Mllt4 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comMllt4 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Mllt4(Gene name) > Rat

Mllt4 (Gene name),

Afadin (Protein name ), AFAD_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Mllt4(Af6);

Protein name:

Afadin;

Alternative:

Protein Af-6;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer. Interacts with F-actin, nectin and PVRL3/nectin-3. Essential for the association of nectin and E-cadherin. Isoform 2/s-afadin does not interact with F-actin. Interacts with ZO-1 and occludin, but probably in an indirect manner. Interacts with RIT1, RIT2, NRXN1 and BCR.

Function:

Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm.

Subcellular Location:

Cell junction adherens junction Not found at cell-matrix AJs.

Protein Attributes:

Sequence length:

1829

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1829:

RLFSQGQDVS | DKVKASRKLT | ELENELNTK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O35889

STRING:

10116.ENSRNOP00000029044

KEGG:

rno:26955

Pfam:

PF01843

SMR:

O35889

UniGene:

Rn.58

Uniprot:

O35889

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ELISA Kit for Rat Afadin

CLIA Kit for Rat Afadin

Polyclonal Antibody for Rat Afadin

Monoclonal Antibody for Rat Afadin

Protein for Rat Afadin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Afadin: a novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction."
Mandai K. , Nakanishi H. , Satoh A. , Obaishi H. , Wada M. , Nishioka H. , Itoh M. , Mizoguchi A. , Aoki T. , Fujimoto T. , Matsuda Y. , Tsukita S. , Takai Y.
J. Cell Biol.139:517-528(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);PARTIAL PROTEIN SEQUENCE;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH F-ACTIN
tissue: Brain.

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