Gene name:
EIF2C4 (AGO4;KIAA1567) ;
Protein name:
Protein argonaute-4 (Argonaute4;hAgo4) ;
Alternative:
Eukaryotic translation initiation factor 2C 4 (eIF-2C 4) ;Eukaryotic translation initiation factor 2C 4 (eIF-2C 4;eIF2C 4) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with EIF4B, IMP8, PRMT5, TNRC6A and TNRC6B.
Function:
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV).
Subcellular Location:
Cytoplasm
P-body
Protein Attributes:
50:
MEALGPGPPA | SLFQPPRRPG | LGTVGKPIRL | LANHFQVQIP | KIDVYHYDVD |
100:
IKPEKRPRRV | NREVVDTMVR | HFKMQIFGDR | QPGYDGKRNM | YTAHPLPIGR |
150:
DRVDMEVTLP | GEGKDQTFKV | SVQWVSVVSL | QLLLEALAGH | LNEVPDDSVQ |
200:
ALDVITRHLP | SMRYTPVGRS | FFSPPEGYYH | PLGGGREVWF | GFHQSVRPAM |
250:
WNMMLNIDVS | ATAFYRAQPI | IEFMCEVLDI | QNINEQTKPL | TDSQRVKFTK |
300:
EIRGLKVEVT | HCGQMKRKYR | VCNVTRRPAS | HQTFPLQLEN | GQAMECTVAQ |
350:
YFKQKYSLQL | KYPHLPCLQV | GQEQKHTYLP | LEVCNIVAGQ | RCIKKLTDNQ |
400:
TSTMIKATAR | SAPDRQEEIS | RLVKSNSMVG | GPDPYLKEFG | IVVHNEMTEL |
450:
TGRVLPAPML | QYGGRNKTVA | TPNQGVWDMR | GKQFYAGIEI | KVWAVACFAP |
500:
QKQCREDLLK | SFTDQLRKIS | KDAGMPIQGQ | PCFCKYAQGA | DSVEPMFKHL |
550:
KMTYVGLQLI | VVILPGKTPV | YAEVKRVGDT | LLGMATQCVQ | VKNVVKTSPQ |
600:
TLSNLCLKIN | AKLGGINNVL | VPHQRPSVFQ | QPVIFLGADV | THPPAGDGKK |
650:
PSIAAVVGSM | DGHPSRYCAT | VRVQTSRQEI | SQELLYSQEV | IQDLTNMVRE |
700:
LLIQFYKSTR | FKPTRIIYYR | GGVSEGQMKQ | VAWPELIAIR | KACISLEEDY |
750:
RPGITYIVVQ | KRHHTRLFCA | DKTERVGKSG | NVPAGTTVDS | TITHPSEFDF |
800:
YLCSHAGIQG | TSRPSHYQVL | WDDNCFTADE | LQLLTYQLCH | TYVRCTRSVS |
850:
IPAPAYYARL | VAFRARYHLV | DKDHDSAEGS | HVSGQSNGRD | PQALAKAVQI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
ELISA Kit for Human Argonaute4
ELISA Kit for Human Argonaute4
ELISA Kit for Human Argonaute4
CLIA Kit for Human Argonaute4
CLIA Kit for Human Argonaute4
CLIA Kit for Human Argonaute4
Polyclonal Antibody for Human Argonaute4
Polyclonal Antibody for Human Argonaute4
Polyclonal Antibody for Human Argonaute4
Monoclonal Antibody for Human Argonaute4
Monoclonal Antibody for Human Argonaute4
Monoclonal Antibody for Human Argonaute4
Protein for Human Argonaute4
Protein for Human Argonaute4
Protein for Human Argonaute4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.
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Cited for : ASSOCIATION WITH MIRNA
6.
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Cited for : FUNCTION
7.
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Cited for : SUBCELLULAR LOCATION
8.
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Cited for : FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH EIF4B; IMP8; PRMT5; TNRC6A AND TNRC6B;SUBCELLULAR LOCATION