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Index > Protein center > AKR1A1(Gene name) > Human
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  • AKR1A1 (Gene name),
  • Alcohol dehydrogenase [NADP+] (Protein name ),  AK1A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    AKR1A1(ALDR1;ALR);
    Protein name:
    Alcohol dehydrogenase [NADP+];
    Alternative:
    Aldo-keto reductase family 1 member A1;Aldehyde reductase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    325
    Sequence:
    50:
    MAASCVLLHT | GQKMPLIGLG | TWKSEPGQVK | AAVKYALSVG | YRHIDCAAIY | 
    100:
    GNEPEIGEAL | KEDVGPGKAV | PREELFVTSK | LWNTKHHPED | VEPALRKTLA | 
    150:
    DLQLEYLDLY | LMHWPYAFER | GDNPFPKNAD | GTICYDSTHY | KETWKALEAL | 
    200:
    VAKGLVQALG | LSNFNSRQID | DILSVASVRP | AVLQVECHPY | LAQNELIAHC | 
    250:
    QARGLEVTAY | SPLGSSDRAW | RDPDEPVLLE | EPVVLALAEK | YGRSPAQILL | 
    300:
    RWQVQRKVIC | IPKSITPSRI | LQNIKVFDFT | FSPEEMKQLN | ALNKNWRYIV | 
    325:
    PMLTVDGKRV | PRDAGHPLYP | FNDPY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    SMR:
    Pfam:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    E14182b
    Price:
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    Packing:
    96T
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    ELISA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    E14182c
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    E14182p
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    MSDS:
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    96T
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    ELISA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    E14182h
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    96T
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    ELISA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    E14182m
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    E14182r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    U14182m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    U14182b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    U14182h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    U14182p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    U14182r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    U14182c
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    P14182Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    P14182Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Cat.:
    P14182Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Monoclonal Antibody for Human Alcohol dehydrogenase [NADP+]
    Protein for Human Alcohol dehydrogenase [NADP+]
    Protein for Human Alcohol dehydrogenase [NADP+]
    Protein for Human Alcohol dehydrogenase [NADP+]
    Protein for Human Alcohol dehydrogenase [NADP+]
    Protein for Human Alcohol dehydrogenase [NADP+]
    Protein for Human Alcohol dehydrogenase [NADP+]

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    Linearity
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    References
    1. 1.
      "The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases."
      Bohren K.M. , Bullock B. , Wermuth B. , Gabbay K.H.
      J. Biol. Chem.264:9547-9551(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
      tissue: Liver.
    2. 2.
      "The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32."
      Fujii J. , Hamaoka R. , Matsumoto A. , Fujii T. , Yamaguchi Y. , Egashira M. , Miyoshi O. , Niikawa N. , Taniguchi N.
      Cytogenet. Cell Genet.84:230-232(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Characterization of the human aldehyde reductase gene and promoter."
      Barski O.A. , Gabbay K.H. , Bohren K.M.
      Genomics60:188-198(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
      tissue: Kidney.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-325
      tissue: Liver.
    11. 11.
      "Mechanism of human aldehyde reductase: characterization of the active site pocket."
      Barski O.A. , Gabbay K.H. , Grimshaw C.E. , Bohren K.M.
      Biochemistry34:11264-11275(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-50; LYS-80; HIS-113; ILE-299 AND VAL-300
    12. 12.
      "Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members."
      O'Connor T. , Ireland L.S. , Harrison D.J. , Hayes J.D.
      Biochem. J.343:487-504(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    13. 13.
      "Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1)."
      Palackal N.T. , Burczynski M.E. , Harvey R.G. , Penning T.M.
      Chem. Biol. Interact.130:815-824(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    14. 14.
      "Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin."
      Bains O.S. , Takahashi R.H. , Pfeifer T.A. , Grigliatti T.A. , Reid R.E. , Riggs K.W.
      Drug Metab. Dispos.36:904-910(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANTS SER-52 AND ASP-55
    15. 15.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "Structures of human and porcine aldehyde reductase: an enzyme implicated in diabetic complications."
      El-Kabbani O. , Green N.C. , Lin G. , Carson M. , Narayana S.V.L. , Moore K.M. , Flynn T.G. , DeLucas L.J.
      Acta Crystallogr. D50:859-868(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS)
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