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Index > Protein center > Mllt4(Gene name) > Mouse
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  • Mllt4 (Gene name),
  • Afadin (Protein name ),  AFAD_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Mllt4(Af6);
    Protein name:
    Afadin;
    Alternative:
    Protein Af-6;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with F-actin, nectin and PVRL3/nectin-3. Essential for the association of nectin and E-cadherin. Isoform 2/s-afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in an indirect manner. Interacts with RIT1, RIT2, NRXN1 and BCR.
    Function:
    Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm.
    Subcellular Location:
    Cell junction adherens junction Not found at cell-matrix AJs.
    Protein Attributes:
    Sequence length:
    1820
    Sequence:
    50:
    MSAGGRDEER | RKLADIIHHW | NANRLDLFEI | SQPTEDLEFH | GVMRFYFQDK | 
    100:
    AAGNFATKCI | RVSSTATTQD | VIETLAEKFR | PDMRMLSSPK | YSLYEVHVSG | 
    150:
    ERRLDIDEKP | LVVQLNWNKD | DREGRFVLKN | ENDAIPAKKA | QSNGPEKQEK | 
    200:
    EGVIQNFKRT | LSKKEKKEKK | KKEKEALRQA | SDKEERPSQG | DDSENSRLAA | 
    250:
    EVYKDMPETS | FTRTISNPEV | VMKRRRQQKL | EKRMQEFRSS | DGRPDSGGTL | 
    300:
    RIYADSLKPN | IPYKTILLST | TDTADFAVAE | SLEKYGLEKE | NPKDYCIARV | 
    350:
    MLPPGAQHSD | ERGAKEIILD | DDECPLQIFR | EWPSDKGILV | FQLKRRPPDY | 
    400:
    IPKKMKKHVE | GKSLKGKDRA | DGSGYGSALP | PEKLPYLVEL | SPGRRNHFAY | 
    450:
    YSYHTYEDGS | DSRDKPKLYR | LQLSVTEVGT | EKFDDNSIQL | FGPGIQPHHC | 
    500:
    DLTNMDGVVT | VTPRSMDAET | YVDGQRISET | TMLQSGMRLQ | FGTSHVFKFV | 
    550:
    DPIQDHVLSK | RSVDGGLMVK | GPRHKPGAVQ | ETTFELGGDV | HSGTALPASR | 
    600:
    STTRLDSDRV | SSASSTAERG | MVKPMIRLDQ | EQEYRRRENR | TQDATGPELI | 
    650:
    LPASIEFRES | SEDSFLSAII | NYTNSSTVHF | KLSPTYVLYM | ACRYVLSSQH | 
    700:
    RPDISPTERT | HKAIAVVNKM | VSMMEGVIQK | QKNIAGALAF | WMANASELLN | 
    750:
    FIKQDRDLSR | ITLDAQDVLA | HLVQMAFKYL | VHCLQSELNN | YMPAFLDDPE | 
    800:
    ENSLQRPKID | DVLHTLTGAM | SLLRRCRVNA | ALTIQLFSQL | FHFINMWLFN | 
    850:
    RLVTDPDSGL | CSHYWGAIIR | QQLGHIEAWA | EKQGLELAAD | CHLSRIVQAT | 
    900:
    TLLTMDKYVP | DDIPNINSTC | FKLNSLQLQA | LLQNYHCAPD | EPFIPTDLIE | 
    950:
    NVVAVAENTA | DELARSDGRD | VQLEEDPDLQ | LPFLLPEDGY | SCDVVRNIPN | 
    1000:
    GLQEFLDPLC | QRGFCRLVPH | TRSPGTWTIY | FEGADYESHL | MRENAELAQP | 
    1050:
    LRKEPEIITV | TLKKQNGMGL | SIVAAKGAGQ | DKLGIYVKSV | VKGGAADVDG | 
    1100:
    RLAAGDQLLS | VDGRSLVGLS | QERAAELMTR | TSSVVTLEVA | KQGAIYHGLA | 
    1150:
    TLLNQPSPMM | QRISDRRGSG | KPRPKSEGFE | LYNNSAQNGS | PESPQMPWTE | 
    1200:
    YSEPKKLPGD | DRLMKNRADH | RSSPNVANQP | PSPGGKGPYT | SGTAAKITSV | 
    1250:
    STGNLCTEEQ | SPPPRPEAYP | IPTQTYTREY | FTFPASKSQD | RMAPPQSQWP | 
    1300:
    NYEEKPHVHT | ESNHSSIAIQ | RVTRSQEELR | EEKVYQLERH | RVEAGMDRKC | 
    1350:
    DSDMWINQSS | SVESSTSSQE | HLNHSSKSVT | PASTLTKSGP | GRWKTPAAVL | 
    1400:
    PTPVAVSQPI | RTDLPPPPPP | PPVHYTSEFD | GIPMDLPLPP | PPANQAGPQS | 
    1450:
    AQVAAAEWKK | REEHQRWYEK | EKARLEEERE | RKRREQERKL | GQMRSQTLNP | 
    1500:
    ASFSPLATQA | KPEKPSTLQR | PQETVIRELQ | PQQQPRTIER | KDLQYITISK | 
    1550:
    EELSSGDSLS | PDPWKRDARE | KLEKQQQMHI | VDMLSKEIHE | LQNKVDRTAE | 
    1600:
    ESDRLRKLML | EWQFQKRLQE | SKQKDEDDDE | EEDDDVDTML | IMQRLEAERR | 
    1650:
    ARMQDEERRR | QQQLEEMRKR | EAEDRVRQEE | DGRHQEEERV | KRDAEEKRRQ | 
    1700:
    EEGYYSRLEA | ERRRQHEEAA | RRLLEPEEPG | LSRPPLPRDY | EPPSLSSAPC | 
    1750:
    APPPPPQRNA | SYLKTQVLSP | DSLFTAKFVA | YDEEEEDYGP | AGPNSYSGSA | 
    1800:
    GTAVGAYDAP | REAREKLTRS | QDADLPGSSG | APENLTFKER | QRLFSQGQDV | 
    1820:
    SDKVKASRKL | TELENELNTK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Afadin
    ELISA Kit for Mouse Afadin
    ELISA Kit for Mouse Afadin
    CLIA Kit for Mouse Afadin
    CLIA Kit for Mouse Afadin
    CLIA Kit for Mouse Afadin
    Polyclonal Antibody for Mouse Afadin
    Polyclonal Antibody for Mouse Afadin
    Polyclonal Antibody for Mouse Afadin
    Monoclonal Antibody for Mouse Afadin
    Monoclonal Antibody for Mouse Afadin
    Monoclonal Antibody for Mouse Afadin
    Protein for Mouse Afadin
    Protein for Mouse Afadin
    Protein for Mouse Afadin

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      "Afadin: a key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis."
      Ikeda W. , Nakanishi H. , Miyoshi J. , Mandai K. , Ishizaki H. , Tanaka M. , Togawa A. , Takahashi K. , Nishioka H. , Yoshida H. , Mizoguchi A. , Nishikawa S. , Takai Y.
      J. Cell Biol.146:1117-1132(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-320 (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
      strain: C57BL/6.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-900 (ISOFORM 3)
      tissue: Leukemia.
    4. 4.
      "Nectin-3: a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities."
      Satoh-Horikawa K. , Nakanishi H. , Takahashi K. , Miyahara M. , Nishimura M. , Tachibana K. , Mizoguchi A. , Takai Y.
      J. Biol. Chem.275:10291-10299(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PVRL3
    5. 5.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    7. 7.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107 AND SER-1182;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    9. 9.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1803;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    10. 10.
      "Solution structure of the FHA domain and RAS-binding domain in mouse AF-6 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-07) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 246-487
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