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Index > Protein center > AIFM2(Gene name) > Human
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  • AIFM2 (Gene name),
  • Apoptosis-inducing factor 2 (Protein name ),  AIFM2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AIFM2(AMID;PRG3);
    Protein name:
    Apoptosis-inducing factor 2;
    Alternative:
    Apoptosis-inducing factor-like mitochondrion-associated inducer of death;Apoptosis-inducing factor homologous mitochondrion-associated inducer of death;p53-responsive gene 3 protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.
    Subcellular Location:
    Cytoplasm Mitochondrion outer membrane
    Protein Attributes:
    Sequence length:
    373
    Sequence:
    50:
    MGSQVSVESG | ALHVVIVGGG | FGGIAAASQL | QALNVPFMLV | DMKDSFHHNV | 
    100:
    AALRASVETG | FAKKTFISYS | VTFKDNFRQG | LVVGIDLKNQ | MVLLQGGEAL | 
    150:
    PFSHLILATG | STGPFPGKFN | EVSSQQAAIQ | AYEDMVRQVQ | RSRFIVVVGG | 
    200:
    GSAGVEMAAE | IKTEYPEKEV | TLIHSQVALA | DKELLPSVRQ | EVKEILLRKG | 
    250:
    VQLLLSERVS | NLEELPLNEY | REYIKVQTDK | GTEVATNLVI | LCTGIKINSS | 
    300:
    AYRKAFESRL | ASSGALRVNE | HLQVEGHSNV | YAIGDCADVR | TPKMAYLAGL | 
    350:
    HANIAVANIV | NSVKQRPLQA | YKPGALTFLL | SMGRNDGVGQ | ISGFYVGRLM | 
    373:
    VRLTKSRDLF | VSTSWKTMRQ | SPP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    SMR:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Apoptosis-inducing factor 2
    ELISA Kit for Human Apoptosis-inducing factor 2
    ELISA Kit for Human Apoptosis-inducing factor 2
    CLIA Kit for Human Apoptosis-inducing factor 2
    CLIA Kit for Human Apoptosis-inducing factor 2
    CLIA Kit for Human Apoptosis-inducing factor 2
    Polyclonal Antibody for Human Apoptosis-inducing factor 2
    Polyclonal Antibody for Human Apoptosis-inducing factor 2
    Polyclonal Antibody for Human Apoptosis-inducing factor 2
    Monoclonal Antibody for Human Apoptosis-inducing factor 2
    Monoclonal Antibody for Human Apoptosis-inducing factor 2
    Monoclonal Antibody for Human Apoptosis-inducing factor 2
    Protein for Human Apoptosis-inducing factor 2
    Protein for Human Apoptosis-inducing factor 2
    Protein for Human Apoptosis-inducing factor 2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)."
      Ohiro Y. , Garkavtsev I. , Kobayashi S. , Sreekumar K.R. , Nantz R. , Higashikubo B.T. , Duffy S.L. , Higashikubo R. , Usheva A. , Gius D. , Kley N. , Horikoshi N.
      FEBS Lett.524:163-171(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION
    2. 2.
      "AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis."
      Wu M. , Xu L.-G. , Li X. , Zhai Z. , Shu H.-B.
      J. Biol. Chem.277:25617-25623(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Hippocampus.
    4. 4.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
      tissue: Lung.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 23-373 (ISOFORM 2)
      tissue: Esophageal carcinoma.
    8. 8.
      "AMID is a p53-inducible gene downregulated in tumors."
      Wu M. , Xu L.-G. , Su T. , Tian Y. , Zhai Z. , Shu H.-B.
      Oncogene23:6815-6819(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    9. 9.
      "The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity."
      Marshall K.R. , Gong M. , Wodke L. , Lamb J.H. , Jones D.J. , Farmer P.B. , Scrutton N.S. , Munro A.W.
      J. Biol. Chem.280:30735-30740(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;COFACTOR
    10. 10.
      "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."
      Suzuki T. , Moriya K. , Nagatoshi K. , Ota Y. , Ezure T. , Ando E. , Tsunasawa S. , Utsumi T.
      Proteomics10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MYRISTOYLATION AT GLY-2
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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