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AGAP2 (Gene name),

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (Protein name ), AGAP2_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

AGAP2(CENTG1;KIAA0167);

Protein name:

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2(AGAP-2);

Alternative:

GTP-binding and GTPase-activating protein 2(GGAP2);Centaurin-gamma-1(Cnt-g1);Phosphatidylinositol-3-kinase enhancer(PIKE);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex.

Function:

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Subcellular Location:

Isoform 2 Cytoplasm

Protein Attributes:

Sequence length:

1192

Sequence:

50:

MSRGAGALQR | RTTTYLISLT | LVKLESVPPP | PPSPSAAAVG | APGARGSEPR |

100:

DPGSPRGAEE | PGKKRHERLF | HRQDALWIST | SSAGAGGAEP | PALSPAPASP |

150:

ARPVSPAPGR | RLSLWAAPPG | PPLSGGLSPD | SKPGGAPSSS | RRPLLSSPSW |

200:

GGPEPEGRTG | GGVPGSSSPH | PGTGSRRLKV | APPPPAPKPC | KTVTTSGAKA |

250:

GGGKGAGSRL | SWPESEGKPR | VKGSKSSAGT | GASVSAAATA | AAAGGGGSTA |

300:

STSGGVGAGA | GARGKLSPRK | GKSKTLDNSD | LHPGPPAGSP | PPLTLPPTPS |

350:

PATAVTAASA | QPPGPAPPIT | LEPPAPGLKR | GREGGRASTR | DRKMLKFISG |

400:

IFTKSTGGPP | GSGPLPGPPS | LSSGSGSREL | LGAELRASPK | AVINSQEWTL |

450:

SRSIPELRLG | VLGDARSGKS | SLIHRFLTGS | YQVLEKTESE | QYKKEMLVDG |

500:

QTHLVLIREE | AGAPDAKFSG | WADAVIFVFS | LEDENSFQAV | SRLHGQLSSL |

550:

RGEGRGGLAL | ALVGTQDRIS | ASSPRVVGDA | RARALCADMK | RCSYYETCAT |

600:

YGLNVDRVFQ | EVAQKVVTLR | KQQQLLAACK | SLPSSPSHSA | ASTPVAGQAS |

650:

NGGHTSDYSS | SLPSSPNVGH | RELRAEAAAV | AGLSTPGSLH | RAAKRRTSLF |

700:

ANRRGSDSEK | RSLDSRGETT | GSGRAIPIKQ | SFLLKRSGNS | LNKEWKKKYV |

750:

TLSSNGFLLY | HPSINDYIHS | THGKEMDLLR | TTVKVPGKRP | PRAISAFGPS |

800:

ASINGLVKDM | STVQMGEGLE | ATTPMPSPSP | SPSSLQPPPD | QTSKHLLKPD |

850:

RNLARALSTD | CTPSGDLSPL | SREPPPSPMV | KKQRRKKLTT | PSKTEGSAGQ |

900:

AEAKRKMWKL | KSFGSLRNIY | KAEENFEFLI | VSSTGQTWHF | EAASFEERDA |

950:

WVQAIESQIL | ASLQCCESSK | VKLRTDSQSE | AVAIQAIRNA | KGNSICVDCG |

1000:

APNPTWASLN | LGALICIECS | GIHRNLGTHL | SRVRSLDLDD | WPRELTLVLT |

1050:

AIGNDTANRV | WESDTRGRAK | PSRDSSREER | ESWIRAKYEQ | LLFLAPLSTS |

1100:

EEPLGRQLWA | AVQAQDVATV | LLLLAHARHG | PLDTSVEDPQ | LRSPLHLAAE |

1150:

LAHVVITQLL | LWYGADVAAR | DAQGRTALFY | ARQAGSQLCA | DILLQHGCPG |

1192:

EGGSAATTPS | AATTPSITAT | PSPRRRSSAA | SVGRADAPVA | LV

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

MIM:

UniGene:

SMR:

Pfam:

STRING:

9606.ENSP00000328160

KEGG:

String:

Uniprot:

FOR

ELISA Kit for Human AGAP-2

ELISA Kit for Human AGAP-2

ELISA Kit for Human AGAP-2

CLIA Kit for Human AGAP-2

CLIA Kit for Human AGAP-2

CLIA Kit for Human AGAP-2

Polyclonal Antibody for Human AGAP-2

Polyclonal Antibody for Human AGAP-2

Polyclonal Antibody for Human AGAP-2

Monoclonal Antibody for Human AGAP-2

Monoclonal Antibody for Human AGAP-2

Monoclonal Antibody for Human AGAP-2

Protein for Human AGAP-2

Protein for Human AGAP-2

Protein for Human AGAP-2

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

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"Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers."
Elkahloun A.G. , Krizman D.B. , Wang Z. , Hofmann T.A. , Roe B.A. , Meltzer P.S.
Genomics42:295-301(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 2);VARIANT VAL-1124
2.

Roe B.
Submitted (2002-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 389; 768-769; 1124; 1137 AND 1147 (ISOFORM 2)
3.

"GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins."
Xia C. , Ma W. , Stafford L.J. , Liu C. , Gong L. , Martin J.F. , Liu M.
Mol. Cell. Biol.23:2476-2488(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;FUNCTION
tissue: Heart.
4.

"PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis."
Rong R. , Ahn J.-Y. , Huang H. , Nagata E. , Kalman D. , Kapp J.A. , Tu J. , Worley P.F. , Snyder S.H. , Ye K.
Nat. Neurosci.6:1153-1161(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

"Kiaa0167 as a member (centaurin gamma1) of centaurin ArfGAP family."
Hong W.
Submitted (2001-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
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Nagase T. , Seki N. , Ishikawa K. , Tanaka A. , Nomura N.
DNA Res.3:17-24(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Bone marrow.
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Thymus.
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Blood.
10.

"PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion."
Ahn J.-Y. , Rong R. , Kroll T.G. , Van Meir E.G. , Snyder S.H. , Ye K.
J. Biol. Chem.279:16441-16451(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH AKT1;FUNCTION
11.

"PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt."
Ahn J.-Y. , Hu Y. , Kroll T.G. , Allard P. , Ye K.
Proc. Natl. Acad. Sci. U.S.A.101:6993-6998(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH AKT1;FUNCTION
12.

"The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3."
Nie Z. , Fei J. , Premont R.T. , Randazzo P.A.
J. Cell Sci.118:3555-3566(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INTERACTION WITH THE AP-1 COMPLEX;FUNCTION
13.

"Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas."
Knobbe C.B. , Trampe-Kieslich A. , Reifenberger G.
Neuropathol. Appl. Neurobiol.31:486-490(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
14.

"Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival."
Tang X. , Feng Y. , Ye K.
Cell Death Differ.14:368-377(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-682 AND TYR-774 (ISOFORM 2) BY FYN
15.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-638;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
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"The centaurin gamma-1 GTPase-like domain functions as an NTPase."
Soundararajan M. , Yang X. , Elkins J.M. , Sobott F. , Doyle D.A.
Biochem. J.401:679-688(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 402-577
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"Split pleckstrin homology domain-mediated cytoplasmic-nuclear localization of PI3-kinase enhancer GTPase."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 674-914
18.

"Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings."
Hu Y. , Liu Z. , Ye K.
Proc. Natl. Acad. Sci. U.S.A.102:16853-16858(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-455; GLY-518; ILE-568; VAL-651; VAL-767; ASP-939; MET-947 AND PRO-1022;SUBCELLULAR LOCATION
19.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-339 AND TYR-816

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