Gene name:
AMER2 (FAM123A) ;
Protein name:
APC membrane recruitment protein 2 (Amer2) ;
Alternative:
Protein FAM123A ;
Organism:
Chicken (Gallus gallus).
General Annotation
Function:
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Protein Attributes:
50:
MDSHCDCAEP | PAAEQPSGKI | NKTAFKLFKR | RKSGGTMPSI | FGVRSKGGEG |
100:
KGASKTGMVR | SRTHDGLADA | VLESGKKEDA | GGGEAQGKDA | PSRAAGGLGG |
150:
SASSSVAKSH | SFFSLLRKNG | RPENGKAAEN | AEQRAGGRQK | KGLKGIFSSM |
200:
RWHRKDKIGK | EERGEASEIP | SGLIMPGSLT | ASLECIKEET | PKPLSETPNG |
250:
AGDTGVESQQ | EKRGGDACVS | AEEPQAGGGE | SRDSKTPPGE | DPAAAARRLE |
300:
ELCGERPDPG | AGEVGTAKDA | AITGDIPITT | IPPVEPHCDS | GQETAAAPDP |
350:
SSVDPPSEQS | IDRICLMFAD | VTSLKSFDSL | TGCGDIIADQ | EEDVGGGSGG |
400:
CEKSTPGAGK | LGAPKKHPTM | VAYQGGGEEM | ASPDQVDDTY | LQEFWDMLSQ |
450:
TEETETGGGG | GGGGGTKTPE | GLKENRGTEG | AQNRVAVKRG | GLNQIPIHLN |
500:
NKEEQKGREK | EQHEGVPNSD | EGYWDSTTPG | PEEDSTTSIQ | KETLPRDSYS |
550:
GDALYDLYAE | PDENPPGGPP | EEEVTCMPRS | KPVSPITTTC | SLKTPSSTVK |
600:
DSKIPISIKH | LASHPASHGT | DTSNSHHVAH | HHLAKSEMHR | TKIPVSKVLV |
624:
RRVSNRGLAG | TTVKAATHQD | SAKK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Chicken
Human
ELISA Kit for Chicken Amer2
ELISA Kit for Chicken Amer2
ELISA Kit for Chicken Amer2
CLIA Kit for Chicken Amer2
CLIA Kit for Chicken Amer2
CLIA Kit for Chicken Amer2
Polyclonal Antibody for Chicken Amer2
Polyclonal Antibody for Chicken Amer2
Polyclonal Antibody for Chicken Amer2
Monoclonal Antibody for Chicken Amer2
Monoclonal Antibody for Chicken Amer2
Monoclonal Antibody for Chicken Amer2
Protein for Chicken Amer2
Protein for Chicken Amer2
Protein for Chicken Amer2
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Nature432:695-716(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Red jungle fowl .