Protein name:
Peptidyl-glycine alpha-amidating monooxygenase (PAM) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer. Interacts with RASSF9.
Function:
Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.
Subcellular Location:
Cytoplasmic vesicle
secretory vesicle membrane
Single-pass membrane protein
Secretory granules.
Protein Attributes:
50:
MAGRARSRLL | LLLGLLALQS | SCLAFRSPLS | VFKRFKETTR | SFSNECLGTT |
100:
RPITPIDSSD | FTLDIRMPGV | TPKESDTYFC | MSMRLPVDEE | AFVIDFKPRA |
150:
SMDTVHHMLL | FGCNMPSSTG | SYWFCDEGTC | TDKANILYAW | ARNAPPTRLP |
200:
KGVGFRVGGE | TGSKYFVLQV | HYGDISAFRD | NHKDCSGVSL | HLTRVPQPLI |
250:
AGMYLMMSVN | TVIPPGEKVV | NSDISCHYKM | YPMHVFAYRV | HTHHLGKVVS |
300:
GYRVRNGQWT | LIGRQSPQLP | QAFYPVEHPV | DVAFGDILAA | RCVFTGEGRT |
350:
EATHIGGTSS | DEMCNLYIMY | YMEAKHAVSF | MTCTQNVAPD | MFRTIPEEAN |
400:
IPIPVKSDMV | MIHGHHKETE | NKEKSALIQQ | PKQGEEEAFE | QGDFYSLLSK |
450:
LLGEREDVVH | VHKYNPTEKT | ESGSDLVAEI | ANVVQKKDLG | RSDAREGAEH |
500:
EEGGNAILVR | DRIHKFHRLE | STLRPAESRA | LSFQQPGEGP | WEPELAGDFH |
550:
VEEALEWPGV | YLLPGQVSGV | ALDSKNNLVI | FHRGDHVWDG | NSFDSKFVYQ |
600:
QRGLGPIEED | TILVIDPNKA | EILQSSGKNL | FYLPHGLSID | TDGNYWVTDV |
650:
ALHQVFKLEP | RSKEGPLLVL | GRSMQPGSDQ | NHFCQPTDVA | VEPSTGAVFV |
700:
SDGYCNSRIV | QFSPSGKFIT | QWGEESSGSS | PKPGQFSVPH | SLALVPHLNQ |
750:
LCVADRENGR | IQCFKTDTKE | FVREIKHASF | GRNVFAISYI | PGFLFAVNGK |
800:
PYFGDQEPVQ | GFVMNFSSGE | IIDVFKPVRK | HFDMPHDIVA | SEDGTVYIGD |
850:
AHTNTVWKFT | LTESRLEVEH | RSVKKAGIEV | PEIKEAEAVV | EPKVKNKPTS |
900:
SELQKMQEKK | KLIKDPGSGV | PVVLITTLLV | IPVVVLLAIA | MFIRWKKSRA |
950:
FGDHDRKLES | SSGRVLGRLR | GKGSSGLNLG | NFFASRKGYS | RKGFDRVSTE |
979:
GSDQEKDEDD | GSESEEEYSA | PLPTPAPSS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Mouse
Human
Polyclonal Antibody for Mouse PAM
Polyclonal Antibody for Mouse PAM
Polyclonal Antibody for Mouse PAM
Polyclonal Antibody for Mouse PAM
Monoclonal Antibody for Mouse PAM
Monoclonal Antibody for Mouse PAM
Monoclonal Antibody for Mouse PAM
Monoclonal Antibody for Mouse PAM
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
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Goodstadt L.
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Meric P.
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Maglott D.
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Graves T.
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Zhou S.
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Teague B.
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Potamousis K.
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Churas C.
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Place M.
,
Herschleb J.
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Runnheim R.
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Forrest D.
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Amos-Landgraf J.
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Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .