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Index > Protein center > EIF2C4(Gene name) > Human
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  • EIF2C4 (Gene name),
  • Protein argonaute-4 (Protein name ),  AGO4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EIF2C4(AGO4;KIAA1567);
    Protein name:
    Protein argonaute-4(Argonaute4;hAgo4);
    Alternative:
    Eukaryotic translation initiation factor 2C 4(eIF-2C 4);Eukaryotic translation initiation factor 2C 4(eIF-2C 4;eIF2C 4);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B.
    Function:
    Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).
    Subcellular Location:
    Cytoplasm P-body
    Protein Attributes:
    Sequence length:
    861
    Sequence:
    50:
    MEALGPGPPA | SLFQPPRRPG | LGTVGKPIRL | LANHFQVQIP | KIDVYHYDVD | 
    100:
    IKPEKRPRRV | NREVVDTMVR | HFKMQIFGDR | QPGYDGKRNM | YTAHPLPIGR | 
    150:
    DRVDMEVTLP | GEGKDQTFKV | SVQWVSVVSL | QLLLEALAGH | LNEVPDDSVQ | 
    200:
    ALDVITRHLP | SMRYTPVGRS | FFSPPEGYYH | PLGGGREVWF | GFHQSVRPAM | 
    250:
    WNMMLNIDVS | ATAFYRAQPI | IEFMCEVLDI | QNINEQTKPL | TDSQRVKFTK | 
    300:
    EIRGLKVEVT | HCGQMKRKYR | VCNVTRRPAS | HQTFPLQLEN | GQAMECTVAQ | 
    350:
    YFKQKYSLQL | KYPHLPCLQV | GQEQKHTYLP | LEVCNIVAGQ | RCIKKLTDNQ | 
    400:
    TSTMIKATAR | SAPDRQEEIS | RLVKSNSMVG | GPDPYLKEFG | IVVHNEMTEL | 
    450:
    TGRVLPAPML | QYGGRNKTVA | TPNQGVWDMR | GKQFYAGIEI | KVWAVACFAP | 
    500:
    QKQCREDLLK | SFTDQLRKIS | KDAGMPIQGQ | PCFCKYAQGA | DSVEPMFKHL | 
    550:
    KMTYVGLQLI | VVILPGKTPV | YAEVKRVGDT | LLGMATQCVQ | VKNVVKTSPQ | 
    600:
    TLSNLCLKIN | AKLGGINNVL | VPHQRPSVFQ | QPVIFLGADV | THPPAGDGKK | 
    650:
    PSIAAVVGSM | DGHPSRYCAT | VRVQTSRQEI | SQELLYSQEV | IQDLTNMVRE | 
    700:
    LLIQFYKSTR | FKPTRIIYYR | GGVSEGQMKQ | VAWPELIAIR | KACISLEEDY | 
    750:
    RPGITYIVVQ | KRHHTRLFCA | DKTERVGKSG | NVPAGTTVDS | TITHPSEFDF | 
    800:
    YLCSHAGIQG | TSRPSHYQVL | WDDNCFTADE | LQLLTYQLCH | TYVRCTRSVS | 
    850:
    IPAPAYYARL | VAFRARYHLV | DKDHDSAEGS | HVSGQSNGRD | PQALAKAVQI | 
    861:
    HHDTQHTMYF | A
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    Pfam:
    SMR:
    UniGene:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Argonaute4
    ELISA Kit for Human Argonaute4
    ELISA Kit for Human Argonaute4
    CLIA Kit for Human Argonaute4
    CLIA Kit for Human Argonaute4
    CLIA Kit for Human Argonaute4
    Polyclonal Antibody for Human Argonaute4
    Polyclonal Antibody for Human Argonaute4
    Polyclonal Antibody for Human Argonaute4
    Monoclonal Antibody for Human Argonaute4
    Monoclonal Antibody for Human Argonaute4
    Monoclonal Antibody for Human Argonaute4
    Protein for Human Argonaute4
    Protein for Human Argonaute4
    Protein for Human Argonaute4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Nakayama M. , Hirosawa M. , Ohara O.
      DNA Res.7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    2. 2.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs."
      Meister G. , Landthaler M. , Patkaniowska A. , Dorsett Y. , Teng G. , Tuschl T.
      Mol. Cell15:185-197(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH MIRNA
    6. 6.
      "Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis."
      Pillai R.S. , Artus C.G. , Filipowicz W.
      RNA10:1518-1525(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Inhibition of translational initiation by Let-7 MicroRNA in human cells."
      Pillai R.S. , Bhattacharyya S.N. , Artus C.G. , Zoller T. , Cougot N. , Basyuk E. , Bertrand E. , Filipowicz W.
      Science309:1573-1576(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    8. 8.
      "Importance of translation and nonnucleolytic ago proteins for on-target RNA interference."
      Wu L. , Fan J. , Belasco J.G.
      Curr. Biol.18:1327-1332(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Capped small RNAs and MOV10 in human hepatitis delta virus replication."
      Haussecker D. , Cao D. , Huang Y. , Parameswaran P. , Fire A.Z. , Kay M.A.
      Nat. Struct. Mol. Biol.15:714-721(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs."
      Weinmann L. , Hoeck J. , Ivacevic T. , Ohrt T. , Muetze J. , Schwille P. , Kremmer E. , Benes V. , Urlaub H. , Meister G.
      Cell136:496-507(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF4B; IMP8; PRMT5; TNRC6A AND TNRC6B;SUBCELLULAR LOCATION
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