Protein name:
Adipocyte enhancer-binding protein 1 (AE-binding protein 1) ;
Alternative:
Aortic carboxypeptidase-like protein ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with GNG5, NFKBIA, MAPK1, MAPK3 and PTEN (By similarity). May interact with calmodulin (By similarity). Binds to DNA in vitro.
Function:
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation (By similarity). May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness (By similarity). Can act as a transcriptional repressor.
Subcellular Location:
Secreted
Cytoplasm
Nucleus
Protein Attributes:
50:
MAAVRTASLL | CGLLALLALC | PEGSPQTVLT | DDEIQEFLEG | FLSEFETQSP |
100:
PREDDVEAQP | LPEPTQRARK | SKAGGKPRAD | AEAPPEKNKD | KEKKGKKDKG |
150:
PKAAKHLEGS | TRPTKKPKEK | PPKATKKPKE | KPPKATKKPK | EKPPKATKKP |
200:
KEKPPKATKR | PSAGKRFSTV | APLETPERSL | TSPSNPGTRE | LPEERGRTSL |
250:
NTWQGQGEET | QVEARQHRPE | PEEETEMPTL | DYNDQIERED | YEDFEYIRRQ |
300:
KQPRPTPSRK | RIWPEPPEEK | TQEPEERKEV | DPPLKPLLPP | DYGDGYLIPN |
350:
YDDLDYYFPH | PPPQKPDVGQ | EVDEEKEELK | KPKKEGSSPK | EDTEDKWAAE |
400:
KNKDHKAGPR | KGEELEEEWG | PVEKIKCPPI | GMESHRIEDN | QIRASSMLRH |
450:
GLGAQRGRLN | MQAGANEDDY | YDGAWCAEDE | SQTQWIEVDT | RRTTRFTGVI |
500:
TQGRDSSIHD | DFVTTFFVGF | SNDSQTWVMY | TNGYEEMTFH | GNVDKDTPVL |
550:
SELPEPVVAR | FIRIYPLTWN | GSLCMRLEVL | GCPVTPVYSY | YAQNEVVTTD |
600:
SLDFRHHSYK | DMRQLMKVVN | EECPTITRTY | SLGKSSRGLK | IYAMEISDNP |
650:
GEHELGEPEF | RYTAGMHGNE | VLGRELLLLL | MQYLCHEYRD | GNPRVRNLVQ |
700:
DTRIHLVPSL | NPDGYEVAAQ | MGSEFGNWAL | GLWTEEGFDI | FEDFPDLNSV |
750:
LWAAEEKKWV | PYRVPNNNLP | IPERYLSPDA | TVSTEVRAII | SWMEKNPFVL |
800:
GANLNGGERL | VSYPYDMART | PSQEQLLAAA | LAAARGEDED | EVSEAQETPD |
850:
HAIFRWLAIS | FASAHLTMTE | PYRGGCQAQD | YTSGMGIVNG | AKWNPRSGTF |
900:
NDFSYLHTNC | LELSIYLGCD | KFPHESELPR | EWENNKEALL | TFMEQVHRGI |
950:
KGVVTDEQGI | PIANATISVS | GINHGVKTAS | GGDYWRILNP | GEYRVTAHAE |
1000:
GYTSSAKICN | VDYDIGATQC | NFILARSNWK | RIREILAMNG | NRPILRVDPS |
1050:
RPMTPQQRRL | QQRRLRYRLR | MREQMRLRRL | NSTTGPATSP | TPALTLPPSP |
1100:
TPGSTSRLWE | ILPTTAAGWE | ESETETYTEV | VTEFETEYGP | DLEVEELEEE |
1128:
EEEEEEMDTG | LTFPVTTVET | YTVNFGDF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Rat AE-binding protein 1
ELISA Kit for Rat AE-binding protein 1
ELISA Kit for Rat AE-binding protein 1
CLIA Kit for Rat AE-binding protein 1
CLIA Kit for Rat AE-binding protein 1
CLIA Kit for Rat AE-binding protein 1
Polyclonal Antibody for Rat AE-binding protein 1
Polyclonal Antibody for Rat AE-binding protein 1
Polyclonal Antibody for Rat AE-binding protein 1
Monoclonal Antibody for Rat AE-binding protein 1
Monoclonal Antibody for Rat AE-binding protein 1
Monoclonal Antibody for Rat AE-binding protein 1
Protein for Rat AE-binding protein 1
Protein for Rat AE-binding protein 1
Protein for Rat AE-binding protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
2.
"Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation."
Layne M.D.
,
Endege W.O.
,
Jain M.K.
,
Yet S.-F.
,
Hsieh C.-M.
,
Chin M.T.
,
Perrella M.A.
,
Blanar M.A.
,
Haber E.
,
Lee M.-E.
J. Biol. Chem.273:15654-15660(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY