ADAM22 ELISA Kit for Human(Homo sapiens) | EIAab.comADAM22 ELISA Kit for Human(Homo sapiens) | EIAab.com

Language:

[Sign in] [Register]

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > ADAM22(Gene name) > Human

Add your favorite

ADAM22 (Gene name),

Disintegrin and metalloproteinase domain-containing protein 22 (Protein name ), ADA22_HUMAN from NCBI database.

top

Come back to page head.

|

General Annotation

|

Antigen Annotation

|

3D

|

Predicted Eptitope

|

Vaild Sequence

|

Related Databases

|

Feedback

Gene name:

ADAM22(MDC2);

Protein name:

Disintegrin and metalloproteinase domain-containing protein 22(ADAM 22);

Alternative:

Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2;Metalloproteinase-disintegrin ADAM22-3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with LGI1 and can bind to LGI4 (By similarity). Interacts through its C-terminal region with YWHAB/14-3-3 beta and YWHAZ/14-3-3 zeta but not with YWHAE/14-3-3 epsilon or YWHAH/14-3-3 eta.

Function:

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

906

Sequence:

50:

MQAAVAVSVP | FLLLCVLGTC | PPARCGQAGD | ASLMELEKRK | ENRFVERQSI |

100:

VPLRLIYRSG | GEDESRHDAL | DTRVRGDLGG | PQLTHVDQAS | FQVDAFGTSF |

150:

ILDVVLNHDL | LSSEYIERHI | EHGGKTVEVK | GGEHCYYQGH | IRGNPDSFVA |

200:

LSTCHGLHGM | FYDGNHTYLI | EPEENDTTQE | DFHFHSVYKS | RLFEFSLDDL |

250:

PSEFQQVNIT | PSKFILKPRP | KRSKRQLRRY | PRNVEEETKY | IELMIVNDHL |

300:

MFKKHRLSVV | HTNTYAKSVV | NMADLIYKDQ | LKTRIVLVAM | ETWATDNKFA |

350:

ISENPLITLR | EFMKYRRDFI | KEKSDAVHLF | SGSQFESSRS | GAAYIGGICS |

400:

LLKGGGVNEF | GKTDLMAVTL | AQSLAHNIGI | ISDKRKLASG | ECKCEDTWSG |

450:

CIMGDTGYYL | PKKFTQCNIE | EYHDFLNSGG | GACLFNKPSK | LLDPPECGNG |

500:

FIETGEECDC | GTPAECVLEG | AECCKKCTLT | QDSQCSDGLC | CKKCKFQPMG |

550:

TVCREAVNDC | DIRETCSGNS | SQCAPNIHKM | DGYSCDGVQG | ICFGGRCKTR |

600:

DRQCKYIWGQ | KVTASDKYCY | EKLNIEGTEK | GNCGKDKDTW | IQCNKRDVLC |

650:

GYLLCTNIGN | IPRLGELDGE | ITSTLVVQQG | RTLNCSGGHV | KLEEDVDLGY |

700:

VEDGTPCGPQ | MMCLEHRCLP | VASFNFSTCL | SSKEGTICSG | NGVCSNELKC |

750:

VCNRHWIGSD | CNTYFPHNDD | AKTGITLSGN | GVAGTNIIIG | IIAGTILVLA |

800:

LILGITAWGY | KNYREQRQLP | QGDYVKKPGD | GDSFYSDIPP | GVSTNSASSS |

850:

KKRSNGLSHS | WSERIPDTKH | ISDICENGRP | RSNSWQGNLG | GNKKKIRGKR |

900:

FRPRSNSTET | LSPAKSPSSS | TGSIASSRKY | PYPMPPLPDE | DKKVNRQSAR |

906:

LWETSI

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

MIM:

SMR:

STRING:

9606.ENSP00000265727

KEGG:

Pfam:

UniGene:

String:

Uniprot:

FOR

ELISA Kit for Human ADAM 22

ELISA Kit for Human ADAM 22

CLIA Kit for Human ADAM 22

CLIA Kit for Human ADAM 22

Polyclonal Antibody for Human ADAM 22

Polyclonal Antibody for Human ADAM 22

Monoclonal Antibody for Human ADAM 22

Monoclonal Antibody for Human ADAM 22

Protein for Human ADAM 22

Protein for Human ADAM 22

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain."
Sagane K. , Ohya Y. , Hasegawa Y. , Tanaka I.
Biochem. J.334:93-98(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4)
tissue: Brain.
2.

"The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene in brain tissues and gliomas."
Harada T. , Nishie A. , Torigoe K. , Ikezaki K. , Shono T. , Maehara Y. , Kuwano M. , Wada M.
Jpn. J. Cancer Res.91:1001-1006(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
3.

"Isolation and tissue specific expression of novel ADAM family from 7q21.1 region."
Wada M. , Torigoe K. , Harada T. , Kuwano M.
Submitted (2000-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);VARIANT ARG-81
tissue: Brain.
4.

"The DNA sequence of human chromosome 7."
Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries."
Poindexter K. , Nelson N. , DuBose R.F. , Black R.A. , Cerretti D.P.
Gene237:61-70(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 40-906 (ISOFORM 1);VARIANT ARG-81
tissue: Cerebellum.
6.

"The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading."
Zhu P. , Sun Y. , Xu R. , Sang Y. , Zhao J. , Liu G. , Cai L. , Li C. , Zhao S.
Biochem. Biophys. Res. Commun.301:991-999(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH YWHAZ;MUTAGENESIS OF SER-834 AND SER-857
7.

"An unappreciated role for RNA surveillance."
Hillman R.T. , Green R.E. , Brenner S.E.
Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
8.

"ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3."
Zhu P. , Sang Y. , Xu H. , Zhao J. , Xu R. , Sun Y. , Xu T. , Wang X. , Chen L. , Feng H. , Li C. , Zhao S.
Biochem. Biophys. Res. Commun.331:938-946(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH YWHAB;MUTAGENESIS OF SER-834 AND SER-857
9.

"ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain."
D'Abaco G.M. , Ng K. , Paradiso L. , Godde N.J. , Kaye A. , Novak U.
Neurosurgery58:179-186(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
10.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-834;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM function."
Liu H. , Shim A.H. , He X.
J. Biol. Chem.284:29077-29086(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.36 ANGSTROMS) OF 233-736;GLYCOSYLATION AT ASN-519; ASN-634 AND ASN-675;DISULFIDE BONDS;FUNCTION

Product Feedback Wall

Hot Genes: Atf2 ASPRO ACE ALCAM C19orf80 Trap1a Gdf5

Top Searches: Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Alpha Tumor necrosis Asprosin TRAP1A

Why choose EIAAB: Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more

Further Information: About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved EIAab Email:eiaab@eiaab.com

鄂ICP备10015095号-1

鄂公网安备 42018502005535号