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Index > Protein center > Aimp2(Gene name) > Rat
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  • Aimp2 (Gene name),
  • Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Protein name ),  AIMP2_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Aimp2(Jtv1);
    Protein name:
    Aminoacyl tRNA synthase complex-interacting multifunctional protein 2;
    Alternative:
    Protein JTV-1;Multisynthase complex auxiliary component p38;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Component of the aminoacyl-tRNA synthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Binds FUBP1 (via C-terminus). Interacts in both its unphosphorylated and phosphorylated forms with p53/TP53 (via N-terminus) in the nucleus following UV irradiation. Interacts (via N-terminus) with KARS and PARK2/parkin (via first RING-type domain).
    Function:
    Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
    Subcellular Location:
    Cytoplasm cytosol Nucleus Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.
    Protein Attributes:
    Sequence length:
    320
    Sequence:
    50:
    MPMYQVKPYH | GGSAPLRVEL | PTCMYRLPNV | HSKTTSPATD | AGHVQEPSEP | 
    100:
    SLRALESRQD | DILKRLYELK | AAVDGLSKMI | HTPDADLDVT | NILQADEPTT | 
    150:
    LTTNALDLNS | VLGKDYGALK | DIVINANPAS | PPLSLLVLHR | LLCERYRVLS | 
    200:
    TVHTHSSVKN | VPENLLKCFG | EQARKQSRHE | YQLGFTLIWK | NVPKTQMKFS | 
    250:
    VQTMCPIEGE | GNIARFLFSL | FGQKHNAVHL | TLIDSWVDIA | MFQLREGSSK | 
    300:
    EKAAVFRSMN | SALGKSPWLV | GNELTVADVV | LWSVLQQTGG | SSGAAPTNVQ | 
    320:
    RWLKSCENLA | PFSTALQLLK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    E2927h
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    Packing:
    96T
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    ELISA Kit for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    E2927r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    E2927m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    E2927b
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    Packing:
    96T
    CLIA Kit for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    U2927b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    U2927m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    U2927r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    U2927h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Polyclonal Antibody for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    P2927Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    P2927Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Cat.:
    P2927Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Monoclonal Antibody for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Monoclonal Antibody for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Monoclonal Antibody for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
    Protein for Rat Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

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    Precision
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    References
    1. 1.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Thymus.
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