AHRR ELISA Kit for Human(Homo sapiens) | EIAab.comAHRR ELISA Kit for Human(Homo sapiens) | EIAab.com

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AHRR (Gene name),

Aryl hydrocarbon receptor repressor (Protein name ), AHRR_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

AHRR(BHLHE77;KIAA1234);

Protein name:

Aryl hydrocarbon receptor repressor(AhR repressor;AhRR);

Alternative:

Class E basic helix-loop-helix protein 77(bHLHe77);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ARNT, ANKRA2, HDAC4 and HDAC5.

Function:

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.

Subcellular Location:

Cytoplasm Nucleus Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.

Protein Attributes:

Sequence length:

701

Sequence:

50:

MPRTMIPPGE | CTYAGRKRRR | PLQKQRPAVG | AEKSNPSKRH | RDRLNAELDH |

100:

LASLLPFPPD | IISKLDKLSV | LRLSVSYLRV | KSFFQVVQEQ | SSRQPAAGAP |

150:

SPGDSCPLAG | SAVLEGRLLL | ESLNGFALVV | SAEGTIFYAS | ATIVDYLGFH |

200:

QTDVMHQNIY | DYIHVDDRQD | FCRQLHWAMD | PPQVVFGQPP | PLETGDDAIL |

250:

GRLLRAQEWG | TGTPTEYSAF | LTRCFICRVR | CLLDSTSGFL | TMQFQGKLKF |

300:

LFGQKKKAPS | GAMLPPRLSL | FCIAAPVLLP | SAAEMKMRSA | LLRAKPRADT |

350:

AATADAKVKA | TTSLCESELH | GKPNYSAGRS | SRESGVLVLR | EQTDAGRWAQ |

400:

VPARAPCLCL | RGGPDLVLDP | KGGSGDREEE | QHRMLSRASG | VTGRRETPGP |

450:

TKPLPWTAGK | HSEDGARPRL | QPSKNDPPSL | RPMPRGSCLP | CPCVQGTFRN |

500:

SPISHPPSPS | PSAYSSRTSR | PMRDVGEDQV | HPPLCHFPQR | SLQHQLPQPG |

550:

AQRFATRGYP | MEDMKLQGVP | MPPGDLCGPT | LLLDVSIKME | KDSGCEGAAD |

600:

GCVPSQVWLG | ASDRSHPATF | PTRMHLKTEP | DSRQQVYISH | LGHGVRGAQP |

650:

HGRATAGRSR | ELTPFHPAHC | ACLEPTDGLP | QSEPPHQLCA | RGRGEQSCTC |

700:

RAAEAAPVVK | REPLDSPQWA | THSQGMVPGM | LPKSALATLV | PPQASGCTFL |

701:

P

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

SMR:

KEGG:

MIM:

String:

Pfam:

Uniprot:

FOR

ELISA Kit for Human AhR repressor

ELISA Kit for Human AhR repressor

ELISA Kit for Human AhR repressor

CLIA Kit for Human AhR repressor

CLIA Kit for Human AhR repressor

CLIA Kit for Human AhR repressor

Polyclonal Antibody for Human AhR repressor

Polyclonal Antibody for Human AhR repressor

Polyclonal Antibody for Human AhR repressor

Monoclonal Antibody for Human AhR repressor

Monoclonal Antibody for Human AhR repressor

Monoclonal Antibody for Human AhR repressor

Protein for Human AhR repressor

Protein for Human AhR repressor

Protein for Human AhR repressor

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Characterization of the aryl hydrocarbon receptor repressor gene and association of its Pro185Ala polymorphism with micropenis."
Fujita H. , Kosaki R. , Yoshihashi H. , Ogata T. , Tomita M. , Hasegawa T. , Takahashi T. , Matsuo N. , Kosaki K.
Teratology65:10-18(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3);TISSUE SPECIFICITY;VARIANT PRO-114
2.

"Identification and functional analysis of a human AHR repressor."
Karchner S.I. , Evans B. , Jenny M.J. , Hahn M.E.
Submitted (2007-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-189
3.

"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Ishikawa K. , Kikuno R. , Hirosawa M. , Nomura N. , Ohara O.
DNA Res.6:337-345(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT ALA-189
tissue: Brain.
4.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-189
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT ALA-189
7.

"Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells."
Yamamoto J. , Ihara K. , Nakayama H. , Hikino S. , Satoh K. , Kubo N. , Iida T. , Fujii Y. , Hara T.
Life Sci.74:1039-1049(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
8.

"Identification of intracellular localization signals and of mechanisms underlining the nucleocytoplasmic shuttling of human aryl hydrocarbon receptor repressor."
Kanno Y. , Miyama Y. , Takane Y. , Nakahama T. , Inouye Y.
Biochem. Biophys. Res. Commun.364:1026-1031(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
9.

"Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines."
Haarmann-Stemmann T. , Bothe H. , Kohli A. , Sydlik U. , Abel J. , Fritsche E.
Drug Metab. Dispos.35:2262-2269(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers."
Zudaire E. , Cuesta N. , Murty V. , Woodson K. , Adams L. , Gonzalez N. , Martinez A. , Narayan G. , Kirsch I. , Franklin W. , Hirsch F. , Birrer M. , Cuttitta F.
J. Clin. Invest.118:640-650(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION
11.

"Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins."
Watanabe M. , Sueoka K. , Sasagawa I. , Nakabayashi A. , Yoshimura Y. , Ogata T.
Fertil. Steril.82:1067-1071(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;ASSOCIATION WITH SUSCEPTIBILITY TO MALE INFERTILITY
12.

"Analysis of the AhR, ARNT, and AhRR gene polymorphisms: genetic contribution to endometriosis susceptibility and severity."
Tsuchiya M. , Katoh T. , Motoyama H. , Sasaki H. , Tsugane S. , Ikenoue T.
Fertil. Steril.84:454-458(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;ASSOCIATION WITH SUSCEPTIBILITY TO ENDOMETRIOSIS
13.

"The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility."
Merisalu A. , Punab M. , Altmaee S. , Haller K. , Tiido T. , Peters M. , Salumets A.
Fertil. Steril.88:854-859(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;ASSOCIATION WITH SUSCEPTIBILITY TO MALE INFERTILITY

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