Gene name:
Acsl5 (Acs5;Facl5) ;
Protein name:
Long-chain-fatty-acid--CoA ligase 5 ;
Alternative:
Long-chain acyl-CoA synthetase 5 (LACS 5) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL at the villus tip of the crypt-villus axis of the small intestine (By similarity). May have a role in the survival of glioma cells (By similarity). May activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. It was suggested that it may also stimulate fatty acid oxidation. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids.
Subcellular Location:
Mitochondrion
Endoplasmic reticulum
Mitochondrion outer membrane
Single-pass type III membrane protein
Endoplasmic reticulum membrane
Single-pass type III membrane protein
Protein Attributes:
50:
MLFIFNFLFS | PLPTPALICL | LTFGTAIFLW | LINRPQPVLP | LIDLDNQSVG |
100:
IEGGARRGAF | QKNNDLILYY | FSDAKTLYEV | FQRGLAVSDN | GPCLGYRKPN |
150:
QPYKWISYKQ | VSDRAEYLGS | CLLHKGYKPS | QDQFIGIFAQ | NRPEWVISEL |
200:
ACYTYSMVAV | PLYDTLGAEA | IIYVINRADI | SVVICDTPQK | ATMLIENVEK |
250:
DLTPGLKTVI | LMDPFDDDLM | KRGEKCGIEM | LSLHDAENLG | KENFKKPMPP |
300:
NPEDLSVICF | TSGTTGDPKG | AMLTHQNIVS | NMAAFLKFLE | PIFQPTPEDV |
350:
TISYLPLAHM | FERLVQGVIF | SCGGKIGFFQ | GDIRLLPDDM | KALKPTVFPT |
400:
VPRLLNRVYD | KVQNEAKTPL | KKFLLNLAII | SKFNEVRNGI | IRRNSLWDKL |
450:
VFSKIQSSLG | GKVRLMITGA | APISTPVLTF | FRAAMGCWVF | EAYGQTECTA |
500:
GCSITSPGDW | TAGHVGTPVS | CNFVKLEDVA | DMNYFSVNNE | GEICIKGNNV |
550:
FKGYLKDPEK | TQEVLDKDGW | LHTGDIGRWL | PNGTLKIIDR | KKNIFKLAQG |
600:
EYIAPEKIEN | VYSRSRPILQ | VFVHGESLRS | FLIGVVVPDP | ESLPSFAAKI |
650:
GVKGSFEELC | QNQCVKKAIL | EDLQKVGKEG | GLKSFEQVKS | IFVHPEPFSI |
683:
ENGLLTPTLK | AKRVELAKFF | QTQIKSLYES | IEE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
ELISA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
ELISA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
CLIA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
CLIA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
CLIA Kit for Rat Long-chain-fatty-acid--CoA ligase 5
Polyclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
Polyclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
Polyclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
Monoclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
Monoclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
Monoclonal Antibody for Rat Long-chain-fatty-acid--CoA ligase 5
Protein for Rat Long-chain-fatty-acid--CoA ligase 5
Protein for Rat Long-chain-fatty-acid--CoA ligase 5
Protein for Rat Long-chain-fatty-acid--CoA ligase 5
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes."
Oikawa E.
,
Iijima H.
,
Suzuki T.
,
Sasano H.
,
Sato H.
,
Kamataki A.
,
Nagura H.
,
Kang M.-J.
,
Fujino T.
,
Suzuki H.
,
Yamamoto T.T.
J. Biochem.124:679-685(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : BIOPHYSICOCHEMICAL PROPERTIES
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INDUCTION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION