Aebp1 ELISA Kit for Mouse(Mus musculus) | EIAab.comAebp1 ELISA Kit for Mouse(Mus musculus)

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Aebp1 (Gene name),

Adipocyte enhancer-binding protein 1 (Protein name ), AEBP1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Aebp1(Aclp);

Protein name:

Adipocyte enhancer-binding protein 1(AE-binding protein 1);

Alternative:

Aortic carboxypeptidase-like protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Isoform 2 interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN. Interaction with MAPK1 may stimulate DNA-binding. May interact with calmodulin. Binds to DNA in vitro.

Function:

Isoform 2 may positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. Isoform 2 may also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

Subcellular Location:

Isoform 2 Cytoplasm Nucleus

Protein Attributes:

Sequence length:

1128

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1128:

EEEEEEMDTG | LTFPLTTVET | YTVNFGDF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q640N1

KEGG:

mmu:11568

Pfam:

PF00754

String:

Q640N1

UniGene:

Mm.4665

Uniprot:

Q640N1

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ELISA Kit for Mouse AE-binding protein 1

Cat.:

E7716h

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96T

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ELISA Kit for Mouse AE-binding protein 1

Cat.:

E7716r

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Packing:

96T

ELISA Kit for Mouse AE-binding protein 1

Cat.:

E7716m

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96T

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CLIA Kit for Mouse AE-binding protein 1

Cat.:

U7716m

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96T

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CLIA Kit for Mouse AE-binding protein 1

Cat.:

U7716r

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Packing:

96T

CLIA Kit for Mouse AE-binding protein 1

Cat.:

U7716h

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96T

Polyclonal Antibody for Mouse AE-binding protein 1

Cat.:

P7716Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse AE-binding protein 1

Cat.:

P7716Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse AE-binding protein 1

Cat.:

P7716Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse AE-binding protein 1

Protein for Mouse AE-binding protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A eukaryotic transcriptional repressor with carboxypeptidase activity."
He G.-P. , Muise A.M. , Li A.W. , Ro H.-S.
Nature378:92-96(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;DEVELOPMENTAL STAGE
tissue: Embryo.
2.

"Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation."
Layne M.D. , Endege W.O. , Jain M.K. , Yet S.-F. , Hsieh C.-M. , Chin M.T. , Perrella M.A. , Blanar M.A. , Haber E. , Lee M.-E.
J. Biol. Chem.273:15654-15660(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6J.
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6.
tissue: Eye.
6.

"A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line."
Ohno I. , Hashimoto J. , Shimizu K. , Takaoka K. , Ochi T. , Matsubara K. , Okubo K.
Biochem. Biophys. Res. Commun.228:411-414(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
7.

"Transcriptional regulation by the gamma5 subunit of a heterotrimeric G protein during adipogenesis."
Park J.-G. , Muise A.M. , He G.-P. , Kim S.-W. , Ro H.-S.
EMBO J.18:4004-4012(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH GNG5
8.

"Gene structure and expression of the mouse adipocyte enhancer-binding protein."
Ro H.-S. , Kim S.-W. , Wu D. , Webber C. , Nicholson T.E.
Gene280:123-133(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY
9.

"Regulation of adipogenesis by a transcriptional repressor that modulates MAPK activation."
Kim S.-W. , Muise A.M. , Lyons P.J. , Ro H.-S.
J. Biol. Chem.276:10199-10206(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAPK1 AND MAPK3;DEVELOPMENTAL STAGE
10.

"Impaired abdominal wall development and deficient wound healing in mice lacking aortic carboxypeptidase-like protein."
Layne M.D. , Yet S.-F. , Maemura K. , Hsieh C.-M. , Bernfield M. , Perrella M.A. , Lee M.-E.
Mol. Cell. Biol.21:5256-5261(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
11.

"Down-regulation of aortic carboxypeptidase-like protein during the early phase of 3T3-L1 adipogenesis."
Gagnon A. , Abaiian K.J. , Crapper T. , Layne M.D. , Sorisky A.
Endocrinology143:2478-2485(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
12.

"Transdifferentiation of preadipose cells into smooth muscle-like cells: role of aortic carboxypeptidase-like protein."
Abderrahim-Ferkoune A. , Bezy O. , Astri-Roques S. , Elabd C. , Ailhaud G. , Amri E.-Z.
Exp. Cell Res.293:219-228(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
13.

"MAPK modulates the DNA binding of adipocyte enhancer-binding protein 1."
Lyons P.J. , Muise A.M. , Ro H.-S.
Biochemistry44:926-931(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;MUTAGENESIS OF THR-1003;PHOSPHORYLATION
14.

"Aortic carboxypeptidase-like protein is regulated by transforming growth factor beta in 3T3-L1 preadipocytes."
Gagnon A. , Landry A. , Proulx J. , Layne M.D. , Sorisky A.
Exp. Cell Res.308:265-272(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;INDUCTION
15.

"Aortic carboxypeptidase-like protein is expressed in collagen-rich tissues during mouse embryonic development."
Ith B. , Wei J. , Yet S.-F. , Perrella M.A. , Layne M.D.
Gene Expr. Patterns5:533-537(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
16.

"The role of AEBP1 in sex-specific diet-induced obesity."
Zhang L. , Reidy S.P. , Nicholson T.E. , Lee H.-J. , Majdalawieh A. , Webber C. , Stewart B.R. , Dolphin P. , Ro H.-S.
Mol. Med.11:39-47(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
17.

"Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation."
Majdalawieh A. , Zhang L. , Fuki I.V. , Rader D.J. , Ro H.-S.
Proc. Natl. Acad. Sci. U.S.A.103:2346-2351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING
18.

"Modeling and functional analysis of AEBP1, a transcriptional repressor."
Lyons P.J. , Mattatall N.R. , Ro H.-S.
Proteins63:1069-1083(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH CALMODULIN
19.

"Adipocyte enhancer-binding protein-1 promotes macrophage inflammatory responsiveness by up-regulating NF-kappaB via IkappaBalpha negative regulation."
Majdalawieh A. , Zhang L. , Ro H.-S.
Mol. Biol. Cell18:930-942(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NFKBIA;SUBCELLULAR LOCATION
20.

"Adipocyte enhancer-binding protein 1 modulates adiposity and energy homeostasis."
Ro H.-S. , Zhang L. , Majdalawieh A. , Kim S.-W. , Wu X. , Lyons P.J. , Webber C. , Ma H. , Reidy S.P. , Boudreau A. , Miller J.R. , Mitchell P. , McLeod R.S.
Obesity15:288-302(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;INTERACTION WITH PTEN

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