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Index > Protein center > SCIN(Gene name) > Bovine
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  • SCIN (Gene name),
  • Adseverin (Protein name ),  ADSV_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    SCIN;
    Protein name:
    Adseverin;
    Alternative:
    Scinderin(SC);
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    715
    Sequence:
    50:
    MAQGLYHEEF | ARAGKRAGLQ | VWRIEKLELV | PVPESAYGNF | YVGDAYLVLH | 
    100:
    TTQASRGFTY | RLHFWLGKEC | TQDESTAAAI | FTVQMDDYLG | GKPVQNRELQ | 
    150:
    GYESTDFVGY | FKGGLKYKAG | GVASGLNHVL | TNDLTAQRLL | HVKGRRVVRA | 
    200:
    TEVPLSWDSF | NKGDCFIIDL | GTEIYQWCGS | SCNKYERLKA | SQVAIGIRDN | 
    250:
    ERKGRAQLIV | VEEGSEPSEL | TKVLGEKPKL | RDGEDDDDIK | ADITNRKMAK | 
    300:
    LYMVSDASGS | MKVSLVAEEN | PFSMAMLLSE | ECFILDHGAA | KQIFVWKGKD | 
    350:
    ANPQERKAAM | KTAEEFLQQM | NYSTNTQIQV | LPEGGETPIF | KQFFKDWRDR | 
    400:
    DQSDGFGKVY | VTEKVAHVKQ | IPFDASKLHS | SPQMAAQHHV | VDDGSGKVQI | 
    450:
    WRVENNGRVE | IDRNSYGEFY | GGDCYIILYT | YPRGQIIYTW | QGANATRDEL | 
    500:
    TTSAFLTVQL | DRSLGGQAVQ | IRVSQGKEPA | HLLSLFKDKP | LIIYKNGTSK | 
    550:
    KEGQAPAPPI | RLFQVRRNLA | SITRIMEVDV | DANSLNSNDV | FVLKLRQNNG | 
    600:
    YIWIGKGSTQ | EEEKGAEYVA | SVLKCKTSTI | QEGKEPEEFW | NSLGGKKDYQ | 
    650:
    TSPLLESQAE | DHPPRLYGCS | NKTGRFIIEE | VPGEFTQDDL | AEDDVMLLDA | 
    700:
    WEQIFIWIGK | DANEVEKSES | LKSAKIYLET | DPSGRDKRTP | IVIIKQGHEP | 
    715:
    PTFTGWFLGW | DSSRW
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine Adseverin
    ELISA Kit for Bovine Adseverin
    ELISA Kit for Bovine Adseverin
    ELISA Kit for Bovine Adseverin
    ELISA Kit for Bovine Adseverin
    CLIA Kit for Bovine Adseverin
    CLIA Kit for Bovine Adseverin
    CLIA Kit for Bovine Adseverin
    CLIA Kit for Bovine Adseverin
    CLIA Kit for Bovine Adseverin
    Polyclonal Antibody for Bovine Adseverin
    Polyclonal Antibody for Bovine Adseverin
    Polyclonal Antibody for Bovine Adseverin
    Polyclonal Antibody for Bovine Adseverin
    Polyclonal Antibody for Bovine Adseverin
    Monoclonal Antibody for Bovine Adseverin
    Monoclonal Antibody for Bovine Adseverin
    Monoclonal Antibody for Bovine Adseverin
    Monoclonal Antibody for Bovine Adseverin
    Monoclonal Antibody for Bovine Adseverin
    Protein for Bovine Adseverin
    Protein for Bovine Adseverin
    Protein for Bovine Adseverin
    Protein for Bovine Adseverin
    Protein for Bovine Adseverin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Differential expression of bovine adseverin in adrenal gland revealed by in situ hybridization. Cloning of a cDNA for adseverin."
      Nakamura S. , Sakurai T. , Nonomura Y.
      J. Biol. Chem.269:5890-5896(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Adrenal medulla.
    2. 2.
      "Molecular cloning of bovine chromaffin cell scinderin (Sc) cDNA reveals actin and polyphosphoinositide domains."
      Marcu M.G. , Rodriguez del Castillo A. , Trifaro J.-M.
      Can. J. Physiol. Pharmacol.72:246-246(1994)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
      tissue: Adrenal medulla.
    3. 3.
      "The Ca2(+)-dependent actin filament-severing activity of 74-kDa protein (adseverin) resides in its NH2-terminal half."
      Sakurai T. , Kurokawa H. , Nonomura Y.
      J. Biol. Chem.266:4581-4585(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 364-375;DOMAIN FUNCTION
      tissue: Adrenal medulla.
    4. 4.
      "Comparison between the gelsolin and adseverin domain structure."
      Sakurai T. , Kurokawa H. , Nonomura Y.
      J. Biol. Chem.266:15979-15983(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 129-137 AND 243-247;FUNCTION
      tissue: Adrenal medulla.
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