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Index > Protein center > AGR2(Gene name) > Human
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  • AGR2 (Gene name),
  • Anterior gradient protein 2 homolog (Protein name ),  AGR2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AGR2(UNQ515/PRO1030;AG2);
    Protein name:
    Anterior gradient protein 2 homolog(AG-2;hAG-2);
    Alternative:
    Secreted cement gland protein XAG-2 homolog;HPC8;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked.
    Function:
    Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.
    Subcellular Location:
    Secreted Endoplasmic reticulum
    Protein Attributes:
    Sequence length:
    175
    Sequence:
    50:
    MEKIPVSAFL | LLVALSYTLA | RDTTVKPGAK | KDTKDSRPKL | PQTLSRGWGD | 
    100:
    QLIWTQTYEE | ALYKSKTSNK | PLMIIHHLDE | CPHSQALKKV | FAENKEIQKL | 
    150:
    AEQFVLLNLV | YETTDKHLSP | DGQYVPRIMF | VDPSLTVRAD | ITGRYSNRLY | 
    175:
    AYEPADTALL | LDNMKKALKL | LKTEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human AG-2
    ELISA Kit for Human AG-2
    CLIA Kit for Human AG-2
    CLIA Kit for Human AG-2
    Polyclonal Antibody for Human AG-2
    Polyclonal Antibody for Human AG-2
    Monoclonal Antibody for Human AG-2
    Monoclonal Antibody for Human AG-2
    Protein for Human AG-2
    Protein for Human AG-2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines."
      Thompson D.A. , Weigel R.J.
      Biochem. Biophys. Res. Commun.251:111-116(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Mammary gland.
    2. 2.
      "Identification of human homolog of XAG-2 over-expressed in tumors."
      Zhang J.S. , Smith D.I.
      Submitted (1998-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Prostatic carcinoma.
    3. 3.
      "Cloning and expression of a novel human cDNA homology to murine GOB-4 mRNA."
      Fan Y.X. , Yu L. , Zhang X.N. , Wan W.C. , Wang X.K. , Zhao S.Y.
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
    8. 8.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-35
    9. 9.
      "hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan."
      Fletcher G.C. , Patel S. , Tyson K. , Adam P.J. , Schenker M. , Loader J.A. , Daviet L. , Legrain P. , Parekh R. , Harris A.L. , Terrett J.A.
      Br. J. Cancer88:579-585(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYPD3 AND DAG1
    10. 10.
      "AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer."
      Zhang J.-S. , Gong A. , Cheville J.C. , Smith D.I. , Young C.Y.F.
      Genes Chromosomes Cancer43:249-259(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    11. 11.
      "The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformation."
      Wang Z. , Hao Y. , Lowe A.W.
      Cancer Res.68:492-497(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "The protein disulfide isomerase AGR2 is essential for production of intestinal mucus."
      Park S.-W. , Zhen G. , Verhaeghe C. , Nakagami Y. , Nguyenvu L.T. , Barczak A.J. , Killeen N. , Erle D.J.
      Proc. Natl. Acad. Sci. U.S.A.106:6950-6955(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MUC2;MUTAGENESIS OF CYS-81
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