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Index > Protein center > ADRA2B(Gene name) > Human
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  • ADRA2B (Gene name),
  • Alpha-2B adrenergic receptor (Protein name ),  ADA2B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ADRA2B(ADRA2L1;ADRA2RL1);
    Protein name:
    Alpha-2B adrenergic receptor;
    Alternative:
    Alpha-2B adrenoreceptor(Alpha-2B adrenoceptor;Alpha-2BAR);Alpha-2 adrenergic receptor subtype C2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    450
    Sequence:
    50:
    MDHQDPYSVQ | ATAAIAAAIT | FLILFTIFGN | ALVILAVLTS | RSLRAPQNLF | 
    100:
    LVSLAAADIL | VATLIIPFSL | ANELLGYWYF | RRTWCEVYLA | LDVLFCTSSI | 
    150:
    VHLCAISLDR | YWAVSRALEY | NSKRTPRRIK | CIILTVWLIA | AVISLPPLIY | 
    200:
    KGDQGPQPRG | RPQCKLNQEA | WYILASSIGS | FFAPCLIMIL | VYLRIYLIAK | 
    250:
    RSNRRGPRAK | GGPGQGESKQ | PRPDHGGALA | SAKLPALASV | ASAREVNGHS | 
    300:
    KSTGEKEEGE | TPEDTGTRAL | PPSWAALPNS | GQGQKEGVCG | ASPEDEAEEE | 
    350:
    EEEEEEEEEC | EPQAVPVSPA | SACSPPLQQP | QGSRVLATLR | GQVLLGRGVG | 
    400:
    AIGGQWWRRR | AQLTREKRFT | FVLAVVIGVF | VLCWFPFFFS | YSLGAICPKH | 
    450:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Alpha-2B adrenergic receptor
    ELISA Kit for Human Alpha-2B adrenergic receptor
    ELISA Kit for Human Alpha-2B adrenergic receptor
    ELISA Kit for Human Alpha-2B adrenergic receptor
    ELISA Kit for Human Alpha-2B adrenergic receptor
    CLIA Kit for Human Alpha-2B adrenergic receptor
    CLIA Kit for Human Alpha-2B adrenergic receptor
    CLIA Kit for Human Alpha-2B adrenergic receptor
    CLIA Kit for Human Alpha-2B adrenergic receptor
    CLIA Kit for Human Alpha-2B adrenergic receptor
    Polyclonal Antibody for Human Alpha-2B adrenergic receptor
    Polyclonal Antibody for Human Alpha-2B adrenergic receptor
    Polyclonal Antibody for Human Alpha-2B adrenergic receptor
    Polyclonal Antibody for Human Alpha-2B adrenergic receptor
    Polyclonal Antibody for Human Alpha-2B adrenergic receptor
    Monoclonal Antibody for Human Alpha-2B adrenergic receptor
    Monoclonal Antibody for Human Alpha-2B adrenergic receptor
    Monoclonal Antibody for Human Alpha-2B adrenergic receptor
    Monoclonal Antibody for Human Alpha-2B adrenergic receptor
    Monoclonal Antibody for Human Alpha-2B adrenergic receptor
    Protein for Human Alpha-2B adrenergic receptor
    Protein for Human Alpha-2B adrenergic receptor
    Protein for Human Alpha-2B adrenergic receptor
    Protein for Human Alpha-2B adrenergic receptor
    Protein for Human Alpha-2B adrenergic receptor

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2."
      Lomasney J.W. , Lorenz W. , Allen L.F. , King K. , Regan J.W. , Yang-Feng T.L. , Caron M.G. , Lefkowitz R.J.
      Proc. Natl. Acad. Sci. U.S.A.87:5094-5098(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-GLU-GLU-300 INS
    2. 2.
      "Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor."
      Weinshank R.L. , Zgombick J.M. , Macchi M. , Adham N. , Lichtblau H. , Branchek T.A. , Hartig P.R.
      Mol. Pharmacol.38:681-688(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-GLU-GLU-300 INS
    3. 3.
      "Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization."
      Small K.M. , Brown K.M. , Forbes S.L. , Liggett S.B.
      J. Biol. Chem.276:4917-4922(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene."
      Cayla C. , Heinonen P. , Viikari L. , Schaak S. , Snapir A. , Bouloumie A. , Karvonen M.K. , Pesonen U. , Scheinin M. , Paris H.
      Biochem. Pharmacol.67:469-478(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-GLU-GLU-300 INS
    5. 5.
      "Isolation of complete coding sequence for adrenergic receptor alpha 2B (ADRA2B)."
      Kopatz S.A. , Aronstam R.S. , Sharma S.V.
      Submitted (2004-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLU-GLU-GLU-300 INS
    6. 6.
      SeattleSNPs variation discovery resource
      Submitted (2005-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ALA-211; GLU-GLU-GLU-300 INS AND GLY-376;FRAMESHIFT POLYMORPHISM
    7. 7.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans."
      Chang A.C. , Ho T.F. , Chang N.-C.A.
      Biochem. Biophys. Res. Commun.172:817-823(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-386;VARIANT GLU-GLU-GLU-300 INS
    9. 9.
      "Rab26 modulates the cell surface transport of alpha2-adrenergic receptors from the Golgi."
      Li C. , Fan Y. , Lan T.H. , Lambert N.A. , Wu G.
      J. Biol. Chem.287:42784-42794(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAB26;SUBCELLULAR LOCATION
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