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Index > Protein center > AEN(Gene name) > Human
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  • AEN (Gene name),
  • Apoptosis-enhancing nuclease (Protein name ),  AEN_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    AEN(SBBI58;ISG20L1);
    Protein name:
    Apoptosis-enhancing nuclease;
    Alternative:
    Interferon-stimulated 20 kDa exonuclease-like 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis.
    Subcellular Location:
    Nucleus Nucleus nucleolus Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.
    Protein Attributes:
    Sequence length:
    325
    Sequence:
    50:
    MVPREAPESA | QCLCPSLTIP | NAKDVLRKRH | KRRSRQHQRF | MARKALLQEQ | 
    100:
    GLLSMPPEPG | SSPLPTPFGA | ATATEAASSG | KQCLRAGSGS | APCSRRPAPG | 
    150:
    KASGPLPSKC | VAIDCEMVGT | GPRGRVSELA | RCSIVSYHGN | VLYDKYIRPE | 
    200:
    MPIADYRTRW | SGITRQHMRK | AVPFQVAQKE | ILKLLKGKVV | VGHALHNDFQ | 
    250:
    ALKYVHPRSQ | TRDTTYVPNF | LSEPGLHTRA | RVSLKDLALQ | LLHKKIQVGQ | 
    300:
    HGHSSVEDAT | TAMELYRLVE | VQWEQQEARS | LWTCPEDREP | DSSTDMEQYM | 
    325:
    EDQYWPDDLA | HGSRGGAREA | QDRRN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    String:
    KEGG:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Apoptosis-enhancing nuclease
    ELISA Kit for Human Apoptosis-enhancing nuclease
    ELISA Kit for Human Apoptosis-enhancing nuclease
    CLIA Kit for Human Apoptosis-enhancing nuclease
    CLIA Kit for Human Apoptosis-enhancing nuclease
    CLIA Kit for Human Apoptosis-enhancing nuclease
    Polyclonal Antibody for Human Apoptosis-enhancing nuclease
    Polyclonal Antibody for Human Apoptosis-enhancing nuclease
    Polyclonal Antibody for Human Apoptosis-enhancing nuclease
    Monoclonal Antibody for Human Apoptosis-enhancing nuclease
    Monoclonal Antibody for Human Apoptosis-enhancing nuclease
    Monoclonal Antibody for Human Apoptosis-enhancing nuclease
    Protein for Human Apoptosis-enhancing nuclease
    Protein for Human Apoptosis-enhancing nuclease
    Protein for Human Apoptosis-enhancing nuclease

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    Precision
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    Linearity
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    References
    1. 1.
      Zhang W. , Li N. , Wan T. , Chen T. , Zhang J. , Cao X.
      Submitted (2000-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-140
    2. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ASP-140
    3. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ASP-140
      tissue: Colon.
      tissue: Muscle.
    4. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-325 (ISOFORM 1);VARIANT ASP-140
    5. 6.
      "Identification of a novel ionizing radiation-induced nuclease, AEN, and its functional characterization in apoptosis."
      Lee J.-H. , Koh Y.A. , Cho C.-K. , Lee S.J. , Lee Y.-S. , Bae S.
      Biochem. Biophys. Res. Commun.337:39-47(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;SUBCELLULAR LOCATION
    6. 7.
      "p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis."
      Kawase T. , Ichikawa H. , Ohta T. , Nozaki N. , Tashiro F. , Ohki R. , Taya Y.
      Oncogene27:3797-3810(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INDUCTION;NUCLEAR LOCALIZATION SIGNAL;NUCLEOLAR LOCALIZATION SIGNAL;MUTAGENESIS OF ASP-114; GLU-116 AND ASP-258
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