Protein name:
Adipocyte enhancer-binding protein 1 (AE-binding protein 1) ;
Alternative:
Aortic carboxypeptidase-like protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By similarity). Binds to DNA in vitro.
Function:
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor.
Subcellular Location:
Isoform 2
Cytoplasm
Nucleus
Protein Attributes:
50:
MAAVRGAPLL | SCLLALLALC | PGGRPQTVLT | DDEIEEFLEG | FLSELEPEPR |
100:
EDDVEAPPPP | EPTPRVRKAQ | AGGKPGKRPG | TAAEVPPEKT | KDKGKKGKKD |
150:
KGPKVPKESL | EGSPRPPKKG | KEKPPKATKK | PKEKPPKATK | KPKEKPPKAT |
200:
KKPKEKPPKA | TKKPPSGKRP | PILAPSETLE | WPLPPPPSPG | PEELPQEGGA |
250:
PLSNNWQNPG | EETHVEAREH | QPEPEEETEQ | PTLDYNDQIE | REDYEDFEYI |
300:
RRQKQPRPPP | SRRRRPERVW | PEPPEEKAPA | PAPEERIEPP | VKPLLPPLPP |
350:
DYGDGYVIPN | YDDMDYYFGP | PPPQKPDAER | QTDEEKEELK | KPKKEDSSPK |
400:
EETDKWAVEK | GKDHKEPRKG | EELEEEWTPT | EKVKCPPIGM | ESHRIEDNQI |
450:
RASSMLRHGL | GAQRGRLNMQ | TGATEDDYYD | GAWCAEDDAR | TQWIEVDTRR |
500:
TTRFTGVITQ | GRDSSIHDDF | VTTFFVGFSN | DSQTWVMYTN | GYEEMTFHGN |
550:
VDKDTPVLSE | LPEPVVARFI | RIYPLTWNGS | LCMRLEVLGC | SVAPVYSYYA |
600:
QNEVVATDDL | DFRHHSYKDM | RQLMKVVNEE | CPTITRTYSL | GKSSRGLKIY |
650:
AMEISDNPGE | HELGEPEFRY | TAGIHGNEVL | GRELLLLLMQ | YLCREYRDGN |
700:
PRVRSLVQDT | RIHLVPSLNP | DGYEVAAQMG | SEFGNWALGL | WTEEGFDIFE |
750:
DFPDLNSVLW | GAEERKWVPY | RVPNNNLPIP | ERYLSPDATV | STEVRAIIAW |
800:
MEKNPFVLGA | NLNGGERLVS | YPYDMARTPT | QEQLLAAAMA | AARGEDEDEV |
850:
SEAQETPDHA | IFRWLAISFA | SAHLTLTEPY | RGGCQAQDYT | GGMGIVNGAK |
900:
WNPRTGTIND | FSYLHTNCLE | LSFYLGCDKF | PHESELPREW | ENNKEALLTF |
950:
MEQVHRGIKG | VVTDEQGIPI | ANATISVSGI | NHGVKTASGG | DYWRILNPGE |
1000:
YRVTAHAEGY | TPSAKTCNVD | YDIGATQCNF | ILARSNWKRI | REIMAMNGNR |
1050:
PIPHIDPSRP | MTPQQRRLQQ | RRLQHRLRLR | AQMRLRRLNA | TTTLGPHTVP |
1100:
PTLPPAPATT | LSTTIEPWGL | IPPTTAGWEE | SETETYTEVV | TEFGTEVEPE |
1150:
FGTKVEPEFE | TQLEPEFETQ | LEPEFEEEEE | EEKEEEIATG | QAFPFTTVET |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human AE-binding protein 1
ELISA Kit for Human AE-binding protein 1
ELISA Kit for Human AE-binding protein 1
CLIA Kit for Human AE-binding protein 1
CLIA Kit for Human AE-binding protein 1
CLIA Kit for Human AE-binding protein 1
Polyclonal Antibody for Human AE-binding protein 1
Polyclonal Antibody for Human AE-binding protein 1
Polyclonal Antibody for Human AE-binding protein 1
Monoclonal Antibody for Human AE-binding protein 1
Monoclonal Antibody for Human AE-binding protein 1
Monoclonal Antibody for Human AE-binding protein 1
Protein for Human AE-binding protein 1
Protein for Human AE-binding protein 1
Protein for Human AE-binding protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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Aortic smooth muscle .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLU-1133
tissue :
Aortic endothelium .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 314-1158 (ISOFORM 1);TISSUE SPECIFICITY
tissue :
Cancellous bone .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-528 AND ASN-922
tissue :
Liver .