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Index > Protein center > PAM(Gene name) > Human
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  • PAM (Gene name),
  • Peptidyl-glycine alpha-amidating monooxygenase (Protein name ),  AMD_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PAM;
    Protein name:
    Peptidyl-glycine alpha-amidating monooxygenase(PAM);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. Interacts with RASSF9.
    Function:
    Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
    Subcellular Location:
    Isoform 4 Secreted Secreted from secretory granules.
    Protein Attributes:
    Sequence length:
    973
    Sequence:
    50:
    MAGRVPSLLV | LLVFPSSCLA | FRSPLSVFKR | FKETTRPFSN | ECLGTTRPVV | 
    100:
    PIDSSDFALD | IRMPGVTPKQ | SDTYFCMSMR | IPVDEEAFVI | DFKPRASMDT | 
    150:
    VHHMLLFGCN | MPSSTGSYWF | CDEGTCTDKA | NILYAWARNA | PPTRLPKGVG | 
    200:
    FRVGGETGSK | YFVLQVHYGD | ISAFRDNNKD | CSGVSLHLTR | LPQPLIAGMY | 
    250:
    LMMSVDTVIP | AGEKVVNSDI | SCHYKNYPMH | VFAYRVHTHH | LGKVVSGYRV | 
    300:
    RNGQWTLIGR | QSPQLPQAFY | PVGHPVDVSF | GDLLAARCVF | TGEGRTEATH | 
    350:
    IGGTSSDEMC | NLYIMYYMEA | KHAVSFMTCT | QNVAPDMFRT | IPPEANIPIP | 
    400:
    VKSDMVMMHE | HHKETEYKDK | IPLLQQPKRE | EEEVLDQGDF | YSLLSKLLGE | 
    450:
    REDVVHVHKY | NPTEKAESES | DLVAEIANVV | QKKDLGRSDA | REGAEHERGN | 
    500:
    AILVRDRIHK | FHRLVSTLRP | PESRVFSLQQ | PPPGEGTWEP | EHTGDFHMEE | 
    550:
    ALDWPGVYLL | PGQVSGVALD | PKNNLVIFHR | GDHVWDGNSF | DSKFVYQQIG | 
    600:
    LGPIEEDTIL | VIDPNNAAVL | QSSGKNLFYL | PHGLSIDKDG | NYWVTDVALH | 
    650:
    QVFKLDPNNK | EGPVLILGRS | MQPGSDQNHF | CQPTDVAVDP | GTGAIYVSDG | 
    700:
    YCNSRIVQFS | PSGKFITQWG | EESSGSSPLP | GQFTVPHSLA | LVPLLGQLCV | 
    750:
    ADRENGRIQC | FKTDTKEFVR | EIKHSSFGRN | VFAISYIPGL | LFAVNGKPHF | 
    800:
    GDQEPVQGFV | MNFSNGEIID | IFKPVRKHFD | MPHDIVASED | GTVYIGDAHT | 
    850:
    NTVWKFTLTE | KLEHRSVKKA | GIEVQEIKEA | EAVVETKMEN | KPTSSELQKM | 
    900:
    QEKQKLIKEP | GSGVPVVLIT | TLLVIPVVVL | LAIAIFIRWK | KSRAFGDSEH | 
    950:
    KLETSSGRVL | GRFRGKGSGG | LNLGNFFASR | KGYSRKGFDR | LSTEGSDQEK | 
    973:
    EDDGSESEEE | YSAPLPALAP | SSS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    KEGG:
    String:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human PAM
    ELISA Kit for Human PAM
    ELISA Kit for Human PAM
    ELISA Kit for Human PAM
    CLIA Kit for Human PAM
    CLIA Kit for Human PAM
    CLIA Kit for Human PAM
    CLIA Kit for Human PAM
    Polyclonal Antibody for Human PAM
    Polyclonal Antibody for Human PAM
    Polyclonal Antibody for Human PAM
    Polyclonal Antibody for Human PAM
    Monoclonal Antibody for Human PAM
    Monoclonal Antibody for Human PAM
    Monoclonal Antibody for Human PAM
    Monoclonal Antibody for Human PAM
    Protein for Human PAM
    Protein for Human PAM
    Protein for Human PAM
    Protein for Human PAM

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells."
      Glauder J. , Ragg H. , Rauch J. , Engels J.W.
      Biochem. Biophys. Res. Commun.169:551-558(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
      tissue: Thyroid carcinoma.
    2. 2.
      "Isolation and functional expression of human pancreatic peptidylglycine alpha-amidating monooxygenase."
      Tateishi K. , Arakawa F. , Misumi Y. , Treston A.M. , Vos M. , Matsuoka Y.
      Biochem. Biophys. Res. Commun.205:282-290(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3)
    3. 3.
      "Expression and characterization of human bifunctional peptidylglycine alpha-amidating monooxygenase."
      Satani M. , Takahashi K. , Sakamoto H. , Harada S. , Kaida Y. , Noguchi M.
      Protein Expr. Purif.28:293-302(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);COFACTOR;ENZYME REGULATION
      tissue: Heart.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Thalamus.
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Lung.
    8. 9.
      "The alpha-amidating monooxygenase gene of human kidney."
      Chung B.H. , Oh G.H. , Choi E.S.
      Submitted (1997-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 29-973 (ISOFORM 4)
      tissue: Kidney.
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 707-973 (ISOFORM 6)
      tissue: Brain.
    10. 11.
      "Alternative splicing governs sulfation of tyrosine or oligosaccharide on peptidylglycine alpha-amidating monooxygenase."
      Yun H.Y. , Keutmann H.T. , Eipper B.A.
      J. Biol. Chem.269:10946-10955(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION AT TYR-961
    11. 12.
      "The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase."
      Caldwell B.D. , Darlington D.N. , Penzes P. , Johnson R.C. , Eipper B.A. , Mains R.E.
      J. Biol. Chem.274:34646-34656(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-943 AND SER-946 BY UHMK1
    12. 13.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-946;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-929;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 15.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-942 AND SER-946;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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