Protein name:
Afadin ;
Alternative:
Protein Af-6 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Interacts with F-actin, nectin and PVRL3/nectin-3. Essential for the association of nectin and E-cadherin. Isoform 2/s-afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in an indirect manner. Interacts with RIT1, RIT2, NRXN1 and BCR.
Function:
Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm.
Subcellular Location:
Cell junction
adherens junction
Not found at cell-matrix AJs.
Protein Attributes:
50:
MSAGGRDEER | RKLADIIHHW | NANRLDLFEI | SQPTEDLEFH | GVMRFYFQDK |
100:
AAGNFATKCI | RVSSTATTQD | VIETLAEKFR | PDMRMLSSPK | YSLYEVHVSG |
150:
ERRLDIDEKP | LVVQLNWNKD | DREGRFVLKN | ENDAIPAKKA | QSNGPEKQEK |
200:
EGVIQNFKRT | LSKKEKKEKK | KKEKEALRQA | SDKEERPSQG | DDSENSRLAA |
250:
EVYKDMPETS | FTRTISNPEV | VMKRRRQQKL | EKRMQEFRSS | DGRPDSGGTL |
300:
RIYADSLKPN | IPYKTILLST | TDTADFAVAE | SLEKYGLEKE | NPKDYCIARV |
350:
MLPPGAQHSD | ERGAKEIILD | DDECPLQIFR | EWPSDKGILV | FQLKRRPPDY |
400:
IPKKMKKHVE | GKSLKGKDRA | DGSGYGSALP | PEKLPYLVEL | SPGRRNHFAY |
450:
YSYHTYEDGS | DSRDKPKLYR | LQLSVTEVGT | EKFDDNSIQL | FGPGIQPHHC |
500:
DLTNMDGVVT | VTPRSMDAET | YVDGQRISET | TMLQSGMRLQ | FGTSHVFKFV |
550:
DPIQDHVLSK | RSVDGGLMVK | GPRHKPGAVQ | ETTFELGGDV | HSGTALPASR |
600:
STTRLDSDRV | SSASSTAERG | MVKPMIRLDQ | EQEYRRRENR | TQDATGPELI |
650:
LPASIEFRES | SEDSFLSAII | NYTNSSTVHF | KLSPTYVLYM | ACRYVLSSQH |
700:
RPDISPTERT | HKAIAVVNKM | VSMMEGVIQK | QKNIAGALAF | WMANASELLN |
750:
FIKQDRDLSR | ITLDAQDVLA | HLVQMAFKYL | VHCLQSELNN | YMPAFLDDPE |
800:
ENSLQRPKID | DVLHTLTGAM | SLLRRCRVNA | ALTIQLFSQL | FHFINMWLFN |
850:
RLVTDPDSGL | CSHYWGAIIR | QQLGHIEAWA | EKQGLELAAD | CHLSRIVQAT |
900:
TLLTMDKYVP | DDIPNINSTC | FKLNSLQLQA | LLQNYHCAPD | EPFIPTDLIE |
950:
NVVAVAENTA | DELARSDGRD | VQLEEDPDLQ | LPFLLPEDGY | SCDVVRNIPN |
1000:
GLQEFLDPLC | QRGFCRLVPH | TRSPGTWTIY | FEGADYESHL | MRENAELAQP |
1050:
LRKEPEIITV | TLKKQNGMGL | SIVAAKGAGQ | DKLGIYVKSV | VKGGAADVDG |
1100:
RLAAGDQLLS | VDGRSLVGLS | QERAAELMTR | TSSVVTLEVA | KQGAIYHGLA |
1150:
TLLNQPSPMM | QRISDRRGSG | KPRPKSEGFE | LYNNSAQNGS | PESPQMPWTE |
1200:
YSEPKKLPGD | DRLMKNRADH | RSSPNVANQP | PSPGGKGPYT | SGTAAKITSV |
1250:
STGNLCTEEQ | SPPPRPEAYP | IPTQTYTREY | FTFPASKSQD | RMAPPQSQWP |
1300:
NYEEKPHVHT | ESNHSSIAIQ | RVTRSQEELR | EEKVYQLERH | RVEAGMDRKC |
1350:
DSDMWINQSS | SVESSTSSQE | HLNHSSKSVT | PASTLTKSGP | GRWKTPAAVL |
1400:
PTPVAVSQPI | RTDLPPPPPP | PPVHYTSEFD | GIPMDLPLPP | PPANQAGPQS |
1450:
AQVAAAEWKK | REEHQRWYEK | EKARLEEERE | RKRREQERKL | GQMRSQTLNP |
1500:
ASFSPLATQA | KPEKPSTLQR | PQETVIRELQ | PQQQPRTIER | KDLQYITISK |
1550:
EELSSGDSLS | PDPWKRDARE | KLEKQQQMHI | VDMLSKEIHE | LQNKVDRTAE |
1600:
ESDRLRKLML | EWQFQKRLQE | SKQKDEDDDE | EEDDDVDTML | IMQRLEAERR |
1650:
ARMQDEERRR | QQQLEEMRKR | EAEDRVRQEE | DGRHQEEERV | KRDAEEKRRQ |
1700:
EEGYYSRLEA | ERRRQHEEAA | RRLLEPEEPG | LSRPPLPRDY | EPPSLSSAPC |
1750:
APPPPPQRNA | SYLKTQVLSP | DSLFTAKFVA | YDEEEEDYGP | AGPNSYSGSA |
1800:
GTAVGAYDAP | REAREKLTRS | QDADLPGSSG | APENLTFKER | QRLFSQGQDV |
1820:
SDKVKASRKL | TELENELNTK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Mouse Afadin
ELISA Kit for Mouse Afadin
ELISA Kit for Mouse Afadin
CLIA Kit for Mouse Afadin
CLIA Kit for Mouse Afadin
CLIA Kit for Mouse Afadin
Polyclonal Antibody for Mouse Afadin
Polyclonal Antibody for Mouse Afadin
Polyclonal Antibody for Mouse Afadin
Monoclonal Antibody for Mouse Afadin
Monoclonal Antibody for Mouse Afadin
Monoclonal Antibody for Mouse Afadin
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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C57BL/6J .
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C57BL/6 .
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-900 (ISOFORM 3)
tissue :
Leukemia .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PVRL3
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107 AND SER-1182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Embryonic fibroblast .
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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