Akt1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAkt1 ELISA Kit for Rat(Rattus norvegicus)

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Akt1 (Gene name),

RAC-alpha serine/threonine-protein kinase (Protein name ), AKT1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Akt1;

Protein name:

RAC-alpha serine/threonine-protein kinase;

Alternative:

Protein kinase B alpha(PKB alpha);Protein kinase B(PKB);RAC-PK-alpha;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with AKTIP. Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B. Interacts with RARA; the interaction phosphorylates RARA and represses its transactivation activity. Interacts with TRAF6. Interacts with GRB10; the interaction leads to GRB10 phosphorylation thus promoting YWHAE binding. Interacts (via the C-terminus) with CCDC88A (via its C-terminus) and THEM4 (via its C-terminus) (By similarity). Interacts with MAP3K5 and TNK2 (By similarity). Interacts with CLK2 and PPP2R5B (By similarity). Interacts with STK3/MST2 and STK4/MST1.

Function:

AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.

Subcellular Location:

Cytoplasm Nucleus Cell membrane Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A (By similarity). Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus.

Protein Attributes:

Sequence length:

480

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

480:

PPDQDDSMEC | VDSERRPHFP | QFSYSASGTA |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P47196

Pfam:

PF00169

UniGene:

Rn.11422

KEGG:

rno:24185

STRING:

10116.ENSRNOP00000038369

SMR:

P47196

Uniprot:

P47196

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ELISA Kit for Rat RAC-alpha serine/threonine-protein kinase

Cat.:

E0382r

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96T

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ELISA Kit for Rat RAC-alpha serine/threonine-protein kinase

Cat.:

E0382h

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96T

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ELISA Kit for Rat RAC-alpha serine/threonine-protein kinase

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E0382m

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ELISA Kit for Rat RAC-alpha serine/threonine-protein kinase

Cat.:

E0382b

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96T

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CLIA Kit for Rat RAC-alpha serine/threonine-protein kinase

Cat.:

U0382b

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Packing:

96T

CLIA Kit for Rat RAC-alpha serine/threonine-protein kinase

Cat.:

U0382m

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Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Rat RAC-alpha serine/threonine-protein kinase

Cat.:

U0382h

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96T

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CLIA Kit for Rat RAC-alpha serine/threonine-protein kinase

Cat.:

U0382r

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96T

Polyclonal Antibody for Rat RAC-alpha serine/threonine-protein kinase

Cat.:

P0382Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat RAC-alpha serine/threonine-protein kinase

Cat.:

P0382Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat RAC-alpha serine/threonine-protein kinase

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P0382Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat RAC-alpha serine/threonine-protein kinase

Monoclonal Antibody for Rat RAC-alpha serine/threonine-protein kinase

Protein for Rat RAC-alpha serine/threonine-protein kinase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta."
Konishi H. , Shinomura T. , Kuroda S.I. , Ono Y. , Kikkawa U.
Biochem. Biophys. Res. Commun.205:817-825(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Testis.
2.

"Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport."
Kitamura T. , Ogawa W. , Sakaue H. , Hino Y. , Kuroda S. , Takata M. , Matsumoto M. , Maeda T. , Konishi H. , Kikkawa U. , Kasuga M.
Mol. Cell. Biol.18:3708-3717(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LYS-179; THR-308 AND SER-473
3.

"Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)."
Takata M. , Ogawa W. , Kitamura T. , Hino Y. , Kuroda S. , Kotani K. , Klip A. , Gingras A.-C. , Sonenberg N. , Kasuga M.
J. Biol. Chem.274:20611-20618(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-308 AND SER-473;MUTAGENESIS OF LYS-179; THR-308 AND SER-473
4.

"The protein kinase B/Akt signalling pathway in human malignancy."
Nicholson K.M. , Anderson N.G.
Cell. Signal.14:381-395(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
5.

"The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes."
Berwick D.C. , Hers I. , Heesom K.J. , Moule S.K. , Tavare J.M.
J. Biol. Chem.277:33895-33900(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF ACLY
6.

"Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles."
Berwick D.C. , Dell G.C. , Welsh G.I. , Heesom K.J. , Hers I. , Fletcher L.M. , Cooke F.T. , Tavare J.M.
J. Cell Sci.117:5985-5993(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PIKFYVE
7.

"Ebp1 isoforms distinctively regulate cell survival and differentiation."
Liu Z. , Ahn J.Y. , Liu X. , Ye K.
Proc. Natl. Acad. Sci. U.S.A.103:10917-10922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PA2G4
8.

"Akt signalling in health and disease."
Hers I. , Vincent E.E. , Tavare J.M.
Cell. Signal.23:1515-1527(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
9.

"Akt1 and Akt2: differentiating the aktion."
Heron-Milhavet L. , Khouya N. , Fernandez A. , Lamb N.J.
Histol. Histopathol.26:651-662(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION

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