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Index > Protein center > Adam22(Gene name) > Mouse
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  • Adam22 (Gene name),
  • Disintegrin and metalloproteinase domain-containing protein 22 (Protein name ),  ADA22_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Adam22;
    Protein name:
    Disintegrin and metalloproteinase domain-containing protein 22(ADAM 22);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with LGI1. Can bind to LGI4.
    Function:
    Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    904
    Sequence:
    50:
    MQAAAAASFW | LLCVLGTCPL | ARCGRAGVAS | LKGLERGKEN | RFLERQSIIP | 
    100:
    LRLIYRLGGE | DETQHNQLDT | RVRGDPGGPQ | LTHVDKASFR | VDAFGTSFVL | 
    150:
    DVLLNHELLS | SGYVERQIEH | GGKVVENKGG | EHCYYQGQIR | GNPVSFVALS | 
    200:
    TCHGLHGMFY | DGNHTYLIEP | EENEKSQESS | HCHSVYKSRQ | FEFPLDDLPS | 
    250:
    EFQRVNITPP | QFILKPRLKR | RKRQLLRFPR | NVEEETKYIE | LMIVNDHLMF | 
    300:
    KKHRLSVVYT | NTYAKSVVNM | ADVIYKDQLK | TRIVLVAMET | WAADNKFAIS | 
    350:
    ENPLITLREF | MKYRRDFIKE | KADAVHLFSG | SQFESSRSGA | AYIGGICSLL | 
    400:
    RGGGVNEFGK | TDLMAVTLAQ | SLAHNVGIIS | DKRKLASGEC | KCEDTWSGCI | 
    450:
    MGDTGYYLPK | KFTQCNVEEY | HDFLNSGGGA | CLFNKPSKLL | DPPECGNGFI | 
    500:
    ETGEECDCGT | PAECALEGAE | CCKKCTLTQD | SQCSDGLCCK | KCKFQPLGTV | 
    550:
    CREAVNDCDI | REICSGNSSQ | CAPNVHKMDG | YSCDGTQGIC | FGGRCKTRDR | 
    600:
    QCKYIWGQKV | TASDRYCYEK | LNIEGTEKGN | CGKDKDTWTQ | CNKRDVLCGY | 
    650:
    LLCTNIGNIP | RLGELDGEIT | STLVVQQGRT | LNCSGAHVKL | EEDVDLGYVE | 
    700:
    DGTPCGPQMM | CLEHRCLPVA | SFNFSTCSSS | KAGTVCSGNG | VCSNELKCVC | 
    750:
    NRHWTGADCG | THFPHNDDAK | TGITLSGNGV | AGTNIIIGII | AGTILVLALI | 
    800:
    LGITAWGYKN | YREQRQLPQG | DYVKKPGDGD | SFYSDFPPGG | STNSASSSKK | 
    850:
    RSNGLSHSWS | ERIPDTKHIS | DICENGRPRS | NSWQGNMGGN | KKKIRGKRFR | 
    900:
    PRSNSTETLS | PAKSPSSSTG | SIASSRKYPY | PMPPLPDEGK | TAGRQSARLW | 
    904:
    ETSI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse ADAM 22
    ELISA Kit for Mouse ADAM 22
    CLIA Kit for Mouse ADAM 22
    CLIA Kit for Mouse ADAM 22
    Polyclonal Antibody for Mouse ADAM 22
    Polyclonal Antibody for Mouse ADAM 22
    Monoclonal Antibody for Mouse ADAM 22
    Monoclonal Antibody for Mouse ADAM 22
    Protein for Mouse ADAM 22
    Protein for Mouse ADAM 22

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23."
      Sagane K. , Yamazaki K. , Mizui Y. , Tanaka I.
      Gene236:79-86(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 17 AND 20)
      tissue: Brain.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-904 (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Embryo.
    3. 3.
      "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice."
      Sagane K. , Hayakawa K. , Kai J. , Hirohashi T. , Takahashi E. , Miyamoto N. , Ino M. , Oki T. , Yamazaki K. , Nagasu T.
      BMC Neurosci.6:33-33(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21);TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
    4. 4.
      "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission."
      Fukata Y. , Adesnik H. , Iwanaga T. , Bredt D.S. , Nicoll R.A. , Fukata M.
      Science313:1792-1795(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LGI1;MUTAGENESIS OF ASP-509
    5. 5.
      "LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11."
      Sagane K. , Ishihama Y. , Sugimoto H.
      Int. J. Biol. Sci.4:387-396(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LIGI1 AND LGI4
    6. 6.
      "ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons."
      Ogawa Y. , Oses-Prieto J. , Kim M.Y. , Horresh I. , Peles E. , Burlingame A.L. , Trimmer J.S. , Meijer D. , Rasband M.N.
      J. Neurosci.30:1038-1048(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KCNA2; LGI1; DLG2 AND DLG4;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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