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Index > Protein center > Acsl5(Gene name) > Rat
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  • Acsl5 (Gene name),
  • Long-chain-fatty-acid--CoA ligase 5 (Protein name ),  ACSL5_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Acsl5(Acs5;Facl5);
    Protein name:
    Long-chain-fatty-acid--CoA ligase 5;
    Alternative:
    Long-chain acyl-CoA synthetase 5(LACS 5);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (By similarity). May have a role in the survival of glioma cells (By similarity). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. It was suggested that it may also stimulate fatty acid oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids.
    Subcellular Location:
    Mitochondrion Endoplasmic reticulum Mitochondrion outer membrane Single-pass type III membrane protein Endoplasmic reticulum membrane Single-pass type III membrane protein
    Protein Attributes:
    Sequence length:
    683
    Sequence:
    50:
    MLFIFNFLFS | PLPTPALICL | LTFGTAIFLW | LINRPQPVLP | LIDLDNQSVG | 
    100:
    IEGGARRGAF | QKNNDLILYY | FSDAKTLYEV | FQRGLAVSDN | GPCLGYRKPN | 
    150:
    QPYKWISYKQ | VSDRAEYLGS | CLLHKGYKPS | QDQFIGIFAQ | NRPEWVISEL | 
    200:
    ACYTYSMVAV | PLYDTLGAEA | IIYVINRADI | SVVICDTPQK | ATMLIENVEK | 
    250:
    DLTPGLKTVI | LMDPFDDDLM | KRGEKCGIEM | LSLHDAENLG | KENFKKPMPP | 
    300:
    NPEDLSVICF | TSGTTGDPKG | AMLTHQNIVS | NMAAFLKFLE | PIFQPTPEDV | 
    350:
    TISYLPLAHM | FERLVQGVIF | SCGGKIGFFQ | GDIRLLPDDM | KALKPTVFPT | 
    400:
    VPRLLNRVYD | KVQNEAKTPL | KKFLLNLAII | SKFNEVRNGI | IRRNSLWDKL | 
    450:
    VFSKIQSSLG | GKVRLMITGA | APISTPVLTF | FRAAMGCWVF | EAYGQTECTA | 
    500:
    GCSITSPGDW | TAGHVGTPVS | CNFVKLEDVA | DMNYFSVNNE | GEICIKGNNV | 
    550:
    FKGYLKDPEK | TQEVLDKDGW | LHTGDIGRWL | PNGTLKIIDR | KKNIFKLAQG | 
    600:
    EYIAPEKIEN | VYSRSRPILQ | VFVHGESLRS | FLIGVVVPDP | ESLPSFAAKI | 
    650:
    GVKGSFEELC | QNQCVKKAIL | EDLQKVGKEG | GLKSFEQVKS | IFVHPEPFSI | 
    683:
    ENGLLTPTLK | AKRVELAKFF | QTQIKSLYES | IEE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
    ELISA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
    ELISA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
    CLIA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
    CLIA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
    CLIA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
    Polyclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
    Polyclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
    Polyclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
    Monoclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
    Monoclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
    Monoclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
    Protein for Rat Long-chain-fatty-acid--CoA ligase 5
    Protein for Rat Long-chain-fatty-acid--CoA ligase 5
    Protein for Rat Long-chain-fatty-acid--CoA ligase 5

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes."
      Oikawa E. , Iijima H. , Suzuki T. , Sasano H. , Sato H. , Kamataki A. , Nagura H. , Kang M.-J. , Fujino T. , Suzuki H. , Yamamoto T.T.
      J. Biochem.124:679-685(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
    2. 2.
      "Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6."
      Van Horn C.G. , Caviglia J.M. , Li L.O. , Wang S. , Granger D.A. , Coleman R.A.
      Biochemistry44:1635-1642(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES
      tissue: Brain.
    3. 3.
      "Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells."
      Mashek D.G. , McKenzie M.A. , Van Horn C.G. , Coleman R.A.
      J. Biol. Chem.281:945-950(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INDUCTION
    4. 4.
      "Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation."
      Zhou Y. , Abidi P. , Kim A. , Chen W. , Huang T.-T. , Kraemer F.B. , Liu J.
      Arterioscler. Thromb. Vasc. Biol.27:2198-2205(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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