIFNFLFS | PLPTPALICI | LTFGAAIFLW | LITRPQPVLP | LLDLNNQSVG | 
    100:
    IEGGARKGVS | QKNNDLTSCC | FSDAKTMYEV | FQRGLAVSDN | GPCLGYRKPN | 
    150:
    QPYRWLSYKQ | VSDRAEYLGS | CLLHKGYKSS | PDQFVGIFAQ | NRPEWIISEL | 
    200:
    ACYTYSMVAV | PLYDTLGPEA | IVHIVNKADI | AMVICDTPQK | ALVLIGNVEK | 
    250:
    GFTPSLKVII | LMDPFDDDLK | QRGEKSGIEI | LSLYDAENLG | KEHFRKPVPP | 
    300:
    SPEDLSVICF | TSGTTGDPKG | AMITHQNIVS | NAAAFLKCVE | HAYEPTPDDV | 
    350:
    AISYLPLAHM | FERIVQAVVY | SCGARVGFFQ | GDIRLLADDM | KTLKPTLFPA | 
    400:
    VPRLLNRIYD | KVQNEAKTPL | KKFLLKLAVS | SKFKELQKGI | IRHDSFWDKL | 
    450:
    IFAKIQDSLG | GRVRVIVTGA | APMSTSVMTF | FRAAMGCQVY | EAYGQTECTG | 
    500:
    GCTFTLPGDW | TSGHVGVPLA | CNYVKLEDVA | DMNYFTVNNE | GEVCIKGTNV | 
    550:
    FKGYLKDPEK | TQEALDSDGW | LHTGDIGRWL | PNGTLKIIDR | KKNIFKLAQG | 
    600:
    EYIAPEKIEN | IYNRSQPVLQ | IFVHGESLRS | SLVGVVVPDT | DVLPSFAAKL | 
    650:
    GVKGSFEELC | QNQVVREAIL | EDLQKIGKES | GLKTFEQVKA | IFLHPEPFSI | 
    683:
    ENGLLTPTLK | AKRGELSKYF | RTQIDSLYEH | IQD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    Pfam:
    UniGene:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Long-chain-fatty-acid--CoA ligase 5
    ELISA Kit for Human Long-chain-fatty-acid--CoA ligase 5
    ELISA Kit for Human Long-chain-fatty-acid--CoA ligase 5
    CLIA Kit for Human Long-chain-fatty-acid--CoA ligase 5
    CLIA Kit for Human Long-chain-fatty-acid--CoA ligase 5
    CLIA Kit for Human Long-chain-fatty-acid--CoA ligase 5
    Polyclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
    Polyclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
    Polyclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
    Monoclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
    Monoclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
    Monoclonal Antibody for Human Long-chain-fatty-acid--CoA ligase 5
    Protein for Human Long-chain-fatty-acid--CoA ligase 5
    Protein for Human Long-chain-fatty-acid--CoA ligase 5
    Protein for Human Long-chain-fatty-acid--CoA ligase 5

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;SUBCELLULAR LOCATION;ALTERNATIVE SPLICING;BIOPHYSICOCHEMICAL PROPERTIES
      tissue: Small intestine mucosa.
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Hepatoma.
    4. 4.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Liver.
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Colon.
    8. 8.
      "Human FACL5 (or ACS5)."
      Yamashita Y.
      Submitted (1999-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2)
    9. 9.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide."
      Mashima T. , Sato S. , Okabe S. , Miyata S. , Matsuura M. , Sugimoto Y. , Tsuruo T. , Seimiya H.
      Cancer Sci.100:1556-1562(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions."
      Mashima T. , Sato S. , Sugimoto Y. , Tsuruo T. , Seimiya H.
      Oncogene28:9-19(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-388 AND ASP-466
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