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Index > Protein center > ALS2CL(Gene name) > Human
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  • ALS2CL (Gene name),
  • ALS2 C-terminal-like protein (Protein name ),  AL2CL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ALS2CL;
    Protein name:
    ALS2 C-terminal-like protein;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Forms a heteromeric complex with ALS2 (By similarity). Interacts with ALS2 and RAB5A.
    Function:
    Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.
    Subcellular Location:
    Cytoplasm Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
    Protein Attributes:
    Sequence length:
    953
    Sequence:
    50:
    MCNPEEAALL | RLEEVFSATL | AHVNSLVLQP | LLPAAPDPSD | PWGRECLRLL | 
    100:
    QQLHKSSQQL | WEVTEESLHS | LQERLRYPDS | TGLESLLLLR | GADRVLQAHI | 
    150:
    EYIESYTSCM | VVQAFQKAAK | RRSEYWRGQR | KALRQLLSGV | SSEGSVGASL | 
    200:
    GQALHQPLAH | HVQQYVLLLL | SLGDTIGEHH | PTRELVVNAV | TLFGNLQSFM | 
    250:
    KQELDQAVAT | QALWHTLRGR | LRDVLCTPAH | RLLQDSQDVP | VTVAPLRAER | 
    300:
    VLLFDDALVL | LQGHNVHTFD | LKLVWVDPGQ | DGCTFHLLTP | EEEFSFCAKD | 
    350:
    SQGQAVWQWK | VTWAVHQALH | GKKDFPVLGA | GLEPSQPPDC | RCAEYTFQAE | 
    400:
    GRLCQATYEG | EWCRGRPHGK | GTLKWPDGRN | HVGNFCQGLE | HGFGIRLLPQ | 
    450:
    ASEDKFDCYK | CHWREGSMCG | YGICEYSTDE | VYKGYFQEGL | RHGFGVLESG | 
    500:
    PQAPQPFRYT | GHWERGQRSG | YGIEEDGDRG | ERYIGMWQAG | QRHGPGVMVT | 
    550:
    QAGVCYQGTF | QADKTVGPGI | LLSEDDSLYE | GTFTRDLTLM | GKGKVTFPNG | 
    600:
    FTLEGSFGSG | AGRGLHTQGV | LDTAALPPDP | SSTCKRQLGV | GAFPVESRWQ | 
    650:
    GVYSPFRDFV | CAGCPRDLQE | ALLGFDVQSS | RELRRSQDYL | SCERTHPEDS | 
    700:
    VGSMEDILEE | LLQHREPKAL | QLYLRKALSN | SLHPLGKLLR | TLMLTFQATY | 
    750:
    AGVGANKHLQ | ELAQEEVKQH | AQELWAAYRG | LLRVALERKG | QALEEDEDTE | 
    800:
    TRDLQVHGLV | LPLMLPSFYS | ELFTLYLLLH | EREDSFYSQG | IANLSLFPDT | 
    850:
    QLLEFLDVQK | HLWPLKDLTL | TSNQRYSLVR | DKCFLSATEC | LQKIMTTVDP | 
    900:
    REKLEVLERT | YGEIEGTVSR | VLGREYKLPM | DDLLPLLIYV | VSRARIQHLG | 
    950:
    AEIHLIRDMM | DPNHTGGLYD | FLLTALESCY | EHIQKEDMRL | HRLPGHWHSR | 
    953:
    ELW
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    MIM:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human ALS2 C-terminal-like protein
    ELISA Kit for Human ALS2 C-terminal-like protein
    ELISA Kit for Human ALS2 C-terminal-like protein
    CLIA Kit for Human ALS2 C-terminal-like protein
    CLIA Kit for Human ALS2 C-terminal-like protein
    CLIA Kit for Human ALS2 C-terminal-like protein
    Polyclonal Antibody for Human ALS2 C-terminal-like protein
    Polyclonal Antibody for Human ALS2 C-terminal-like protein
    Polyclonal Antibody for Human ALS2 C-terminal-like protein
    Monoclonal Antibody for Human ALS2 C-terminal-like protein
    Monoclonal Antibody for Human ALS2 C-terminal-like protein
    Monoclonal Antibody for Human ALS2 C-terminal-like protein
    Protein for Human ALS2 C-terminal-like protein
    Protein for Human ALS2 C-terminal-like protein
    Protein for Human ALS2 C-terminal-like protein

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics."
      Hadano S. , Otomo A. , Suzuki-Utsunomiya K. , Kunita R. , Yanagisawa Y. , Showguchi-Miyata J. , Mizumura H. , Ikeda J.-E.
      FEBS Lett.575:64-70(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH RAB5A;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Liver.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3; 4 AND 6)
      tissue: Placenta.
      tissue: Tongue.
      tissue: Trachea.
      tissue: Uterus.
    3. 3.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 293-953 (ISOFORM 1)
      tissue: Prostate.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-392 (ISOFORM 1);VARIANT GLN-45
      tissue: Cervix.
    7. 7.
      "Purification and functional analyses of ALS2 and its homologue."
      Hadano S. , Ikeda J.-E.
      Methods Enzymol.403:310-321(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics."
      Suzuki-Utsunomiya K. , Hadano S. , Otomo A. , Kunita R. , Mizumura H. , Osuga H. , Ikeda J.-E.
      Biochem. Biophys. Res. Commun.354:491-497(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;HOMODIMERIZATION;INTERACTION WITH ALS2;SUBCELLULAR LOCATION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-280 AND PHE-576
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