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Index > Protein center > AFAP1L2(Gene name) > Human
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  • AFAP1L2 (Gene name),
  • Actin filament-associated protein 1-like 2 (Protein name ),  AF1L2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AFAP1L2(KIAA1914;XB130);
    Protein name:
    Actin filament-associated protein 1-like 2(AFAP1-like protein 2);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SRC. Interacts with LCK when tyrosine phosphorylated.
    Function:
    May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    818
    Sequence:
    50:
    MERYKALEQL | LTELDDFLKI | LDQENLSSTA | LVKKSCLAEL | LRLYTKSSSS | 
    100:
    DEEYIYMNKV | TINKQQNAES | QGKAPEEQGL | LPNGEPSQHS | SAPQKSLPDL | 
    150:
    PPPKMIPERK | QLAIPKTESP | EGYYEEAEPY | DTSLNEDGEA | VSSSYESYDE | 
    200:
    EDGSKGKSAP | YQWPSPEAGI | ELMRDARICA | FLWRKKWLGQ | WAKQLCVIKD | 
    250:
    NRLLCYKSSK | DHSPQLDVNL | LGSSVIHKEK | QVRKKEHKLK | ITPMNADVIV | 
    300:
    LGLQSKDQAE | QWLRVIQEVS | GLPSEGASEG | NQYTPDAQRF | NCQKPDIAEK | 
    350:
    YLSASEYGSS | VDGHPEVPET | KDVKKKCSAG | LKLSNLMNLG | RKKSTSLEPV | 
    400:
    ERSLETSSYL | NVLVNSQWKS | RWCSVRDNHL | HFYQDRNRSK | VAQQPLSLVG | 
    450:
    CEVVPDPSPD | HLYSFRILHK | GEELAKLEAK | SSEEMGHWLG | LLLSESGSKT | 
    500:
    DPEEFTYDYV | DADRVSCIVS | AAKNSLLLMQ | RKFSEPNTYI | DGLPSQDRQE | 
    550:
    ELYDDVDLSE | LTAAVEPTEE | ATPVADDPNE | RESDRVYLDL | TPVKSFLHGP | 
    600:
    SSAQAQASSP | TLSCLDNATE | ALPADSGPGP | TPDEPCIKCP | ENLGEQQLES | 
    650:
    LEPEDPSLRI | TTVKIQTEQQ | RISFPPSCPD | AVVATPPGAS | PPVKDRLRVT | 
    700:
    SAEIKLGKNR | TEAEVKRYTE | EKERLEKKKE | EIRGHLAQLR | KEKRELKETL | 
    750:
    LKCTDKEVLA | SLEQKLKEID | EECRGEESRR | VDLELSIMEV | KDNLKKAEAG | 
    800:
    PVTLGTTVDT | THLENVSPRP | KAVTPASAPD | CTPVNSATTL | KNRPLSVVVT | 
    818:
    GKGTVLQKAK | EWEKKGAS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    MIM:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human AFAP1-like protein 2
    ELISA Kit for Human AFAP1-like protein 2
    ELISA Kit for Human AFAP1-like protein 2
    CLIA Kit for Human AFAP1-like protein 2
    CLIA Kit for Human AFAP1-like protein 2
    CLIA Kit for Human AFAP1-like protein 2
    Polyclonal Antibody for Human AFAP1-like protein 2
    Polyclonal Antibody for Human AFAP1-like protein 2
    Polyclonal Antibody for Human AFAP1-like protein 2
    Monoclonal Antibody for Human AFAP1-like protein 2
    Monoclonal Antibody for Human AFAP1-like protein 2
    Monoclonal Antibody for Human AFAP1-like protein 2
    Protein for Human AFAP1-like protein 2
    Protein for Human AFAP1-like protein 2
    Protein for Human AFAP1-like protein 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "XB130, a novel adaptor protein for Src binding and activation."
      Bai X.-H. , Keshavjee S. , Liu M.
      Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T. , Kikuno R. , Ohara O.
      DNA Res.8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
      tissue: Cerebellum.
      tissue: Placenta.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Pancreas.
    6. 6.
      "XB130, a novel adaptor protein for signal transduction."
      Xu J. , Bai X.-H. , Lodyga M. , Han B. , Xiao H. , Keshavjee S. , Hu J. , Zhang H. , Yang B.B. , Liu M.
      J. Biol. Chem.282:16401-16412(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SRC;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF TYR-4;PHOSPHORYLATION
    7. 7.
      "Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells."
      Emaduddin M. , Edelmann M.J. , Kessler B.M. , Feller S.M.
      Cell Commun. Signal.6:7-7(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH LCK;IDENTIFICATION BY MASS SPECTROMETRY
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Solution structure of the C-terminal PH domain of hypothetical protein KIAA1914 from human."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 354-448
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