Protein name:
Peptidyl-glycine alpha-amidating monooxygenase (PAM) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Monomer. Interacts with RASSF9.
Function:
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Subcellular Location:
Isoform 4
Secreted
Secreted from secretory granules.
Protein Attributes:
50:
MAGRVPSLLV | LLVFPSSCLA | FRSPLSVFKR | FKETTRPFSN | ECLGTTRPVV |
100:
PIDSSDFALD | IRMPGVTPKQ | SDTYFCMSMR | IPVDEEAFVI | DFKPRASMDT |
150:
VHHMLLFGCN | MPSSTGSYWF | CDEGTCTDKA | NILYAWARNA | PPTRLPKGVG |
200:
FRVGGETGSK | YFVLQVHYGD | ISAFRDNNKD | CSGVSLHLTR | LPQPLIAGMY |
250:
LMMSVDTVIP | AGEKVVNSDI | SCHYKNYPMH | VFAYRVHTHH | LGKVVSGYRV |
300:
RNGQWTLIGR | QSPQLPQAFY | PVGHPVDVSF | GDLLAARCVF | TGEGRTEATH |
350:
IGGTSSDEMC | NLYIMYYMEA | KHAVSFMTCT | QNVAPDMFRT | IPPEANIPIP |
400:
VKSDMVMMHE | HHKETEYKDK | IPLLQQPKRE | EEEVLDQGDF | YSLLSKLLGE |
450:
REDVVHVHKY | NPTEKAESES | DLVAEIANVV | QKKDLGRSDA | REGAEHERGN |
500:
AILVRDRIHK | FHRLVSTLRP | PESRVFSLQQ | PPPGEGTWEP | EHTGDFHMEE |
550:
ALDWPGVYLL | PGQVSGVALD | PKNNLVIFHR | GDHVWDGNSF | DSKFVYQQIG |
600:
LGPIEEDTIL | VIDPNNAAVL | QSSGKNLFYL | PHGLSIDKDG | NYWVTDVALH |
650:
QVFKLDPNNK | EGPVLILGRS | MQPGSDQNHF | CQPTDVAVDP | GTGAIYVSDG |
700:
YCNSRIVQFS | PSGKFITQWG | EESSGSSPLP | GQFTVPHSLA | LVPLLGQLCV |
750:
ADRENGRIQC | FKTDTKEFVR | EIKHSSFGRN | VFAISYIPGL | LFAVNGKPHF |
800:
GDQEPVQGFV | MNFSNGEIID | IFKPVRKHFD | MPHDIVASED | GTVYIGDAHT |
850:
NTVWKFTLTE | KLEHRSVKKA | GIEVQEIKEA | EAVVETKMEN | KPTSSELQKM |
900:
QEKQKLIKEP | GSGVPVVLIT | TLLVIPVVVL | LAIAIFIRWK | KSRAFGDSEH |
950:
KLETSSGRVL | GRFRGKGSGG | LNLGNFFASR | KGYSRKGFDR | LSTEGSDQEK |
973:
EDDGSESEEE | YSAPLPALAP | SSS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Mouse
Human
Polyclonal Antibody for Human PAM
Polyclonal Antibody for Human PAM
Polyclonal Antibody for Human PAM
Polyclonal Antibody for Human PAM
Monoclonal Antibody for Human PAM
Monoclonal Antibody for Human PAM
Monoclonal Antibody for Human PAM
Monoclonal Antibody for Human PAM
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
tissue :
Thyroid carcinoma .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);COFACTOR;ENZYME REGULATION
tissue :
Heart .
4.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Thalamus .
5.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
,
Chen X.
,
Rolfs A.
,
Halleck A.
,
Hines L.
,
Eisenstein S.
,
Koundinya M.
,
Raphael J.
,
Moreira D.
,
Kelley T.
,
LaBaer J.
,
Lin Y.
,
Phelan M.
,
Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
6.
"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J.
,
Martin J.
,
Terry A.
,
Couronne O.
,
Grimwood J.
,
Lowry S.
,
Gordon L.A.
,
Scott D.
,
Xie G.
,
Huang W.
,
Hellsten U.
,
Tran-Gyamfi M.
,
She X.
,
Prabhakar S.
,
Aerts A.
,
Altherr M.
,
Bajorek E.
,
Black S.
,
Branscomb E.
,
Caoile C.
,
Challacombe J.F.
,
Chan Y.M.
,
Denys M.
,
Detter J.C.
,
Escobar J.
,
Flowers D.
,
Fotopulos D.
,
Glavina T.
,
Gomez M.
,
Gonzales E.
,
Goodstein D.
,
Grigoriev I.
,
Groza M.
,
Hammon N.
,
Hawkins T.
,
Haydu L.
,
Israni S.
,
Jett J.
,
Kadner K.
,
Kimball H.
,
Kobayashi A.
,
Lopez F.
,
Lou Y.
,
Martinez D.
,
Medina C.
,
Morgan J.
,
Nandkeshwar R.
,
Noonan J.P.
,
Pitluck S.
,
Pollard M.
,
Predki P.
,
Priest J.
,
Ramirez L.
,
Retterer J.
,
Rodriguez A.
,
Rogers S.
,
Salamov A.
,
Salazar A.
,
Thayer N.
,
Tice H.
,
Tsai M.
,
Ustaszewska A.
,
Vo N.
,
Wheeler J.
,
Wu K.
,
Yang J.
,
Dickson M.
,
Cheng J.-F.
,
Eichler E.E.
,
Olsen A.
,
Pennacchio L.A.
,
Rokhsar D.S.
,
Richardson P.
,
Lucas S.M.
,
Myers R.M.
,
Rubin E.M.
more...
Nature431:268-274(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Lung .
9.
"The alpha-amidating monooxygenase gene of human kidney."
Chung B.H.
,
Oh G.H.
,
Choi E.S.
Submitted (1997-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 29-973 (ISOFORM 4)
tissue :
Kidney .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 707-973 (ISOFORM 6)
tissue :
Brain .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SULFATION AT TYR-961
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-943 AND SER-946 BY UHMK1
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-946;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-929;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-942 AND SER-946;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]